Human Gene ATG4B (uc002wbv.3) Description and Page Index
Description: Homo sapiens autophagy related 4B, cysteine peptidase (ATG4B), transcript variant 1, mRNA. RefSeq Summary (NM_013325): Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:242,577,027-242,613,271 Size: 36,245 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr2:242,577,130-242,611,679 Size: 34,550 Coding Exon Count: 13
ID:ATG4B_HUMAN DESCRIPTION: RecName: Full=Cysteine protease ATG4B; EC=3.4.22.-; AltName: Full=AUT-like 1 cysteine endopeptidase; AltName: Full=Autophagin-1; AltName: Full=Autophagy-related cysteine endopeptidase 1; AltName: Full=Autophagy-related protein 4 homolog B; Short=hAPG4B; FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling. ENZYME REGULATION: Inhibited by N-ethylmaleimide. INTERACTION: O95166:GABARAP; NbExp=8; IntAct=EBI-712014, EBI-712001; Q9H0R8:GABARAPL1; NbExp=7; IntAct=EBI-712014, EBI-746969; P60520:GABARAPL2; NbExp=5; IntAct=EBI-712014, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=6; IntAct=EBI-712014, EBI-373144; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. SIMILARITY: Belongs to the peptidase C54 family. SEQUENCE CAUTION: Sequence=BAA76787.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86110.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y4P1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.