Human Gene THEM5 (uc021oyw.1) Description and Page Index
  Description: Homo sapiens thioesterase superfamily member 5 (THEM5), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:151,819,577-151,826,173 Size: 6,597 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr1:151,819,847-151,826,041 Size: 6,195 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:151,819,577-151,826,173)mRNA (may differ from genome)Protein (247 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ACO15_HUMAN
DESCRIPTION: RecName: Full=Acyl-coenzyme A thioesterase THEM5; EC=3.1.2.2; AltName: Full=Acyl-coenzyme A thioesterase 15; AltName: Full=Thioesterase superfamily member 5;
FUNCTION: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.
CATALYTIC ACTIVITY: Palmitoyl-CoA + H(2)O = CoA + palmitate.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.4 uM for palmitoyl-CoA (C16:0); KM=4.2 uM for stearoyl-CoA (C18:0); KM=2.9 uM for oleoyl-CoA (C18:1); KM=4.2 uM for linoleyl-CoA (C18:2);
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Mitochondrion matrix.
SIMILARITY: Belongs to the THEM4/THEM5 thioesterase family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): THEM5
CDC HuGE Published Literature: THEM5

-  MalaCards Disease Associations
  MalaCards Gene Search: THEM5
Diseases sorted by gene-association score: median rhomboid glossitis (2), geographic tongue (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 94.76 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 206.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.70132-0.316 Picture PostScript Text
3' UTR -79.28270-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006683 - Thioestr_supf

Pfam Domains:
PF03061 - Thioesterase superfamily

SCOP Domains:
54637 - Thioesterase/thiol ester dehydrase-isomerase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

4AE7
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q8N1Q8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0016787 hydrolase activity
GO:0047617 acyl-CoA hydrolase activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0035965 cardiolipin acyl-chain remodeling

Cellular Component:
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix


-  Descriptions from all associated GenBank mRNAs
  AK095283 - Homo sapiens cDNA FLJ37964 fis, clone CTONG2009766.
JD076231 - Sequence 57255 from Patent EP1572962.
JD460409 - Sequence 441433 from Patent EP1572962.
JD422662 - Sequence 403686 from Patent EP1572962.
JD255203 - Sequence 236227 from Patent EP1572962.
JD399741 - Sequence 380765 from Patent EP1572962.
JD397691 - Sequence 378715 from Patent EP1572962.
JD460214 - Sequence 441238 from Patent EP1572962.
JD536739 - Sequence 517763 from Patent EP1572962.
JD253663 - Sequence 234687 from Patent EP1572962.
JD442556 - Sequence 423580 from Patent EP1572962.
JD064965 - Sequence 45989 from Patent EP1572962.
JD442284 - Sequence 423308 from Patent EP1572962.
JD397692 - Sequence 378716 from Patent EP1572962.
JD422661 - Sequence 403685 from Patent EP1572962.
JD399740 - Sequence 380764 from Patent EP1572962.
JD399741 - Sequence 380765 from Patent EP1572962.
JD397691 - Sequence 378715 from Patent EP1572962.
JD536740 - Sequence 517764 from Patent EP1572962.
JD422661 - Sequence 403685 from Patent EP1572962.
JD399740 - Sequence 380764 from Patent EP1572962.
JD255203 - Sequence 236227 from Patent EP1572962.
JD399741 - Sequence 380765 from Patent EP1572962.
JD253663 - Sequence 234687 from Patent EP1572962.
JD397691 - Sequence 378715 from Patent EP1572962.
JD397692 - Sequence 378716 from Patent EP1572962.
BC101610 - Homo sapiens thioesterase superfamily member 5, mRNA (cDNA clone MGC:126659 IMAGE:8069116), complete cds.
BC112239 - Homo sapiens thioesterase superfamily member 5, mRNA (cDNA clone MGC:138444 IMAGE:8327707), complete cds.
JD061185 - Sequence 42209 from Patent EP1572962.
HQ258137 - Synthetic construct Homo sapiens clone IMAGE:100072446 thioesterase superfamily member 5 (THEM5) (THEM5) gene, encodes complete protein.
KJ895988 - Synthetic construct Homo sapiens clone ccsbBroadEn_05382 THEM5 gene, encodes complete protein.
JD188719 - Sequence 169743 from Patent EP1572962.
JD268788 - Sequence 249812 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N1Q8 (Reactome details) participates in the following event(s):

R-HSA-5690066 ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-8978868 Fatty acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ACO15_HUMAN, ACOT15, NM_182578, NP_872384, Q5T1C3, Q8N1Q8
UCSC ID: uc021oyw.1
RefSeq Accession: NM_182578
Protein: Q8N1Q8 (aka ACO15_HUMAN)
CCDS: CCDS1005.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182578.3
exon count: 6CDS single in 3' UTR: no RNA size: 1146
ORF size: 744CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 1232.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.