Human Gene GRB2 (uc002jnx.4) Description and Page Index
  Description: Homo sapiens growth factor receptor-bound protein 2 (GRB2), transcript variant 1, mRNA.
RefSeq Summary (NM_002086): The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr17:73,314,157-73,401,790 Size: 87,634 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr17:73,316,449-73,389,709 Size: 73,261 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:73,314,157-73,401,790)mRNA (may differ from genome)Protein (217 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDHuman Cortex Gene ExpressionLynx
MGIneXtProtOMIMPubMedReactomeStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=Protein Ash; AltName: Full=SH2/SH3 adapter GRB2;
FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
FUNCTION: Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
SUBUNIT: Associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Interacts with phosphorylated TOM1L1 and MET. Interacts with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation. Interacts with NISCH, PTPNS1, REPS2 and the syntrophin SNTA1. Interacts with REPS1 and PIK3C2B via its SH3 domains (By similarity). Interacts with HCV NS5A via its SH3 domains. Interacts with CBL and CBLB. Interacts with AJUBA and CLNK (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2. Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1. Interacts with PTPN11. Interacts with PRNP and THEMIS (By similarity). Interacts with FLT1 (tyrosine phosphorylated) and KDR. Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Interacts with RALGPS1 and with HCST. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with GAPT and PTPRE. Interacts (via SH2 domain) with KIF26A. Interacts (via SH3 2) with GAB2. Interacts with ADAM15. Interacts with THEMIS2. Interacts (via SH2 domain) with AXL and KIT (phosphorylated). Interacts with PTPRJ and BCR. Interacts with FLT4 (tyrosine phosphorylated). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PTPN23. Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL, in which GRB2 promotes RTK recruitment by TNK2. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with ERBB4. Interacts with NTRK1 (phosphorylated upon ligand-binding). Interacts with PTK2/FAK1 (tyrosine phosphorylated). Interacts with PTK2B/PYK2 (tyrosine phosphorylated). Isoform 1 interacts with SCIMP. Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with TESPA1 and DAB2.
INTERACTION: Self; NbExp=4; IntAct=EBI-401755, EBI-401755; O92972:- (xeno); NbExp=2; IntAct=EBI-401755, EBI-710506; P27958:- (xeno); NbExp=3; IntAct=EBI-401755, EBI-706378; P42684:ABL2; NbExp=2; IntAct=EBI-401755, EBI-1102694; Q15109:AGER; NbExp=2; IntAct=EBI-401755, EBI-1646426; Q01484:ANK2; NbExp=2; IntAct=EBI-401755, EBI-941975; Q9ULH1:ASAP1; NbExp=7; IntAct=EBI-401755, EBI-346622; O43150:ASAP2; NbExp=3; IntAct=EBI-401755, EBI-310968; O60885:BRD4; NbExp=2; IntAct=EBI-401755, EBI-723869; P22681:CBL; NbExp=4; IntAct=EBI-401755, EBI-518228; Q13191:CBLB; NbExp=4; IntAct=EBI-401755, EBI-744027; Q9Y5K6:CD2AP; NbExp=3; IntAct=EBI-401755, EBI-298152; Q8WX92:COBRA1; NbExp=2; IntAct=EBI-401755, EBI-347721; P98082:DAB2; NbExp=2; IntAct=EBI-401755, EBI-1171238; P98078:Dab2 (xeno); NbExp=4; IntAct=EBI-401755, EBI-1391846; P14868:DARS; NbExp=2; IntAct=EBI-401755, EBI-358730; O14490:DLGAP1; NbExp=3; IntAct=EBI-401755, EBI-1753207; Q9P1A6:DLGAP2; NbExp=2; IntAct=EBI-401755, EBI-1753397; Q9Y2H0:DLGAP4; NbExp=2; IntAct=EBI-401755, EBI-722139; Q05193:DNM1; NbExp=3; IntAct=EBI-401755, EBI-713135; Q14185:DOCK1; NbExp=2; IntAct=EBI-401755, EBI-446740; P00533:EGFR; NbExp=12; IntAct=EBI-401755, EBI-297353; P54762:EPHB1; NbExp=2; IntAct=EBI-401755, EBI-80252; Q9UJM3:ERRFI1; NbExp=4; IntAct=EBI-401755, EBI-2941912; Q9H706:FAM59A; NbExp=3; IntAct=EBI-401755, EBI-3440103; O15360:FANCA; NbExp=2; IntAct=EBI-401755, EBI-81570; P21802:FGFR2; NbExp=5; IntAct=EBI-401755, EBI-1028658; P21333:FLNA; NbExp=2; IntAct=EBI-401755, EBI-350432; O75369:FLNB; NbExp=2; IntAct=EBI-401755, EBI-352089; Q14315:FLNC; NbExp=2; IntAct=EBI-401755, EBI-489954; Q9UQC2:GAB2; NbExp=4; IntAct=EBI-401755, EBI-975200; Q07666:KHDRBS1; NbExp=8; IntAct=EBI-401755, EBI-1364; P10721:KIT; NbExp=2; IntAct=EBI-401755, EBI-1379503; P05787:KRT8; NbExp=3; IntAct=EBI-401755, EBI-297852; P48357:LEPR; NbExp=3; IntAct=EBI-401755, EBI-518596; Q13163:MAP2K5; NbExp=2; IntAct=EBI-401755, EBI-307294; Q92918:MAP4K1; NbExp=2; IntAct=EBI-401755, EBI-881; Q8IVH8:MAP4K3; NbExp=2; IntAct=EBI-401755, EBI-1758170; Q9Y4K4:MAP4K5; NbExp=4; IntAct=EBI-401755, EBI-1279; Q9H204:MED28; NbExp=3; IntAct=EBI-401755, EBI-514199; O00750:PIK3C2B; NbExp=2; IntAct=EBI-401755, EBI-641107; P27986:PIK3R1; NbExp=3; IntAct=EBI-401755, EBI-79464; O00459:PIK3R2; NbExp=4; IntAct=EBI-401755, EBI-346930; O14939:PLD2; NbExp=4; IntAct=EBI-401755, EBI-1053996; Q08209:PPP3CA; NbExp=2; IntAct=EBI-401755, EBI-352922; Q9Y478:PRKAB1; NbExp=2; IntAct=EBI-401755, EBI-719769; Q06124:PTPN11; NbExp=6; IntAct=EBI-401755, EBI-297779; Q9H3S7:PTPN23; NbExp=6; IntAct=EBI-401755, EBI-724478; Q8IWN7:RP1L1; NbExp=2; IntAct=EBI-401755, EBI-1757848; Q15427:SF3B4; NbExp=2; IntAct=EBI-401755, EBI-348469; Q9UPX8:SHANK2; NbExp=2; IntAct=EBI-401755, EBI-1570571; Q9BYB0:SHANK3; NbExp=2; IntAct=EBI-401755, EBI-1752330; P29353:SHC1; NbExp=8; IntAct=EBI-401755, EBI-78835; Q07889:SOS1; NbExp=9; IntAct=EBI-401755, EBI-297487; Q62245:Sos1 (xeno); NbExp=2; IntAct=EBI-401755, EBI-1693; Q07890:SOS2; NbExp=6; IntAct=EBI-401755, EBI-298181; O95630:STAMBP; NbExp=3; IntAct=EBI-401755, EBI-396676; O15056:SYNJ2; NbExp=2; IntAct=EBI-401755, EBI-310513; Q92973:TNPO1; NbExp=2; IntAct=EBI-401755, EBI-286693; Q9ULW0:TPX2; NbExp=2; IntAct=EBI-401755, EBI-1037322; Q16851:UGP2; NbExp=2; IntAct=EBI-401755, EBI-743729; P15498:VAV1; NbExp=2; IntAct=EBI-401755, EBI-625518; Q9UKW4:VAV3; NbExp=5; IntAct=EBI-401755, EBI-297568; O00401:WASL; NbExp=3; IntAct=EBI-401755, EBI-957615; O43516:WIPF1; NbExp=3; IntAct=EBI-401755, EBI-346356; Q8TF74:WIPF2; NbExp=3; IntAct=EBI-401755, EBI-2850112;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endosome. Golgi apparatus (By similarity).
