Human Gene TMEM64 (uc003yen.2) Description and Page Index
  Description: Homo sapiens transmembrane protein 64 (TMEM64), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:91,634,223-91,658,133 Size: 23,911 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr8:91,637,899-91,658,133 Size: 20,235 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:91,634,223-91,658,133)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TMM64_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 64;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TVP38/TMEM64 family.
SEQUENCE CAUTION: Sequence=AAN05737.1; Type=Erroneous initiation; Sequence=CAD39028.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.27 RPKM in Thyroid
Total median expression: 220.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -862.363676-0.235 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015414 - SNARE_assoc

Pfam Domains:
PF09335 - SNARE associated Golgi protein

ModBase Predicted Comparative 3D Structure on Q6YI46
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0043462 regulation of ATPase activity
GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0090090 negative regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF206394 - JP 2014500723-A/13897: Polycomb-Associated Non-Coding RNAs.
BC113828 - Homo sapiens transmembrane protein 64, mRNA (cDNA clone IMAGE:40024272), complete cds.
MA441971 - JP 2018138019-A/13897: Polycomb-Associated Non-Coding RNAs.
AK095472 - Homo sapiens cDNA FLJ38153 fis, clone DFNES1000083.
LF353904 - JP 2014500723-A/161407: Polycomb-Associated Non-Coding RNAs.
LF353902 - JP 2014500723-A/161405: Polycomb-Associated Non-Coding RNAs.
AL834364 - Homo sapiens mRNA; cDNA DKFZp762C1112 (from clone DKFZp762C1112).
BC017409 - Homo sapiens transmembrane protein 64, mRNA (cDNA clone IMAGE:4332938).
AK123958 - Homo sapiens cDNA FLJ41964 fis, clone PUAEN2006701, highly similar to Homo sapiens transmembrane protein 64 (TMEM64), mRNA.
LF353899 - JP 2014500723-A/161402: Polycomb-Associated Non-Coding RNAs.
JD352217 - Sequence 333241 from Patent EP1572962.
LF353898 - JP 2014500723-A/161401: Polycomb-Associated Non-Coding RNAs.
JD022171 - Sequence 3195 from Patent EP1572962.
JD032095 - Sequence 13119 from Patent EP1572962.
JD024498 - Sequence 5522 from Patent EP1572962.
JD033831 - Sequence 14855 from Patent EP1572962.
LF353897 - JP 2014500723-A/161400: Polycomb-Associated Non-Coding RNAs.
JD285772 - Sequence 266796 from Patent EP1572962.
AY147881 - Homo sapiens tissue-type testis chromosome 8 unknown mRNA.
JD561852 - Sequence 542876 from Patent EP1572962.
AK300583 - Homo sapiens cDNA FLJ50226 complete cds, moderately similar to Homo sapiens transmembrane protein 64 (TMEM64), mRNA.
JD194970 - Sequence 175994 from Patent EP1572962.
JD543705 - Sequence 524729 from Patent EP1572962.
LF353895 - JP 2014500723-A/161398: Polycomb-Associated Non-Coding RNAs.
KJ903957 - Synthetic construct Homo sapiens clone ccsbBroadEn_13351 TMEM64 gene, encodes complete protein.
LF353892 - JP 2014500723-A/161395: Polycomb-Associated Non-Coding RNAs.
LF353891 - JP 2014500723-A/161394: Polycomb-Associated Non-Coding RNAs.
LF353876 - JP 2014500723-A/161379: Polycomb-Associated Non-Coding RNAs.
LF353875 - JP 2014500723-A/161378: Polycomb-Associated Non-Coding RNAs.
JD485788 - Sequence 466812 from Patent EP1572962.
JD558085 - Sequence 539109 from Patent EP1572962.
JD513278 - Sequence 494302 from Patent EP1572962.
JD129704 - Sequence 110728 from Patent EP1572962.
JD129078 - Sequence 110102 from Patent EP1572962.
JD545890 - Sequence 526914 from Patent EP1572962.
JD164363 - Sequence 145387 from Patent EP1572962.
JD434573 - Sequence 415597 from Patent EP1572962.
LF353874 - JP 2014500723-A/161377: Polycomb-Associated Non-Coding RNAs.
MA589481 - JP 2018138019-A/161407: Polycomb-Associated Non-Coding RNAs.
MA589479 - JP 2018138019-A/161405: Polycomb-Associated Non-Coding RNAs.
MA589476 - JP 2018138019-A/161402: Polycomb-Associated Non-Coding RNAs.
MA589475 - JP 2018138019-A/161401: Polycomb-Associated Non-Coding RNAs.
MA589474 - JP 2018138019-A/161400: Polycomb-Associated Non-Coding RNAs.
MA589472 - JP 2018138019-A/161398: Polycomb-Associated Non-Coding RNAs.
MA589469 - JP 2018138019-A/161395: Polycomb-Associated Non-Coding RNAs.
MA589468 - JP 2018138019-A/161394: Polycomb-Associated Non-Coding RNAs.
MA589453 - JP 2018138019-A/161379: Polycomb-Associated Non-Coding RNAs.
MA589452 - JP 2018138019-A/161378: Polycomb-Associated Non-Coding RNAs.
MA589451 - JP 2018138019-A/161377: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001008495, NP_001008495, Q2HIZ7, Q6YI46, Q8N3G6, TMM64_HUMAN
UCSC ID: uc003yen.2
RefSeq Accession: NM_001008495
Protein: Q6YI46 (aka TMM64_HUMAN)
CCDS: CCDS34920.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001008495.3
exon count: 3CDS single in 3' UTR: no RNA size: 4819
ORF size: 1143CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2373.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.