Human Gene CXCL10 (uc003hjl.4) Description and Page Index
Description: Homo sapiens chemokine (C-X-C motif) ligand 10 (CXCL10), mRNA. RefSeq Summary (NM_001565): This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.136912.1, BC010954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306602.3/ ENSP00000305651.1 Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr4:76,942,269-76,944,689 Size: 2,421 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr4:76,943,083-76,944,584 Size: 1,502 Coding Exon Count: 4
ID:CXL10_HUMAN DESCRIPTION: RecName: Full=C-X-C motif chemokine 10; AltName: Full=10 kDa interferon gamma-induced protein; Short=Gamma-IP10; Short=IP-10; AltName: Full=Small-inducible cytokine B10; Contains: RecName: Full=CXCL10(1-73); Flags: Precursor; FUNCTION: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. SUBCELLULAR LOCATION: Secreted. INDUCTION: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response. PTM: CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes. MASS SPECTROMETRY: Mass=8641.8; Method=Electrospray; Range=22-98; Source=PubMed:11559369; SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL10 entry; URL="http://en.wikipedia.org/wiki/CXCL10";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CXCL10 CDC HuGE Published Literature: CXCL10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02778
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.