ID:SNX20_HUMAN DESCRIPTION: RecName: Full=Sorting nexin-20; AltName: Full=Selectin ligand-interactor cytoplasmic 1; FUNCTION: Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with no impact on leukocytes recruitment. SUBUNIT: Interacts with SELPLG. INTERACTION: Q14242:SELPLG; NbExp=5; IntAct=EBI-744896, EBI-1030190; SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Nucleus. Endosome. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes. SIMILARITY: Belongs to the sorting nexin family. SIMILARITY: Contains 1 PX (phox homology) domain.
Genetic Association Studies of Complex Diseases and Disorders
Inflammatory Bowel Diseases Richard H Duerr et al. Science (New York, N.Y.) 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene., Science (New York, N.Y.).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z614
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.