Human Gene GRHL3 (uc021oiw.1) Description and Page Index
Description: Homo sapiens grainyhead-like 3 (Drosophila) (GRHL3), transcript variant 3, mRNA. RefSeq Summary (NM_198174): This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010]. Transcript (Including UTRs) Position: hg19 chr1:24,645,812-24,690,970 Size: 45,159 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr1:24,646,042-24,690,861 Size: 44,820 Coding Exon Count: 16
ID:GRHL3_HUMAN DESCRIPTION: RecName: Full=Grainyhead-like protein 3 homolog; AltName: Full=Sister of mammalian grainyhead; AltName: Full=Transcription factor CP2-like 4; FUNCTION: May function as a transcription factor. SUBUNIT: Homodimer, also forms heterodimers with GRHL1 and GRHL2. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific. SIMILARITY: Belongs to the grh/CP2 family. Grainyhead subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TE85
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0005515 protein binding GO:0031490 chromatin DNA binding GO:0043565 sequence-specific DNA binding