Human Gene ADNP2 (uc002lnw.3) Description and Page Index
  Description: Homo sapiens ADNP homeobox 2 (ADNP2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr18:77,866,915-77,898,228 Size: 31,314 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr18:77,875,426-77,896,692 Size: 21,267 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr18:77,866,915-77,898,228)mRNA (may differ from genome)Protein (1131 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ADNP homeobox protein 2; AltName: Full=Zinc finger protein 508;
FUNCTION: May be involved in transcriptional regulation.
INTERACTION: P83916:CBX1; NbExp=2; IntAct=EBI-2838654, EBI-78129;
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 4 C2H2-type zinc fingers.
SIMILARITY: Contains 1 homeobox DNA-binding domain.
SEQUENCE CAUTION: Sequence=BAA74886.2; Type=Erroneous initiation; Sequence=BAB14180.1; Type=Frameshift; Positions=466;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.32 RPKM in Testis
Total median expression: 237.39 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -237.40455-0.522 Picture PostScript Text
3' UTR -401.701536-0.262 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q6IQ32
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0034599 cellular response to oxidative stress
GO:0060548 negative regulation of cell death
GO:0071300 cellular response to retinoic acid

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BC071589 - Homo sapiens ADNP homeobox 2, mRNA (cDNA clone MGC:87344 IMAGE:30333923), complete cds.
AK292566 - Homo sapiens cDNA FLJ78768 complete cds.
AB020670 - Homo sapiens KIAA0863 mRNA for KIAA0863 protein.
JD478359 - Sequence 459383 from Patent EP1572962.
AB384023 - Synthetic construct DNA, clone: pF1KSDA0863, Homo sapiens ZNF508 gene for zinc finger protein 508, complete cds, without stop codon, in Flexi system.
EU446693 - Synthetic construct Homo sapiens clone IMAGE:100070291; IMAGE:100011902; FLH258351.01L ADNP homeobox 2 (ADNP2) gene, encodes complete protein.
AK022688 - Homo sapiens cDNA FLJ12626 fis, clone NT2RM4001810, weakly similar to AGGRECAN CORE PROTEIN PRECURSOR.
AK023032 - Homo sapiens cDNA FLJ12970 fis, clone NT2RP2005859, highly similar to Homo sapiens mRNA for KIAA0863 protein.
JD348449 - Sequence 329473 from Patent EP1572962.
JD231699 - Sequence 212723 from Patent EP1572962.
JD492346 - Sequence 473370 from Patent EP1572962.
JD519903 - Sequence 500927 from Patent EP1572962.
JD186619 - Sequence 167643 from Patent EP1572962.
JD214696 - Sequence 195720 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K951, ADNP2_HUMAN, KIAA0863, NM_014913, NP_055728, O94943, Q6IQ32, Q9H9P3, ZNF508
UCSC ID: uc002lnw.3
RefSeq Accession: NM_014913
Protein: Q6IQ32 (aka ADNP2_HUMAN)
CCDS: CCDS32853.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014913.3
exon count: 4CDS single in 3' UTR: no RNA size: 5401
ORF size: 3396CDS single in intron: no Alignment % ID: 99.98
txCdsPredict score: 6754.50frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.