DOMAIN: The SH3 domains mediate interaction with RALGPS1 and SHB.
SIMILARITY: Belongs to the GRB2/sem-5/DRK family.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 2 SH3 domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GRB2
CDC HuGE Published Literature: GRB2
Positive Disease Associations: Neuroblastoma
Related Studies:
  1. Neuroblastoma
    John M Maris et al. The New England journal of medicine 2008, Chromosome 6p22 locus associated with clinically aggressive neuroblastoma., The New England journal of medicine. [PubMed 18463370]
    A common genetic variation at chromosome band 6p22 is associated with susceptibility to neuroblastoma.

-  MalaCards Disease Associations
  MalaCards Gene Search: GRB2
Diseases sorted by gene-association score: wiskott-aldrich syndrome (4), hepatocellular carcinoma (3), silver-russell syndrome (2), breast cancer (2), leukemia, chronic myeloid, somatic (2), prostate cancer (1), hypotropia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 75.16 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1418.43 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.91358-0.491 Picture PostScript Text
3' UTR -817.732292-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000108 - p67phox
IPR000980 - SH2
IPR001452 - SH3_domain

Pfam Domains:
PF00017 - SH2 domain
PF00018 - SH3 domain
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help


- X-ray MuPIT

- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1CJ1 - X-ray MuPIT 1FHS - NMR MuPIT 1FYR - X-ray MuPIT
1JYQ - X-ray MuPIT 1JYR - X-ray MuPIT 1JYU - X-ray MuPIT
1QG1 - NMR MuPIT 1TZE - X-ray MuPIT 1X0N - NMR MuPIT
1ZFP - X-ray MuPIT 2AOA - X-ray MuPIT 2AOB - X-ray MuPIT
2H46 - X-ray MuPIT 2H5K - X-ray MuPIT 2HUW - X-ray MuPIT
2VVK - X-ray MuPIT 2VWF - X-ray MuPIT 2W0Z - X-ray MuPIT
3C7I - X-ray MuPIT 3IMD - X-ray MuPIT 3IMJ - X-ray MuPIT
3IN7 - X-ray MuPIT 3IN8 - X-ray MuPIT 3KFJ - X-ray MuPIT
3MXC - X-ray MuPIT 3MXY - X-ray MuPIT 3N7Y - X-ray MuPIT
3N84 - X-ray MuPIT 3N8M - X-ray MuPIT 3OV1 - X-ray MuPIT
3OVE - X-ray MuPIT 3S8L - X-ray MuPIT 3S8N - X-ray MuPIT
3S8O - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P62993
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding
GO:0003723 RNA binding
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043560 insulin receptor substrate binding
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0051219 phosphoprotein binding

Biological Process:
GO:0000165 MAPK cascade
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016032 viral process
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030154 cell differentiation
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031623 receptor internalization
GO:0035635 entry of bacterium into host cell
GO:0035723 interleukin-15-mediated signaling pathway
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042770 signal transduction in response to DNA damage
GO:0043408 regulation of MAPK cascade
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050900 leukocyte migration
GO:0051291 protein heterooligomerization
GO:0051897 positive regulation of protein kinase B signaling
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0061024 membrane organization
GO:0071479 cellular response to ionizing radiation
GO:2000379 positive regulation of reactive oxygen species metabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032991 macromolecular complex
GO:0070062 extracellular exosome
GO:0070436 Grb2-EGFR complex

-  Descriptions from all associated GenBank mRNAs
  AK091010 - Homo sapiens cDNA FLJ33691 fis, clone BRAWH2002976, highly similar to GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2.
