Human Gene TYW3 (uc001dgn.3) Description and Page Index
Description: Homo sapiens tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) (TYW3), transcript variant 1, mRNA. RefSeq Summary (NM_138467): Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr1:75,198,836-75,232,360 Size: 33,525 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr1:75,198,929-75,229,797 Size: 30,869 Coding Exon Count: 6
ID:TYW3_HUMAN DESCRIPTION: RecName: Full=tRNA wybutosine-synthesizing protein 3 homolog; EC=2.1.1.-; AltName: Full=tRNA-yW-synthesizing protein 3; FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. SIMILARITY: Belongs to the TYW3 family. SEQUENCE CAUTION: Sequence=CAI46106.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6IPR3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.