Human Gene PRKD3 (uc002rqd.3) Description and Page Index
Description: Homo sapiens protein kinase D3 (PRKD3), mRNA. RefSeq Summary (NM_005813): This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB015982.2, SRR1660807.200070.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000234179.7/ ENSP00000234179.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr2:37,477,646-37,544,222 Size: 66,577 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr2:37,480,320-37,543,667 Size: 63,348 Coding Exon Count: 18
ID:KPCD3_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase D3; EC=126.96.36.199; AltName: Full=Protein kinase C nu type; AltName: Full=Protein kinase EPK2; AltName: Full=nPKC-nu; FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Activated by DAG and phorbol esters. Phorbol- ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. INTERACTION: P63027:VAMP2; NbExp=7; IntAct=EBI-1255366, EBI-520113; SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 2 phorbol-ester/DAG-type zinc fingers. SIMILARITY: Contains 1 protein kinase domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRKD3 CDC HuGE Published Literature: PRKD3 Positive Disease Associations: Bipolar Disorder Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94806
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.