Human Gene CCNDBP1 (uc001zqv.3) Description and Page Index
Description: Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 1, mRNA. RefSeq Summary (NM_012142): This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]. Transcript (Including UTRs) Position: hg19 chr15:43,477,466-43,489,375 Size: 11,910 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr15:43,477,697-43,487,039 Size: 9,343 Coding Exon Count: 11
ID:CCDB1_HUMAN DESCRIPTION: RecName: Full=Cyclin-D1-binding protein 1; AltName: Full=Grap2 and cyclin-D-interacting protein; AltName: Full=Human homolog of Maid; FUNCTION: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. INTERACTION: Q92905:COPS5; NbExp=5; IntAct=EBI-748961, EBI-594661; P55042:RRAD; NbExp=5; IntAct=EBI-748961, EBI-3911502; P15923-1:TCF3; NbExp=3; IntAct=EBI-748961, EBI-769645; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. DEVELOPMENTAL STAGE: Expression may increase during differentiation. INDUCTION: Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation. PTM: Phosphorylated. SIMILARITY: Belongs to the CCNDBP1 family. SEQUENCE CAUTION: Sequence=AAD11777.1; Type=Frameshift; Positions=8, 14, 18; Sequence=AAP97163.1; Type=Frameshift; Positions=17, 40;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95273
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.