BC000631 - Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone MGC:1737 IMAGE:3345524), complete cds.
AK315565 - Homo sapiens cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA.
AF302079 - Homo sapiens HSP22-like protein interacting protein 17 mRNA, complete cds.
AF171699 - Homo sapiens MSTP084 (MST084) mRNA, complete cds.
BC033644 - Homo sapiens cDNA clone IMAGE:5563069.
AK024539 - Homo sapiens cDNA: FLJ20886 fis, clone ADKA03257.
BC043007 - Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone IMAGE:5417009).
BC009417 - Homo sapiens cDNA clone IMAGE:3535598.
AF246238 - Homo sapiens HT027 mRNA, complete cds.
BC019082 - Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone IMAGE:4649400).
BC039827 - Homo sapiens growth factor receptor-bound protein 2, mRNA (cDNA clone IMAGE:6044508), with apparent retained intron.
JD249184 - Sequence 230208 from Patent EP1572962.
JD163939 - Sequence 144963 from Patent EP1572962.
JD402330 - Sequence 383354 from Patent EP1572962.
JD253427 - Sequence 234451 from Patent EP1572962.
JD158033 - Sequence 139057 from Patent EP1572962.
JD388664 - Sequence 369688 from Patent EP1572962.
JD090436 - Sequence 71460 from Patent EP1572962.
DL492519 - Novel nucleic acids.
DL490988 - Novel nucleic acids.
JD264441 - Sequence 245465 from Patent EP1572962.
JD496221 - Sequence 477245 from Patent EP1572962.
JD347530 - Sequence 328554 from Patent EP1572962.
JD060288 - Sequence 41312 from Patent EP1572962.
JD308720 - Sequence 289744 from Patent EP1572962.
JD445324 - Sequence 426348 from Patent EP1572962.
JD165829 - Sequence 146853 from Patent EP1572962.
JD237636 - Sequence 218660 from Patent EP1572962.
DQ572769 - Homo sapiens piRNA piR-40881, complete sequence.
JD522230 - Sequence 503254 from Patent EP1572962.
JD556276 - Sequence 537300 from Patent EP1572962.
JD053544 - Sequence 34568 from Patent EP1572962.
JD053543 - Sequence 34567 from Patent EP1572962.
JD492639 - Sequence 473663 from Patent EP1572962.
DQ586711 - Homo sapiens piRNA piR-53823, complete sequence.
L29511 - Human GRB2 isoform mRNA.
M96995 - Homo sapiens epidermal growth factor receptor-binding protein GRB2 (EGFRBP-GRB2) mRNA sequence.
X62852 - H.sapiens ash mRNA.
JD195056 - Sequence 176080 from Patent EP1572962.
JD096928 - Sequence 77952 from Patent EP1572962.
JD260153 - Sequence 241177 from Patent EP1572962.
JD091148 - Sequence 72172 from Patent EP1572962.
JD284110 - Sequence 265134 from Patent EP1572962.
AF498925 - Homo sapiens growth factor receptor-bound protein 2 (GRB2) mRNA, complete cds.
CR541942 - Homo sapiens full open reading frame cDNA clone RZPDo834A0934D for gene GRB2, growth factor receptor-bound protein 2; complete cds, incl. stopcodon.
DQ891830 - Synthetic construct clone IMAGE:100004460; FLH180369.01X; RZPDo839B06134D growth factor receptor-bound protein 2 (GRB2) gene, encodes complete protein.
DQ894923 - Synthetic construct Homo sapiens clone IMAGE:100009383; FLH180365.01L; RZPDo839B06133D growth factor receptor-bound protein 2 (GRB2) gene, encodes complete protein.
KJ891294 - Synthetic construct Homo sapiens clone ccsbBroadEn_00688 GRB2 gene, encodes complete protein.
AB385058 - Synthetic construct DNA, clone: pF1KB5162, Homo sapiens GRB2 gene for growth factor receptor-bound protein 2, complete cds, without stop codon, in Flexi system.
