Human Gene SCGB2A2 (uc001ntc.3) Description and Page Index
  Description: Homo sapiens secretoglobin, family 2A, member 2 (SCGB2A2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:62,037,630-62,040,628 Size: 2,999 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr11:62,037,689-62,040,467 Size: 2,779 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:62,037,630-62,040,628)mRNA (may differ from genome)Protein (93 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SG2A2_HUMAN
DESCRIPTION: RecName: Full=Mammaglobin-A; AltName: Full=Mammaglobin-1; AltName: Full=Secretoglobin family 2A member 2; Flags: Precursor;
TISSUE SPECIFICITY: Mammary gland specific. Over-expressed in breast cancer.
SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SCGB2A2
CDC HuGE Published Literature: SCGB2A2
Positive Disease Associations: Macular Degeneration
Related Studies:
  1. Macular Degeneration
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: SCGB2A2
Diseases sorted by gene-association score: breast cancer (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 93.31 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 195.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.8059-0.166 Picture PostScript Text
3' UTR -28.16161-0.175 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003627 - Mamgb/prostatn
IPR016126 - Secretoglobin
IPR006039 - Uteroglobin-like_fam
IPR006038 - Uteroglobin-like_superfam

Pfam Domains:
PF01099 - Uteroglobin family

SCOP Domains:
48201 - Uteroglobin-like

ModBase Predicted Comparative 3D Structure on Q13296
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  JD438152 - Sequence 419176 from Patent EP1572962.
BC067220 - Homo sapiens secretoglobin, family 2A, member 2, mRNA (cDNA clone MGC:71974 IMAGE:30321681), complete cds.
U33147 - Human mammaglobin mRNA, complete cds.
BC128252 - Homo sapiens secretoglobin, family 2A, member 2, mRNA (cDNA clone MGC:149421 IMAGE:40115103), complete cds.
BC128402 - Homo sapiens secretoglobin, family 2A, member 2, mRNA (cDNA clone MGC:156166 IMAGE:40115099), complete cds.
KJ891613 - Synthetic construct Homo sapiens clone ccsbBroadEn_01007 SCGB2A2 gene, encodes complete protein.
KJ901572 - Synthetic construct Homo sapiens clone ccsbBroadEn_10966 SCGB2A2 gene, encodes complete protein.
AY217100 - Homo sapiens mammaglobin isoform mRNA, complete cds; alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A522, MGB1, NM_002411, NP_002402, Q13296, Q86WH8, SG2A2_HUMAN, UGB2
UCSC ID: uc001ntc.3
RefSeq Accession: NM_002411
Protein: Q13296 (aka SG2A2_HUMAN)
CCDS: CCDS8018.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002411.2
exon count: 3CDS single in 3' UTR: no RNA size: 502
ORF size: 282CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 537.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.