Human Gene LGALS7 (uc002oje.3) Description and Page Index
  Description: Homo sapiens lectin, galactoside-binding, soluble, 7 (LGALS7), mRNA.
RefSeq Summary (NM_002307): The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP225960.1, CV575179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr19:39,261,608-39,264,157 Size: 2,550 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr19:39,261,666-39,264,132 Size: 2,467 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:39,261,608-39,264,157)mRNA (may differ from genome)Protein (136 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: LEG7_HUMAN
DESCRIPTION: RecName: Full=Galectin-7; Short=Gal-7; AltName: Full=HKL-14; AltName: Full=PI7; AltName: Full=p53-induced gene 1 protein;
FUNCTION: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted (Potential). Note=May be secreted by a non-classical secretory pathway.
TISSUE SPECIFICITY: Mainly expressed in stratified squamous epithelium.
INDUCTION: By p53/TP53.
SIMILARITY: Contains 1 galectin domain.
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Galectin-7; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00143";

-  MalaCards Disease Associations
  MalaCards Gene Search: LGALS7
Diseases sorted by gene-association score: postencephalitic parkinson disease (2), infantile neuroaxonal dystrophy 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 124.96 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 279.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7025-0.308 Picture PostScript Text
3' UTR -20.6058-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR001079 - Galectin_CRD

Pfam Domains:
PF00337 - Galactoside-binding lectin

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BKZ
- X-ray MuPIT

2GAL
- X-ray MuPIT

3GAL
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
3ZXE - X-ray MuPIT 3ZXF - X-ray MuPIT 4GAL - X-ray MuPIT
5GAL - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P47929
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030246 carbohydrate binding

Biological Process:
GO:0006915 apoptotic process
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC042911 - Homo sapiens lectin, galactoside-binding, soluble, 7B, mRNA (cDNA clone IMAGE:5479169), partial cds.
U06643 - Human keratinocyte lectin 14 (HKL-14) mRNA, complete cds.
BC073743 - Homo sapiens lectin, galactoside-binding, soluble, 7B, mRNA (cDNA clone MGC:88745 IMAGE:5478866), complete cds.
BC061588 - Homo sapiens lectin, galactoside-binding, soluble, 7B, mRNA (cDNA clone MGC:75149 IMAGE:6202380), complete cds.
L07769 - Homo sapiens galectin-7 mRNA, complete cds.
JD102661 - Sequence 83685 from Patent EP1572962.
KJ900799 - Synthetic construct Homo sapiens clone ccsbBroadEn_10193 LGALS7B gene, encodes complete protein.
AB590978 - Synthetic construct DNA, clone: pFN21AE1213, Homo sapiens LGALS7B gene for lectin, galactoside-binding, soluble, 7B, without stop codon, in Flexi system.
CR456917 - Homo sapiens full open reading frame cDNA clone RZPDo834E0716D for gene LGALS7, lectin, galactoside-binding, soluble, 7 (galectin 7); complete cds, incl. stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: LEG7_HUMAN, LGALS7B, NM_002307, NP_002298, P47929, PIG1, Q6IB87
UCSC ID: uc002oje.3
RefSeq Accession: NM_002307
Protein: P47929 (aka LEG7_HUMAN)
CCDS: CCDS33012.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002307.3
exon count: 4CDS single in 3' UTR: no RNA size: 515
ORF size: 411CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1010.00frame shift in genome: no % Coverage: 95.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.