CR450363 - Homo sapiens full open reading frame cDNA clone RZPDo834D113D for gene GRB2, growth factor receptor-bound protein 2; complete cds; without stopcodon.
GQ901029 - Homo sapiens clone HEL-T-141 epididymis secretory sperm binding protein mRNA, partial cds.
CU674310 - Synthetic construct Homo sapiens gateway clone IMAGE:100017610 5' read GRB2 mRNA.
JD176857 - Sequence 157881 from Patent EP1572962.
JD416863 - Sequence 397887 from Patent EP1572962.
JD424408 - Sequence 405432 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04320 - Dorso-ventral axis formation
hsa04510 - Focal adhesion
hsa04540 - Gap junction
hsa04630 - Jak-STAT signaling pathway
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04722 - Neurotrophin signaling pathway
hsa04910 - Insulin signaling pathway
hsa04912 - GnRH signaling pathway
hsa05200 - Pathways in cancer
hsa05211 - Renal cell carcinoma
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_egfPathway - EGF Signaling Pathway
h_epoPathway - EPO Signaling Pathway
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_crebPathway - Transcription factor CREB and its extracellular signals
h_ghPathway - Growth Hormone Signaling Pathway
h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
h_il2Pathway - IL 2 signaling pathway
h_insulinPathway - Insulin Signaling Pathway
h_bcrPathway - BCR Signaling Pathway
h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_integrinPathway - Integrin Signaling Pathway
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_ngfPathway - Nerve growth factor pathway (NGF)
h_pdgfPathway - PDGF Signaling Pathway
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_spryPathway - Sprouty regulation of tyrosine kinase signals
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_TPOPathway - TPO Signaling Pathway
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_igf1Pathway - IGF-1 Signaling Pathway
h_il4Pathway - IL 4 signaling pathway
h_srcRPTPPathway - Activation of Src by Protein-tyrosine phosphatase alpha
h_trkaPathway - Trka Receptor Signaling Pathway
h_il3Pathway - IL 3 signaling pathway
h_il6Pathway - IL 6 signaling pathway
h_mapkPathway - MAPKinase Signaling Pathway
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_tcrPathway - T Cell Receptor Signaling Pathway
h_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein P62993 (Reactome details) participates in the following event(s):

R-HSA-109813 GRB2-1 binds SOS1
R-HSA-177920 Binding of GRB2 to GAB1
R-HSA-183052 CBL binds to GRB2
R-HSA-204871 Interaction of Tie2 and Grb2
R-HSA-354087 Recruitment of GRB2 to p-FADK1
R-HSA-388814 Grb2 binds CD28
R-HSA-389919 Grb2 binds pBTLA
R-HSA-391153 p-4Y-SIRPA:CD47 binds GRB2-1
R-HSA-392051 Recruitment of Grb2 to pFAK:NCAM1
R-HSA-879917 CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2
R-HSA-914022 SHP2 can recruit GRB2
R-HSA-1295613 SPRY2 binds GRB2
R-HSA-1433428 GRB2 is indirectly recruited to p-KIT through SHP2
R-HSA-8851919 Activated MET binds GAB1 and GRB2
R-HSA-1549564 PPTN11 dephosphorylates SPRY2
R-HSA-74736 GRB2-1:SOS1 binds p-IRS1,p-IRS2
R-HSA-74746 GRB2-1:SOS1 binds p-Y427-SHC1
R-HSA-177936 GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
R-HSA-177943 GRB2:SOS1 complex binds to EGF:EGFR complex
R-HSA-186826 Grb2/Sos1 complex binds to the active receptor
R-HSA-205286 GRB2:SOS interacts with p-KIT
R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1
R-HSA-1225950 Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants
R-HSA-1225961 Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
R-HSA-1250380 Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
R-HSA-1250486 Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
R-HSA-1250488 GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
R-HSA-1306969 GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
R-HSA-2179415 GRB2:SOS1 binds to HBEGF:p-Y-EGFR
R-HSA-2730844 Interaction of GRB2:SOS complex with p-SHC1
R-HSA-5637770 Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII
R-HSA-5637798 Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5654416 Activated FGFR3:pFRS binds GRB2:SOS1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-5654586 Activated FGFR1:p-FRS binds GRB2:SOS1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5654664 Activated FGFR4:p-FRS binds GRB2:SOS1
