Human Gene ABHD10 (uc003dyk.5) Description and Page Index
  Description: Homo sapiens abhydrolase domain containing 10 (ABHD10), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.
RefSeq Summary (NM_018394): This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Transcript (Including UTRs)
   Position: hg19 chr3:111,697,723-111,712,215 Size: 14,493 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr3:111,697,909-111,710,568 Size: 12,660 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:111,697,723-111,712,215)mRNA (may differ from genome)Protein (306 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ABHDA_HUMAN
DESCRIPTION: RecName: Full=Mycophenolic acid acyl-glucuronide esterase, mitochondrial; EC=3.1.1.93; AltName: Full=Alpha/beta hydrolase domain-containing protein 10; Short=Abhydrolase domain-containing protein 10; Flags: Precursor;
FUNCTION: Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.
CATALYTIC ACTIVITY: Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronate.
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the AB hydrolase superfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ABHD10
CDC HuGE Published Literature: ABHD10

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.82 RPKM in Pituitary
Total median expression: 531.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.80186-0.397 Picture PostScript Text
3' UTR -417.091647-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00326 - Prolyl oligopeptidase family
PF00561 - alpha/beta hydrolase fold
PF12146 - Serine aminopeptidase, S33
PF12697 - Alpha/beta hydrolase family

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q9NUJ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
 Gene Details  Gene Details 
 Gene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
 Protein SequenceProtein Sequence Protein Sequence 
 AlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016787 hydrolase activity
GO:0102390 mycophenolic acid acyl-glucuronide esterase activity

Biological Process:
GO:0019391 glucuronoside catabolic process
GO:0052695 cellular glucuronidation

Cellular Component:
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK300018 - Homo sapiens cDNA FLJ50858 complete cds, highly similar to Homo sapiens abhydrolase domain containing 10 (ABHD10), mRNA.
BC014516 - Homo sapiens abhydrolase domain containing 10, mRNA (cDNA clone MGC:10276 IMAGE:3928510), complete cds.
AK093591 - Homo sapiens cDNA FLJ36272 fis, clone THYMU2003107.
AK002204 - Homo sapiens cDNA FLJ11342 fis, clone PLACE1010800.
AB528058 - Synthetic construct DNA, clone: pF1KE0174, Homo sapiens ABHD10 gene for abhydrolase domain containing protein 10, without stop codon, in Flexi system.
AM392560 - Synthetic construct Homo sapiens clone IMAGE:100002128 for hypothetical protein (ABHD10 gene).
KJ894193 - Synthetic construct Homo sapiens clone ccsbBroadEn_03587 ABHD10 gene, encodes complete protein.
AL713726 - Homo sapiens mRNA; cDNA DKFZp762K197 (from clone DKFZp762K197).
JD082764 - Sequence 63788 from Patent EP1572962.
JD410976 - Sequence 392000 from Patent EP1572962.
JD548772 - Sequence 529796 from Patent EP1572962.
JD371915 - Sequence 352939 from Patent EP1572962.
JD269883 - Sequence 250907 from Patent EP1572962.
JD357115 - Sequence 338139 from Patent EP1572962.
JD172410 - Sequence 153434 from Patent EP1572962.
JD046587 - Sequence 27611 from Patent EP1572962.
FW340065 - Screening.
JD323720 - Sequence 304744 from Patent EP1572962.
JD360783 - Sequence 341807 from Patent EP1572962.
JD020957 - Sequence 1981 from Patent EP1572962.
JD214440 - Sequence 195464 from Patent EP1572962.
JD077554 - Sequence 58578 from Patent EP1572962.
JD485736 - Sequence 466760 from Patent EP1572962.
JD030057 - Sequence 11081 from Patent EP1572962.
JD019173 - Sequence 197 from Patent EP1572962.
JD032164 - Sequence 13188 from Patent EP1572962.
JD481966 - Sequence 462990 from Patent EP1572962.
JD548907 - Sequence 529931 from Patent EP1572962.
JD439177 - Sequence 420201 from Patent EP1572962.
JD300364 - Sequence 281388 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NUJ1 (Reactome details) participates in the following event(s):

R-HSA-5694563 ABHD10 hydrolyses MPAG
R-HSA-156588 Glucuronidation
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-211859 Biological oxidations
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ABHDA_HUMAN, D3DN63, NM_018394, NP_060864, Q8TCF9, Q9NUJ1, uc003dyk.4
UCSC ID: uc003dyk.5
RefSeq Accession: NM_018394
Protein: Q9NUJ1 (aka ABHDA_HUMAN)
CCDS: CCDS2963.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_018394.3
exon count: 5CDS single in 3' UTR: no RNA size: 2771
ORF size: 921CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2006.00frame shift in genome: no % Coverage: 99.39
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.