Human Gene CCNDBP1 (uc001zqv.3) Description and Page Index
  Description: Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 1, mRNA.
RefSeq Summary (NM_012142): This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009].
Transcript (Including UTRs)
   Position: hg19 chr15:43,477,466-43,489,375 Size: 11,910 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr15:43,477,697-43,487,039 Size: 9,343 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:43,477,466-43,489,375)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CCDB1_HUMAN
DESCRIPTION: RecName: Full=Cyclin-D1-binding protein 1; AltName: Full=Grap2 and cyclin-D-interacting protein; AltName: Full=Human homolog of Maid;
FUNCTION: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription.
SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.
INTERACTION: Q92905:COPS5; NbExp=5; IntAct=EBI-748961, EBI-594661; P55042:RRAD; NbExp=5; IntAct=EBI-748961, EBI-3911502; P15923-1:TCF3; NbExp=3; IntAct=EBI-748961, EBI-769645;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
DEVELOPMENTAL STAGE: Expression may increase during differentiation.
INDUCTION: Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.
PTM: Phosphorylated.
SIMILARITY: Belongs to the CCNDBP1 family.
SEQUENCE CAUTION: Sequence=AAD11777.1; Type=Frameshift; Positions=8, 14, 18; Sequence=AAP97163.1; Type=Frameshift; Positions=17, 40;

-  MalaCards Disease Associations
  MalaCards Gene Search: CCNDBP1
Diseases sorted by gene-association score: optic disk drusen (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.87 RPKM in Whole Blood
Total median expression: 1293.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -115.30231-0.499 Picture PostScript Text
3' UTR -607.682336-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026907 - CCNDBP1

Pfam Domains:
PF13324 - Grap2 and cyclin-D-interacting

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3AY5
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O95273
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007049 cell cycle
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK308817 - Homo sapiens cDNA, FLJ98858.
LP895306 - Sequence 170 from Patent EP3253886.
JD471734 - Sequence 452758 from Patent EP1572962.
JD471735 - Sequence 452759 from Patent EP1572962.
AK290707 - Homo sapiens cDNA FLJ76710 complete cds, highly similar to Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 2, mRNA.
AF087852 - Homo sapiens Maid mRNA, complete cds.
AF082569 - Homo sapiens D-type cyclin-interacting protein 1 (DIP1) mRNA, complete cds.
BC009689 - Homo sapiens cyclin D-type binding-protein 1, mRNA (cDNA clone MGC:9085 IMAGE:3896421), complete cds.
AK295017 - Homo sapiens cDNA FLJ60254 complete cds, highly similar to Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 2, mRNA.
AK290665 - Homo sapiens cDNA FLJ76126 complete cds, highly similar to Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 1, mRNA.
AK225645 - Homo sapiens mRNA for cyclin D-type binding-protein 1 variant, clone: SPL07863.
AK075146 - Homo sapiens cDNA FLJ90665 fis, clone PLACE1005250, highly similar to Homo sapiens D-type cyclin-interacting protein 1 (DIP1) mRNA.
AF246144 - Homo sapiens grap2 cyclin D interacting protein GCIP mRNA, complete cds.
AK225143 - Homo sapiens mRNA for cyclin D-type binding-protein 1 variant, clone: CBL05862.
AF132034 - Homo sapiens HHM protein mRNA, complete cds.
CU679441 - Synthetic construct Homo sapiens gateway clone IMAGE:100019084 5' read CCNDBP1 mRNA.
AB590193 - Synthetic construct DNA, clone: pFN21AE1558, Homo sapiens CCNDBP1 gene for cyclin D-type binding-protein 1, without stop codon, in Flexi system.
CR450331 - Homo sapiens full open reading frame cDNA clone RZPDo834H081D for gene CCNDBP1, cyclin D-type binding-protein 1; complete cds; without stopcodon.
DQ894124 - Synthetic construct Homo sapiens clone IMAGE:100008584; FLH167982.01L; RZPDo839A0791D cyclin D-type binding-protein 1 (CCNDBP1) gene, encodes complete protein.
KJ893408 - Synthetic construct Homo sapiens clone ccsbBroadEn_02802 CCNDBP1 gene, encodes complete protein.
AK075296 - Homo sapiens cDNA FLJ90815 fis, clone Y79AA1001056.
AF113535 - Homo sapiens MAID protein mRNA, complete cds.
JD110518 - Sequence 91542 from Patent EP1572962.
AK128849 - Homo sapiens cDNA FLJ46628 fis, clone TRACH2011057, highly similar to Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1).
JD500943 - Sequence 481967 from Patent EP1572962.
JD251616 - Sequence 232640 from Patent EP1572962.
AK124193 - Homo sapiens cDNA FLJ42199 fis, clone THYMU2034374, highly similar to Homo sapiens cyclin D-type binding-protein 1 (CCNDBP1), transcript variant 2, mRNA.
JD038711 - Sequence 19735 from Patent EP1572962.
JD189447 - Sequence 170471 from Patent EP1572962.
JD553218 - Sequence 534242 from Patent EP1572962.
JD478714 - Sequence 459738 from Patent EP1572962.
JD487193 - Sequence 468217 from Patent EP1572962.
JD181975 - Sequence 162999 from Patent EP1572962.
JD289887 - Sequence 270911 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3Q0, A8K3U2, CCDB1_HUMAN, DIP1, GCIP, HHM, NM_012142, NP_036274, O95273, Q6ZQN9, Q7Z519, Q8NBS7, Q8NBY2, Q9NS19, Q9NYH3, Q9UHX9
UCSC ID: uc001zqv.3
RefSeq Accession: NM_012142
Protein: O95273 (aka CCDB1_HUMAN)
CCDS: CCDS10092.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_012142.4
exon count: 11CDS single in 3' UTR: no RNA size: 3669
ORF size: 1083CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2194.00frame shift in genome: no % Coverage: 99.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.