R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655266 Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655295 Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655348 Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5685366 GRB2-1:SOS1 binds p-Y-SHC
R-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1
R-HSA-8851804 Activated MET recruits GRB2-1:SOS1
R-HSA-8851900 SHC1-2 bound to MET recruits GRB2:SOS1
R-HSA-8853314 Activated FGFR3 fusions:p-FRS2 bind GRB2-SOS1
R-HSA-8853734 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
R-HSA-8854899 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
R-HSA-9028328 SHC1 bound to activated NTRK2 recruits GRB2:SOS1
R-HSA-5686074 GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates
R-HSA-5686315 GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
R-HSA-177931 Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
R-HSA-179467 GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
R-HSA-1306963 Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
R-HSA-183067 Localization of CBL:GRB2 to the membrane
R-HSA-8876240 CBL binds InlB-activated MET
R-HSA-183002 Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
R-HSA-8867044 EGFR binds EPS15, EPN1, EPS15L1
R-HSA-182994 Assembly of EGFR complex in clathrin-coated vesicles
R-HSA-183036 Ubiquitination of stimulated EGFR (CBL:GRB2)
R-HSA-183058 Phosphorylation of CBL (EGFR:GRB2:CBL)
R-HSA-5654673 p-CBL:GRB2 binds p-FRS2:activated FGFR1
R-HSA-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-HSA-5654730 p-CBL:GRB2 binds p-FRS2:activated FGFR3
R-HSA-5654734 p-CBL:GRB2 binds p-FRS2:activated FGFR4
R-HSA-210974 Interaction of SOS-1 to Tie2 bound Grb2
R-HSA-354165 Interaction of SOS with GRB2 bound to FADK1
R-HSA-389352 Translocation of Vav1 to CD28
R-HSA-1839095 p-BCR-pFGFR1 binds GRB2:GAB2
R-HSA-912629 CBL is tyrosine phosphorylated
R-HSA-983703 p-6Y-SYK phosphorylates BLNK (SLP65)
R-NUL-1250475 Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer
R-NUL-1250500 Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex
R-HSA-205234 Indirect recruitment of GAB2 to p-KIT
R-HSA-2197691 Activation of WASP/N-WASP by WIP family and SH3 domain proteins
R-HSA-109822 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
R-HSA-109823 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
R-HSA-2396599 Recruitment of GRB2:SOS to p-5Y-LAT
R-HSA-2730837 Recruitment of GRB2:SOS to p-10Y-NTAL
R-HSA-1226016 Binding of GRB2:GAB1:PIK3R1 complex to ligand-responsive p-6Y-EGFR mutants
R-HSA-5637764 Binding of GRB2:GAB1:PIK3R1 complex to p-EGFRvIII mutant
R-HSA-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5655240 Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655248 Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655315 Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-8853316 Activated FGFR3 fusions:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-1306965 Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
R-HSA-177941 GRB2:GAB1 binds to phosphorylated EGFR
R-HSA-183084 CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
R-HSA-8876246 InlB-activated MET phosphorylates CBL
R-HSA-8874685 CBL binds MET
R-HSA-8867041 EGFR phosphorylates EPS15
R-HSA-8867047 PTPN3 dephosphorylates EPS15
R-HSA-8951490 CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
R-HSA-5654672 CBL ubiquitinates FRS2 and FGFR1
R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2
R-HSA-5654679 CBL ubiquitinates FRS2 and FGFR3
R-HSA-5654684 CBL ubiquitinates FRS2 and FGFR4
R-HSA-389354 Activation of Vav1
R-HSA-392053 SOS binds Grb2 bound to pFAK:NCAM1
R-HSA-1839110 p-BCR-p-FGFR1 phosphorylates GAB2
R-HSA-1839114 BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1
R-HSA-1562641 Indirect recruitment of PI3K to KIT via p(Y)-GAB2
R-HSA-8851933 MET phosphorylates GAB1
R-HSA-8851954 Phosphorylated GAB1 recruits PI3K to MET
R-HSA-8865994 GAB1 binds PTPN11
R-HSA-8875540 GAB1 recruits CRK,CRKL to MET
R-HSA-8866279 Epsin family proteins bind ubiquitinated cargo
R-HSA-8876258 CBL monoubiquitinates InlB-bound MET
R-HSA-8876255 CBL recruits CIN85:endophilin complex to InlB-bound MET
R-HSA-2197698 Phosphorylation of WASP/N-WASP
R-HSA-2076220 CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
R-HSA-109807 GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
R-HSA-109817 GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
