Human Gene DAPL1 (uc002uaf.3) Description and Page Index
  Description: Homo sapiens death associated protein-like 1 (DAPL1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:159,651,829-159,672,496 Size: 20,668 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr2:159,651,885-159,672,333 Size: 20,449 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:159,651,829-159,672,496)mRNA (may differ from genome)Protein (107 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: DAPL1_HUMAN
DESCRIPTION: RecName: Full=Death-associated protein-like 1; AltName: Full=Early epithelial differentiation-associated protein;
FUNCTION: May play a role in the early stages of epithelial differentiation or in apoptosis (By similarity).
TISSUE SPECIFICITY: Expressed in hair follicle (at protein level).

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DAPL1
CDC HuGE Published Literature: DAPL1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 68.16 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 229.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.3056-0.309 Picture PostScript Text
3' UTR -37.42163-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024130 - DAP1/DAPL1

Pfam Domains:
PF15228 - Death-associated protein

ModBase Predicted Comparative 3D Structure on A0PJW8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0070513 death domain binding

Biological Process:
GO:0006915 apoptotic process
GO:0010507 negative regulation of autophagy
GO:0030154 cell differentiation
GO:0034198 cellular response to amino acid starvation
GO:0097190 apoptotic signaling pathway


-  Descriptions from all associated GenBank mRNAs
  AY324399 - Homo sapiens death-associated protein-like 1 mRNA, complete cds.
AF086541 - Homo sapiens full length insert cDNA clone ZE09G12.
BC140719 - Homo sapiens death associated protein-like 1, mRNA (cDNA clone MGC:176396 IMAGE:9021587), complete cds.
BC127682 - Homo sapiens death associated protein-like 1, mRNA (cDNA clone MGC:157769 IMAGE:40127452), complete cds.
BC127683 - Homo sapiens death associated protein-like 1, mRNA (cDNA clone MGC:157770 IMAGE:40127454), complete cds.
JD451625 - Sequence 432649 from Patent EP1572962.
HQ179938 - Homo sapiens isolate Ret_13 clone 13-77 death-associated protein-like 1 isoform 5 (DAPL1) mRNA, complete cds, alternatively spliced.
HQ179934 - Homo sapiens isolate Ret_14 clone 14-49 death-associated protein-like 1 isoform 1 (DAPL1) mRNA, complete cds, alternatively spliced.
HQ179935 - Homo sapiens isolate Ret_14 clone 14-10 death-associated protein-like 1 isoform 2 (DAPL1) mRNA, complete cds, alternatively spliced.
HQ179939 - Homo sapiens isolate Ret_14 clone 14-83 death-associated protein-like 1 isoform 6 (DAPL1) mRNA, complete cds, alternatively spliced.
HQ179936 - Homo sapiens isolate Ret_14 clone 14-39 death-associated protein-like 1 isoform 3 (DAPL1) mRNA, complete cds, alternatively spliced.
HQ179937 - Homo sapiens isolate Ret_14 clone 14-42 death-associated protein-like 1 isoform 4 (DAPL1) mRNA, complete cds, alternatively spliced.
KJ899937 - Synthetic construct Homo sapiens clone ccsbBroadEn_09331 DAPL1-like gene, encodes complete protein.
JD501958 - Sequence 482982 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0PJW8, A0PJW9, B9EIK6, DAPL1_HUMAN, EEDA, NM_001017920, NP_001017920
UCSC ID: uc002uaf.3
RefSeq Accession: NM_001017920
Protein: A0PJW8 (aka DAPL1_HUMAN)
CCDS: CCDS33307.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001017920.2
exon count: 4CDS single in 3' UTR: no RNA size: 551
ORF size: 324CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 848.00frame shift in genome: no % Coverage: 98.55
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.