Human Gene SERPINB5 (uc002liz.4) Description and Page Index
  Description: Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 5 (SERPINB5), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr18:61,144,144-61,172,318 Size: 28,175 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr18:61,151,662-61,170,955 Size: 19,294 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:61,144,144-61,172,318)mRNA (may differ from genome)Protein (375 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: SPB5_HUMAN
DESCRIPTION: RecName: Full=Serpin B5; AltName: Full=Maspin; AltName: Full=Peptidase inhibitor 5; Short=PI-5;
FUNCTION: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
SUBUNIT: Interacts with IRF6.
SUBCELLULAR LOCATION: Secreted, extracellular space.
TISSUE SPECIFICITY: Normal mammary epithelial cells.
SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SerpinB5ID42267.html";

-  MalaCards Disease Associations
  MalaCards Gene Search: SERPINB5
Diseases sorted by gene-association score: syringoma (12), bone squamous cell carcinoma (11), mandibular cancer (11), pleomorphic adenoma (10), salivary gland cancer (9), jaw cancer (8), cheilitis (7), breast adenomyoepithelioma (7), breast myoepithelial neoplasm (7), polymorphous low-grade adenocarcinoma (6), lipoadenoma (6), mannosidosis, beta (5), breast cancer (5), pancreatic cancer (4), larynx cancer (4), gastric adenocarcinoma (3), prostate cancer (3), pancreatic ductal adenocarcinoma (3), ovarian cancer, somatic (2), lung cancer (2), colorectal cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 129.64 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 390.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.70142-0.329 Picture PostScript Text
3' UTR -366.121363-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023795 - Protease_inhib_I4_serpin_CS
IPR000240 - Serpin_B9/Maspin
IPR023796 - Serpin_dom
IPR000215 - Serpin_fam

Pfam Domains:
PF00079 - Serpin (serine protease inhibitor)

SCOP Domains:
56574 - Serpins

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1WZ9
- X-ray MuPIT

1XQG
- X-ray MuPIT

1XQJ
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1XU8 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P36952
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding

Biological Process:
GO:0002009 morphogenesis of an epithelium
GO:0010951 negative regulation of endopeptidase activity
GO:0030198 extracellular matrix organization
GO:0050678 regulation of epithelial cell proliferation
GO:0060512 prostate gland morphogenesis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK312765 - Homo sapiens cDNA, FLJ93175, highly similar to Homo sapiens serine (or cysteine) proteinase inhibitor, clade B(ovalbumin), member 5 (SERPINB5), mRNA.
BC020713 - Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 5, mRNA (cDNA clone MGC:22489 IMAGE:4248249), complete cds.
AK301667 - Homo sapiens cDNA FLJ57640 complete cds, highly similar to Serpin B5 precursor.
U04313 - Human maspin mRNA, complete cds.
CU676658 - Synthetic construct Homo sapiens gateway clone IMAGE:100021814 5' read SERPINB5 mRNA.
KJ901636 - Synthetic construct Homo sapiens clone ccsbBroadEn_11030 SERPINB5 gene, encodes complete protein.
KR711182 - Synthetic construct Homo sapiens clone CCSBHm_00021003 SERPINB5 (SERPINB5) mRNA, encodes complete protein.
BX640597 - Homo sapiens mRNA; cDNA DKFZp686G03223 (from clone DKFZp686G03223).
JD167519 - Sequence 148543 from Patent EP1572962.
JD486664 - Sequence 467688 from Patent EP1572962.
JD464173 - Sequence 445197 from Patent EP1572962.
JD051248 - Sequence 32272 from Patent EP1572962.
JD268777 - Sequence 249801 from Patent EP1572962.
JD347911 - Sequence 328935 from Patent EP1572962.
JD550407 - Sequence 531431 from Patent EP1572962.
JD495362 - Sequence 476386 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04115 - p53 signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6Y4, NM_002639, NP_002630, P36952, PI5, Q6N0B4, Q8WW89, SPB5_HUMAN
UCSC ID: uc002liz.4
RefSeq Accession: NM_002639
Protein: P36952 (aka SPB5_HUMAN)
CCDS: CCDS32839.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002639.4
exon count: 7CDS single in 3' UTR: no RNA size: 2633
ORF size: 1128CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 2456.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.