R-HSA-177938 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
R-HSA-186834 Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)
R-HSA-205244 Recruitment of CBL to KIT
R-HSA-1433471 Activation of RAS by p-KIT bound SOS1
R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
R-HSA-1225951 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
R-HSA-1250383 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
R-HSA-1250463 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
R-HSA-1250498 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
R-HSA-1306972 RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
R-HSA-2179407 SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
R-HSA-2396561 Recruitment of GADS:SLP-76 to p-5Y-LAT
R-HSA-2730848 Recruitment of GAB2 to PM and FCERI by binding to GRB2
R-HSA-5637806 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655347 Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
R-HSA-8851827 RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
R-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
R-HSA-8853307 FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-9026891 NTRK2 activates RAS signaling through SHC1
R-HSA-1226012 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and ligand-responsive p-6Y-EGFR mutants
R-HSA-5637765 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFRvIII
R-HSA-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-HSA-5655263 Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5655285 Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5655252 Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-8853308 Activated FGFR3 fusions:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-177930 GAB1 phosphorylation by EGFR kinase
R-HSA-177927 PI3K binds to EGF:EGFR:GRB2:GAB1
R-HSA-177944 Activation of SHP2 through the binding to phospho-Gab1
R-HSA-177935 SHP2 dephosphorylates Tyr 992 on EGFR
R-HSA-177924 Dephosphorylation of Gab1 by SHP2
R-HSA-8875451 MET phosphorylates CBL
R-HSA-210977 Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
R-HSA-389348 Activation of Rac1 by pVav1
R-HSA-389350 Activation of Cdc42 by pVav1
R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases
R-HSA-1839102 BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
R-NUL-1250468 Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut
R-NUL-1250472 Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut
R-HSA-8875558 RAPGEF1 binds CRK,CRKL
R-HSA-8855508 p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
R-HSA-8876262 EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB
R-HSA-8875183 CBL monoubiquitinates activated MET
R-HSA-8875482 CBL recruits CIN85:endophilin to ubiquitinated MET
R-HSA-442592 WASPs or WAVEs activate the ARP2/3 complex
R-HSA-2197690 Detachment of WASP/WAVE
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-2424485 Release of p-PLCG1
R-HSA-2424481 Recruitment of VAV and BTK to p-SLP-76
R-HSA-2730892 Recruitment of VAV to p-SLP-76
R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK
R-HSA-2730851 Phosphorylation of SLP-76 by p-SYK
R-HSA-2396606 Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
R-HSA-2424477 SOS mediated nucleotide exchange of RAS (SHC)
R-HSA-2730842 PI3K associates with phosphorylated GAB2
R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K
R-HSA-8852019 MET bound PI3K generates PIP3
R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
R-HSA-2029466 Attachment of preexisting mother filament and initiation of branching
R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK
R-HSA-2424484 Phosphorylation of BTK by p-SYK
R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK
R-HSA-2730888 Phosphorylation of PLC-gamma
R-HSA-2730858 Autophosphorylation of BTK/ITK
R-HSA-2730840 Activation of RAC1 by VAV
R-HSA-2730841 Phosphorylation and activation of VAV
R-HSA-2730885 Recruitment of TEC kinases to p-SLP-76
R-HSA-2730833 Phosphorylation of TEC kinases by p-SYK
R-HSA-2730889 Recruitment of PAK to the membrane by binding active RAC1
R-HSA-2730856 Autophosphorylation of PAK
R-HSA-1226014 Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
R-HSA-5637801 Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655290 Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655235 Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-8853323 Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-1306957 PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
