Human Gene GPR132 (uc001yqd.3) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 132 (GPR132), mRNA.
RefSeq Summary (NM_013345): This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Transcript (Including UTRs)
   Position: hg19 chr14:105,515,737-105,531,754 Size: 16,018 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr14:105,517,331-105,521,757 Size: 4,427 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:105,515,737-105,531,754)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 132; AltName: Full=G2 accumulation protein;
FUNCTION: Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Probable). Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).
TISSUE SPECIFICITY: Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
INDUCTION: By stress and DNA-damaging agents.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: Was originally (PubMed:11474113) thought to be a receptor for lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC), However, this work has been retracted.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GPR132
CDC HuGE Published Literature: GPR132

-  MalaCards Disease Associations
  MalaCards Gene Search: GPR132
Diseases sorted by gene-association score: lassa fever (6), inclusion conjunctivitis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.85 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 52.22 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -322.92899-0.359 Picture PostScript Text
3' UTR -758.101594-0.476 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR005388 - G2A_lysphc_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9UNW8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC068024 - Homo sapiens cDNA clone IMAGE:6187854, partial cds.
BC084546 - Homo sapiens G protein-coupled receptor 132, mRNA (cDNA clone MGC:99642 IMAGE:5455247), complete cds.
AX775935 - Sequence 205 from Patent WO03048202.
AX775841 - Sequence 111 from Patent WO03048202.
AX775939 - Sequence 209 from Patent WO03048202.
BC004555 - Homo sapiens G protein-coupled receptor 132, mRNA (cDNA clone IMAGE:4054377), partial cds.
AB465599 - Homo sapiens G2A mRNA for G protein-coupled receptor 132, variant 1, complete cds.
AB465600 - Homo sapiens G2A mRNA for G protein-coupled receptor 132, variant 2, complete cds.
JD152080 - Sequence 133104 from Patent EP1572962.
JD383786 - Sequence 364810 from Patent EP1572962.
JD266048 - Sequence 247072 from Patent EP1572962.
JD558253 - Sequence 539277 from Patent EP1572962.
JD564320 - Sequence 545344 from Patent EP1572962.
JD340993 - Sequence 322017 from Patent EP1572962.
JD138051 - Sequence 119075 from Patent EP1572962.
JD127695 - Sequence 108719 from Patent EP1572962.
JD167662 - Sequence 148686 from Patent EP1572962.
JD247067 - Sequence 228091 from Patent EP1572962.
JD247066 - Sequence 228090 from Patent EP1572962.
JD247068 - Sequence 228092 from Patent EP1572962.
JD413476 - Sequence 394500 from Patent EP1572962.
JD131536 - Sequence 112560 from Patent EP1572962.
JD198171 - Sequence 179195 from Patent EP1572962.
JD459836 - Sequence 440860 from Patent EP1572962.
JD212775 - Sequence 193799 from Patent EP1572962.
JD271429 - Sequence 252453 from Patent EP1572962.
JD536553 - Sequence 517577 from Patent EP1572962.
JD542802 - Sequence 523826 from Patent EP1572962.
JD231039 - Sequence 212063 from Patent EP1572962.
JD247065 - Sequence 228089 from Patent EP1572962.
JD425909 - Sequence 406933 from Patent EP1572962.
JD255779 - Sequence 236803 from Patent EP1572962.
JD550418 - Sequence 531442 from Patent EP1572962.
JD428444 - Sequence 409468 from Patent EP1572962.
JD153692 - Sequence 134716 from Patent EP1572962.
JD198635 - Sequence 179659 from Patent EP1572962.
JD272167 - Sequence 253191 from Patent EP1572962.
JD566438 - Sequence 547462 from Patent EP1572962.
JD129424 - Sequence 110448 from Patent EP1572962.
JD099596 - Sequence 80620 from Patent EP1572962.
JD399549 - Sequence 380573 from Patent EP1572962.
JD368072 - Sequence 349096 from Patent EP1572962.
JD247646 - Sequence 228670 from Patent EP1572962.
JD209018 - Sequence 190042 from Patent EP1572962.
JD303008 - Sequence 284032 from Patent EP1572962.
JD267927 - Sequence 248951 from Patent EP1572962.
JD481989 - Sequence 463013 from Patent EP1572962.
JD408739 - Sequence 389763 from Patent EP1572962.
JD068117 - Sequence 49141 from Patent EP1572962.
JD223629 - Sequence 204653 from Patent EP1572962.
JD379904 - Sequence 360928 from Patent EP1572962.
AK292142 - Homo sapiens cDNA FLJ75897 complete cds, highly similar to Homo sapiens G protein-coupled receptor 132 (GPR132), mRNA.
JD159775 - Sequence 140799 from Patent EP1572962.
AF083955 - Homo sapiens G protein-coupled receptor (G2A) mRNA, complete cds.
AX775937 - Sequence 207 from Patent WO03048202.
JD454438 - Sequence 435462 from Patent EP1572962.
JD475505 - Sequence 456529 from Patent EP1572962.
JD445672 - Sequence 426696 from Patent EP1572962.
JD114009 - Sequence 95033 from Patent EP1572962.
JD196663 - Sequence 177687 from Patent EP1572962.
JD225095 - Sequence 206119 from Patent EP1572962.
JD373899 - Sequence 354923 from Patent EP1572962.
JD277854 - Sequence 258878 from Patent EP1572962.
JD068382 - Sequence 49406 from Patent EP1572962.
JD347186 - Sequence 328210 from Patent EP1572962.
JD112849 - Sequence 93873 from Patent EP1572962.
JD555283 - Sequence 536307 from Patent EP1572962.
JD471367 - Sequence 452391 from Patent EP1572962.
JD480961 - Sequence 461985 from Patent EP1572962.
AK303654 - Homo sapiens cDNA FLJ56605 complete cds, highly similar to Probable G-protein coupled receptor 132.
JD159247 - Sequence 140271 from Patent EP1572962.
JD279605 - Sequence 260629 from Patent EP1572962.
JD065952 - Sequence 46976 from Patent EP1572962.
EU432121 - Homo sapiens G protein-coupled receptor 132 (GPR132) mRNA, complete cds.
EU543705 - Homo sapiens truncated G protein-coupled receptor 132 (GPR132) mRNA, complete cds.
BT007257 - Homo sapiens G protein-coupled receptor mRNA, complete cds.
KJ893715 - Synthetic construct Homo sapiens clone ccsbBroadEn_03109 GPR132 gene, encodes complete protein.
JD314326 - Sequence 295350 from Patent EP1572962.
JD530105 - Sequence 511129 from Patent EP1572962.
JD373309 - Sequence 354333 from Patent EP1572962.
JD492563 - Sequence 473587 from Patent EP1572962.
JD420298 - Sequence 401322 from Patent EP1572962.
JD041873 - Sequence 22897 from Patent EP1572962.
JD496570 - Sequence 477594 from Patent EP1572962.
JD437809 - Sequence 418833 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UNW8 (Reactome details) participates in the following event(s):

R-HSA-444731 GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-416476 G alpha (q) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: G2A, GP132_HUMAN, NM_013345, NP_037477, Q9BSU2, Q9UNW8
UCSC ID: uc001yqd.3
RefSeq Accession: NM_013345
Protein: Q9UNW8 (aka GP132_HUMAN)
CCDS: CCDS9997.1, CCDS61567.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_013345.2
exon count: 4CDS single in 3' UTR: no RNA size: 3652
ORF size: 1143CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1544.50frame shift in genome: no % Coverage: 99.56
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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