Human Gene MSL1 (uc002hua.4) Description and Page Index
  Description: Homo sapiens male-specific lethal 1 homolog (Drosophila) (MSL1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:38,278,790-38,293,045 Size: 14,256 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr17:38,282,457-38,290,622 Size: 8,166 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:38,278,790-38,293,045)mRNA (may differ from genome)Protein (351 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Male-specific lethal 1 homolog; Short=MSL-1; AltName: Full=Male-specific lethal 1-like 1; Short=MSL1-like 1; AltName: Full=Male-specific lethal-1 homolog 1;
FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure.
SUBUNIT: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Interacts with MSL2 via its coiled coil domain.
PTM: Sumoylated with SUMO1.
SIMILARITY: Belongs to the msl-1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.64 RPKM in Cervix - Endocervix
Total median expression: 1374.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -141.73341-0.416 Picture PostScript Text
3' UTR -720.192423-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026711 - msl-1

Pfam Domains:
PF15275 - PEHE domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q68DK7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006325 chromatin organization
GO:0043984 histone H4-K16 acetylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0072487 MSL complex

-  Descriptions from all associated GenBank mRNAs
  AL049450 - Homo sapiens mRNA; cDNA DKFZp586B1922 (from clone DKFZp586B1922).
CR749360 - Homo sapiens mRNA; cDNA DKFZp686J17211 (from clone DKFZp686J17211).
BC118997 - Homo sapiens male-specific lethal 1 homolog (Drosophila), mRNA (cDNA clone MGC:141862 IMAGE:40084759), complete cds.
BC122543 - Homo sapiens male-specific lethal 1 homolog (Drosophila), mRNA (cDNA clone MGC:141861 IMAGE:40084757), complete cds.
EU831932 - Synthetic construct Homo sapiens clone HAIB:100066961; DKFZo008C0923 male-specific lethal-1 homolog protein (MSL-1) gene, encodes complete protein.
EU832027 - Synthetic construct Homo sapiens clone HAIB:100067056; DKFZo004C0924 male-specific lethal-1 homolog protein (MSL-1) gene, encodes complete protein.
KJ896060 - Synthetic construct Homo sapiens clone ccsbBroadEn_05454 MSL1 gene, encodes complete protein.
BC039449 - Homo sapiens male-specific lethal 1 homolog (Drosophila), mRNA (cDNA clone IMAGE:5311571), with apparent retained intron.
AK297619 - Homo sapiens cDNA FLJ54851 complete cds.
AK125654 - Homo sapiens cDNA FLJ43666 fis, clone SYNOV4007012.
AK124185 - Homo sapiens cDNA FLJ42191 fis, clone THYMU2033053.
BX647188 - Homo sapiens mRNA; cDNA DKFZp686P24239 (from clone DKFZp686P24239).
JD127729 - Sequence 108753 from Patent EP1572962.
JD329602 - Sequence 310626 from Patent EP1572962.
JD548932 - Sequence 529956 from Patent EP1572962.
AK055378 - Homo sapiens cDNA FLJ30816 fis, clone FEBRA2001571.
JD181842 - Sequence 162866 from Patent EP1572962.
JD393523 - Sequence 374547 from Patent EP1572962.
JD262623 - Sequence 243647 from Patent EP1572962.
JD046484 - Sequence 27508 from Patent EP1572962.
JD165720 - Sequence 146744 from Patent EP1572962.
JD441979 - Sequence 423003 from Patent EP1572962.
JD168126 - Sequence 149150 from Patent EP1572962.
JD521944 - Sequence 502968 from Patent EP1572962.
JD084686 - Sequence 65710 from Patent EP1572962.
JD349029 - Sequence 330053 from Patent EP1572962.
JD302666 - Sequence 283690 from Patent EP1572962.
JD509786 - Sequence 490810 from Patent EP1572962.
JD486117 - Sequence 467141 from Patent EP1572962.
JD183203 - Sequence 164227 from Patent EP1572962.
JD282851 - Sequence 263875 from Patent EP1572962.
JD186691 - Sequence 167715 from Patent EP1572962.
JD430639 - Sequence 411663 from Patent EP1572962.
JD197457 - Sequence 178481 from Patent EP1572962.
JD510624 - Sequence 491648 from Patent EP1572962.
JD304229 - Sequence 285253 from Patent EP1572962.
JD315281 - Sequence 296305 from Patent EP1572962.
JD305991 - Sequence 287015 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_smPathway - Spliceosomal Assembly

Reactome (by CSHL, EBI, and GO)

Protein Q68DK7 (Reactome details) participates in the following event(s):

R-HSA-3321883 MSL acetylates histone H4
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: MSL1L1, MSL1_HUMAN, NM_001012241, NP_001012241, Q0VF46, Q68DK7, Q69Z03
UCSC ID: uc002hua.4
RefSeq Accession: NM_001012241
Protein: Q68DK7 (aka MSL1_HUMAN)
CCDS: CCDS45670.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001012241.1
exon count: 10CDS single in 3' UTR: no RNA size: 3834
ORF size: 1056CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2051.00frame shift in genome: no % Coverage: 99.63
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.