R-HSA-177939 PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
R-HSA-177923 Sustained activation of SRC kinase by SHP2
R-HSA-177926 Dephosphorylation of PAG by SHP2
R-HSA-1839107 BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
R-HSA-8875568 RAPGEF1 activates RAP1
R-HSA-8868071 Clathrin recruits PIK3C2A
R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission
R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P
R-HSA-8875490 EPS15 and HGS bind ubiquitinated MET
R-HSA-8871194 RAB5 and GAPVD1 bind AP-2
R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle
R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
R-HSA-2424476 Activation of RAC1 by VAV2/3
R-HSA-2730847 Hydrolysis of PIP2 by PLCG
R-HSA-2730870 Phosphorylation of PIP2 to PIP3 by PI3K
R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit
R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery
R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
R-HSA-8868236 BAR domain proteins recruit dynamin
R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180292 GAB1 signalosome
R-HSA-182971 EGFR downregulation
R-HSA-210993 Tie2 Signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-388841 Costimulation by the CD28 family
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-912631 Regulation of signaling by CBL
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8853659 RET signaling
R-HSA-112412 SOS-mediated signalling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-167044 Signalling to RAS
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-74749 Signal attenuation
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-74752 Signaling by Insulin receptor
R-HSA-177929 Signaling by EGFR
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-389356 CD28 co-stimulation
R-HSA-1280218 Adaptive Immune System
R-HSA-1500931 Cell-Cell communication
R-HSA-422475 Axon guidance
R-HSA-451927 Interleukin-2 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-6806834 Signaling by MET
R-HSA-2424491 DAP12 signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-112399 IRS-mediated signalling
R-HSA-186797 Signaling by PDGF
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-1236394 Signaling by ERBB4
R-HSA-1227986 Signaling by ERBB2
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-187687 Signalling to ERKs
R-HSA-2428924 IGF1R signaling cascade
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-6807004 Negative regulation of MET activity
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-8865999 MET activates PTPN11
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-195258 RHO GTPase Effectors
R-HSA-109582 Hemostasis
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-168256 Immune System
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1433559 Regulation of KIT signaling
R-HSA-2172127 DAP12 interactions
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-416476 G alpha (q) signalling events
R-HSA-168249 Innate Immune System
R-HSA-5663202 Diseases of signal transduction
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-166520 Signaling by NTRKs
R-HSA-5663205 Infectious disease
R-HSA-190236 Signaling by FGFR
R-HSA-8875656 MET receptor recycling
R-HSA-8875878 MET promotes cell motility
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-194315 Signaling by Rho GTPases
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-388396 GPCR downstream signalling
R-HSA-1643685 Disease
R-HSA-109704 PI3K Cascade
R-HSA-199991 Membrane Trafficking
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-372790 Signaling by GPCR
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5683057 MAPK family signaling cascades
R-HSA-8983394 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
R-HSA-8983432 Interleukin-15 signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ASH, GRB2_HUMAN, NM_002086, NP_002077, P29354, P62993, Q14450, Q63057, Q63059
UCSC ID: uc002jnx.4
RefSeq Accession: NM_002086
Protein: P62993 (aka GRB2_HUMAN)
CCDS: CCDS11721.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_002086.4
exon count: 6CDS single in 3' UTR: no RNA size: 3303
ORF size: 654CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1385.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.