Human Gene AGPAT1 (uc003oae.3) Description and Page Index
Description: Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1), transcript variant 1, mRNA. RefSeq Summary (NM_006411): This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:32,135,983-32,143,916 Size: 7,934 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr6:32,137,053-32,139,273 Size: 2,221 Coding Exon Count: 6
ID:PLCA_HUMAN DESCRIPTION: RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; EC=126.96.36.199; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 1; Short=1-AGP acyltransferase 1; Short=1-AGPAT 1; AltName: Full=Lysophosphatidic acid acyltransferase alpha; Short=LPAAT-alpha; AltName: Full=Protein G15; FUNCTION: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity). SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. SEQUENCE CAUTION: Sequence=AAB47493.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99943
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity GO:0005515 protein binding GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups
Biological Process: GO:0001819 positive regulation of cytokine production GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0006629 lipid metabolic process GO:0006644 phospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0008152 metabolic process GO:0008654 phospholipid biosynthetic process GO:0016024 CDP-diacylglycerol biosynthetic process GO:0031325 positive regulation of cellular metabolic process