Human Gene CHORDC1 (uc001pdg.2) Description and Page Index
  Description: Homo sapiens cysteine and histidine-rich domain (CHORD) containing 1 (CHORDC1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:89,933,597-89,956,532 Size: 22,936 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr11:89,935,573-89,956,122 Size: 20,550 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:89,933,597-89,956,532)mRNA (may differ from genome)Protein (332 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CHRD1_HUMAN
DESCRIPTION: RecName: Full=Cysteine and histidine-rich domain-containing protein 1; AltName: Full=CHORD domain-containing protein 1; Short=CHORD-containing protein 1; Short=CHP-1; AltName: Full=Protein morgana;
FUNCTION: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
SUBUNIT: Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C (By similarity).
INTERACTION: P07900:HSP90AA1; NbExp=8; IntAct=EBI-2550959, EBI-296047;
TISSUE SPECIFICITY: Underexpressed in many breast and lung cancers.
SIMILARITY: Contains 2 CHORD domains.
SIMILARITY: Contains 1 CS domain.
SEQUENCE CAUTION: Sequence=AAH17789.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CHORDC1
CDC HuGE Published Literature: CHORDC1
Positive Disease Associations: Alzheimer Disease , Blood Pressure , Body Mass Index , Body Weights and Measures , Bone Density , C-Reactive Protein , Cholesterol, HDL , Coronary Artery Disease , Creatinine , Erythrocytes , Glomerular Filtration Rate , Hip , HIV-1 , Insulin , Mortality , Parkinson Disease , Receptors, Tumor Necrosis Factor, Type II , Stroke
Related Studies:
  1. Alzheimer Disease
    , , . [PubMed 0]
  2. Blood Pressure
    , , . [PubMed 0]
  3. Blood Pressure
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000255 Adenosine Triphosphate
  • D013749 Tetrachlorodibenzodioxin
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C049325 1,2-dithiol-3-thione
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C009505 4,4'-diaminodiphenylmethane
  • C035207 4-amino-2,6-dinitrotoluene
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.10 RPKM in Pituitary
Total median expression: 222.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -150.10410-0.366 Picture PostScript Text
3' UTR -455.681976-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007051 - CHORD
IPR007052 - CS-like_domain
IPR017447 - CS_domain
IPR008978 - HSP20-like_chaperone

Pfam Domains:
PF04968 - CHORD
PF04969 - CS domain

SCOP Domains:
49764 - HSP20-like chaperones

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2YRT
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9UHD1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0051879 Hsp90 protein binding

Biological Process:
GO:0010824 regulation of centrosome duplication
GO:0061077 chaperone-mediated protein folding
GO:1900034 regulation of cellular response to heat
GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  HQ447579 - Synthetic construct Homo sapiens clone IMAGE:100070921; CCSB014651_01 cysteine and histidine-rich domain (CHORD)-containing 1 (CHORDC1) gene, encodes complete protein.
KJ893582 - Synthetic construct Homo sapiens clone ccsbBroadEn_02976 CHORDC1 gene, encodes complete protein.
LF208375 - JP 2014500723-A/15878: Polycomb-Associated Non-Coding RNAs.
BC002339 - Homo sapiens cDNA clone IMAGE:2820113, containing frame-shift errors.
AF217505 - Homo sapiens uncharacterized bone marrow protein BM028 mRNA, complete cds.
BC072461 - Homo sapiens cysteine and histidine-rich domain (CHORD)-containing 1, mRNA (cDNA clone MGC:90311 IMAGE:6471725), complete cds.
AF192466 - Homo sapiens CHORD containing protein-1 (CHP1) mRNA, complete cds.
AK226099 - Homo sapiens mRNA for cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1 variant, clone: fh21196.
AF123249 - Homo sapiens chymotrypsin-like protein mRNA, complete cds.
AK225365 - Homo sapiens mRNA for cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1 variant, clone: HEP15928.
BC017789 - Homo sapiens cysteine and histidine-rich domain (CHORD)-containing 1, mRNA (cDNA clone IMAGE:4286875), complete cds.
AK225565 - Homo sapiens mRNA for cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1 variant, clone: LNG00337.
JD245063 - Sequence 226087 from Patent EP1572962.
JD432767 - Sequence 413791 from Patent EP1572962.
LF375638 - JP 2014500723-A/183141: Polycomb-Associated Non-Coding RNAs.
LF375637 - JP 2014500723-A/183140: Polycomb-Associated Non-Coding RNAs.
AK290231 - Homo sapiens cDNA FLJ77875 complete cds, highly similar to Homo sapiens CHORD containing protein-1 (CHP1) mRNA.
JD449621 - Sequence 430645 from Patent EP1572962.
JD170422 - Sequence 151446 from Patent EP1572962.
AK312663 - Homo sapiens cDNA, FLJ93053, highly similar to Homo sapiens cysteine and histidine-rich domain (CHORD)-containing 1 (CHORDC1), mRNA.
LF375636 - JP 2014500723-A/183139: Polycomb-Associated Non-Coding RNAs.
CU687242 - Synthetic construct Homo sapiens gateway clone IMAGE:100022953 5' read CHORDC1 mRNA.
LF375635 - JP 2014500723-A/183138: Polycomb-Associated Non-Coding RNAs.
AK094608 - Homo sapiens cDNA FLJ37289 fis, clone BRAMY2014462.
LF375634 - JP 2014500723-A/183137: Polycomb-Associated Non-Coding RNAs.
LF375630 - JP 2014500723-A/183133: Polycomb-Associated Non-Coding RNAs.
LF375628 - JP 2014500723-A/183131: Polycomb-Associated Non-Coding RNAs.
MA443952 - JP 2018138019-A/15878: Polycomb-Associated Non-Coding RNAs.
MA611215 - JP 2018138019-A/183141: Polycomb-Associated Non-Coding RNAs.
MA611214 - JP 2018138019-A/183140: Polycomb-Associated Non-Coding RNAs.
MA611213 - JP 2018138019-A/183139: Polycomb-Associated Non-Coding RNAs.
MA611212 - JP 2018138019-A/183138: Polycomb-Associated Non-Coding RNAs.
MA611211 - JP 2018138019-A/183137: Polycomb-Associated Non-Coding RNAs.
MA611207 - JP 2018138019-A/183133: Polycomb-Associated Non-Coding RNAs.
MA611205 - JP 2018138019-A/183131: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6P8, CHP1, CHRD1_HUMAN, NM_012124, NP_036256, Q6IN49, Q8WVL9, Q9H3D6, Q9UHD1
UCSC ID: uc001pdg.2
RefSeq Accession: NM_012124
Protein: Q9UHD1 (aka CHRD1_HUMAN)
CCDS: CCDS8289.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_012124.2
exon count: 11CDS single in 3' UTR: no RNA size: 3400
ORF size: 999CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1984.00frame shift in genome: no % Coverage: 99.56
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.