Human Gene EPHX3 (uc002nap.3) Description and Page Index
  Description: Homo sapiens epoxide hydrolase 3 (EPHX3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:15,337,730-15,343,231 Size: 5,502 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr19:15,338,248-15,343,022 Size: 4,775 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:15,337,730-15,343,231)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Epoxide hydrolase 3; EC=3.3.-.-; AltName: Full=Abhydrolase domain-containing protein 9; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): EPHX3
CDC HuGE Published Literature: EPHX3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.60 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 174.95 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.30209-0.480 Picture PostScript Text
3' UTR -170.22518-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000073 - AB_hydrolase_1
IPR000639 - Epox_hydrolase-like

Pfam Domains:
PF00561 - alpha/beta hydrolase fold
PF12146 - Serine aminopeptidase, S33
PF12697 - Alpha/beta hydrolase family

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q9H6B9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004301 epoxide hydrolase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0097176 epoxide metabolic process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle

-  Descriptions from all associated GenBank mRNAs
  JD504521 - Sequence 485545 from Patent EP1572962.
AK026061 - Homo sapiens cDNA: FLJ22408 fis, clone HRC08416.
LF385183 - JP 2014500723-A/192686: Polycomb-Associated Non-Coding RNAs.
BC115002 - Homo sapiens abhydrolase domain containing 9, mRNA (cDNA clone MGC:131519 IMAGE:7482856), complete cds.
JD422917 - Sequence 403941 from Patent EP1572962.
JD136500 - Sequence 117524 from Patent EP1572962.
JD392867 - Sequence 373891 from Patent EP1572962.
JD306510 - Sequence 287534 from Patent EP1572962.
JD036934 - Sequence 17958 from Patent EP1572962.
JD164203 - Sequence 145227 from Patent EP1572962.
JD518831 - Sequence 499855 from Patent EP1572962.
BC132958 - Homo sapiens abhydrolase domain containing 9, mRNA (cDNA clone MGC:164589 IMAGE:40146980), complete cds.
BC132960 - Homo sapiens abhydrolase domain containing 9, mRNA (cDNA clone MGC:164591 IMAGE:40146982), complete cds.
JD193190 - Sequence 174214 from Patent EP1572962.
JD054223 - Sequence 35247 from Patent EP1572962.
JD378602 - Sequence 359626 from Patent EP1572962.
KJ894744 - Synthetic construct Homo sapiens clone ccsbBroadEn_04138 EPHX3 gene, encodes complete protein.
LF341049 - JP 2014500723-A/148552: Polycomb-Associated Non-Coding RNAs.
LF212705 - JP 2014500723-A/20208: Polycomb-Associated Non-Coding RNAs.
JD461862 - Sequence 442886 from Patent EP1572962.
JD140862 - Sequence 121886 from Patent EP1572962.
JD208961 - Sequence 189985 from Patent EP1572962.
JD547745 - Sequence 528769 from Patent EP1572962.
MA620760 - JP 2018138019-A/192686: Polycomb-Associated Non-Coding RNAs.
MA576626 - JP 2018138019-A/148552: Polycomb-Associated Non-Coding RNAs.
MA448282 - JP 2018138019-A/20208: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A3KMR3, ABHD9, EPHX3_HUMAN, NM_024794, NP_079070, Q9H6B9
UCSC ID: uc002nap.3
RefSeq Accession: NM_024794
Protein: Q9H6B9 (aka EPHX3_HUMAN)
CCDS: CCDS12327.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_024794.2
exon count: 7CDS single in 3' UTR: no RNA size: 1810
ORF size: 1083CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2128.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 164# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.