Human Gene CWF19L2 (uc010rvp.2) Description and Page Index
  Description: Homo sapiens CWF19-like 2, cell cycle control (S. pombe) (CWF19L2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:107,197,072-107,328,572 Size: 131,501 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr11:107,197,636-107,328,542 Size: 130,907 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:107,197,072-107,328,572)mRNA (may differ from genome)Protein (894 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: C19L2_HUMAN
DESCRIPTION: RecName: Full=CWF19-like protein 2;
SIMILARITY: Belongs to the CWF19 family.
CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
SEQUENCE CAUTION: Sequence=AAI10440.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI10441.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI10441.1; Type=Frameshift; Positions=754; Sequence=AAI10442.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI10443.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI18670.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB71307.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CWF19L2
CDC HuGE Published Literature: CWF19L2
Positive Disease Associations: Calcium-Binding Proteins , Hypertension
Related Studies:
  1. Calcium-Binding Proteins
    Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics. [PubMed 17903293]
    The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
  2. Hypertension
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.34 RPKM in Ovary
Total median expression: 235.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.7030-0.090 Picture PostScript Text
3' UTR -135.79564-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006768 - Cwf19-like_C_dom-1
IPR006767 - Cwf19-like_C_dom-2
IPR011146 - HIT-like

Pfam Domains:
PF04676 - Protein similar to CwfJ C-terminus 2
PF04677 - Protein similar to CwfJ C-terminus 1

ModBase Predicted Comparative 3D Structure on Q2TBE0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  AK056905 - Homo sapiens cDNA FLJ32343 fis, clone PROST2006260, weakly similar to SPLICING FACTOR, ARGININE/SERINE-RICH 4.
AK126881 - Homo sapiens cDNA FLJ44933 fis, clone BRAMY3017827.
BX649022 - Homo sapiens mRNA; cDNA DKFZp779H1334 (from clone DKFZp779H1334).
BX648704 - Homo sapiens mRNA; cDNA DKFZp686N0939 (from clone DKFZp686N0939).
BC056241 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone IMAGE:6495259), partial cds.
BX647832 - Homo sapiens mRNA; cDNA DKFZp779A241 (from clone DKFZp779A241).
AK293001 - Homo sapiens cDNA FLJ77616 complete cds, highly similar to Homo sapiens CWF19-like 2, cell cycle control(CWF19L2), mRNA.
BC110439 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone MGC:118878 IMAGE:40001346), complete cds.
BC110440 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone MGC:118879 IMAGE:40001348), complete cds.
BC110441 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone MGC:118880 IMAGE:40001349), complete cds.
BC110442 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone MGC:118881 IMAGE:40001350), complete cds.
BC118669 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone MGC:141685 IMAGE:40012545), complete cds.
BC016611 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone IMAGE:4477690), with apparent retained intron.
BC028043 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone IMAGE:5392078), complete cds.
JD509701 - Sequence 490725 from Patent EP1572962.
JD302257 - Sequence 283281 from Patent EP1572962.
JD368925 - Sequence 349949 from Patent EP1572962.
JD521791 - Sequence 502815 from Patent EP1572962.
JD417537 - Sequence 398561 from Patent EP1572962.
JD513214 - Sequence 494238 from Patent EP1572962.
JD521149 - Sequence 502173 from Patent EP1572962.
JD060912 - Sequence 41936 from Patent EP1572962.
JD330680 - Sequence 311704 from Patent EP1572962.
BC107418 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone IMAGE:4064343).
BC070142 - Homo sapiens CWF19-like 2, cell cycle control (S. pombe), mRNA (cDNA clone IMAGE:4249136).

-  Other Names for This Gene
  Alternate Gene Symbols: A4FU66, A4FU67, A4FU68, C19L2_HUMAN, NM_152434, NP_689647, Q2TBE0, Q6PHW1, Q96MI1
UCSC ID: uc010rvp.2
RefSeq Accession: NM_152434
Protein: Q2TBE0 (aka C19L2_HUMAN)
CCDS: CCDS8336.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152434.2
exon count: 18CDS single in 3' UTR: no RNA size: 3285
ORF size: 2685CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5567.00frame shift in genome: no % Coverage: 99.82
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.