Human Gene DESI1 (uc003bam.2) Description and Page Index
  Description: Homo sapiens desumoylating isopeptidase 1 (DESI1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:41,994,032-42,017,061 Size: 23,030 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr22:41,997,101-42,016,843 Size: 19,743 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr22:41,994,032-42,017,061)mRNA (may differ from genome)Protein (168 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Desumoylating isopeptidase 1; Short=DeSI-1; EC=3.4.-.-; AltName: Full=PPPDE peptidase domain-containing protein 2; AltName: Full=Protein FAM152B;
FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
SIMILARITY: Belongs to the DeSI family.
SIMILARITY: Contains 1 PPPDE peptidase domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.96 RPKM in Testis
Total median expression: 603.19 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -95.00218-0.436 Picture PostScript Text
3' UTR -1374.013069-0.448 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008580 - DUF862_euk

Pfam Domains:
PF05903 - PPPDE putative peptidase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q6ICB0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding

Biological Process:
GO:0006508 proteolysis

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC039554 - Homo sapiens cDNA clone IMAGE:3878236, partial cds.
BC008357 - Homo sapiens, clone IMAGE:3605655, mRNA.
AK090725 - Homo sapiens cDNA FLJ33406 fis, clone BRACE2010477.
JD019149 - Sequence 173 from Patent EP1572962.
JD034516 - Sequence 15540 from Patent EP1572962.
JD030442 - Sequence 11466 from Patent EP1572962.
JD533681 - Sequence 514705 from Patent EP1572962.
JD421882 - Sequence 402906 from Patent EP1572962.
JD421881 - Sequence 402905 from Patent EP1572962.
JD254742 - Sequence 235766 from Patent EP1572962.
JD285592 - Sequence 266616 from Patent EP1572962.
JD072378 - Sequence 53402 from Patent EP1572962.
JD072377 - Sequence 53401 from Patent EP1572962.
JD225391 - Sequence 206415 from Patent EP1572962.
JD345718 - Sequence 326742 from Patent EP1572962.
JD068506 - Sequence 49530 from Patent EP1572962.
JD187702 - Sequence 168726 from Patent EP1572962.
JD489242 - Sequence 470266 from Patent EP1572962.
JD409308 - Sequence 390332 from Patent EP1572962.
JD228833 - Sequence 209857 from Patent EP1572962.
JD207106 - Sequence 188130 from Patent EP1572962.
JD175126 - Sequence 156150 from Patent EP1572962.
LF337434 - JP 2014500723-A/144937: Polycomb-Associated Non-Coding RNAs.
JD269335 - Sequence 250359 from Patent EP1572962.
JD333033 - Sequence 314057 from Patent EP1572962.
JD040152 - Sequence 21176 from Patent EP1572962.
LF337435 - JP 2014500723-A/144938: Polycomb-Associated Non-Coding RNAs.
JD413259 - Sequence 394283 from Patent EP1572962.
JD529956 - Sequence 510980 from Patent EP1572962.
JD362849 - Sequence 343873 from Patent EP1572962.
AF038183 - Homo sapiens clone 23674 mRNA sequence.
CR456458 - Homo sapiens dJ347H13.4 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ347H13.4).
JD306076 - Sequence 287100 from Patent EP1572962.
JD301314 - Sequence 282338 from Patent EP1572962.
JD433491 - Sequence 414515 from Patent EP1572962.
LF337436 - JP 2014500723-A/144939: Polycomb-Associated Non-Coding RNAs.
BC093956 - Homo sapiens PPPDE peptidase domain containing 2, mRNA (cDNA clone MGC:120991 IMAGE:7939801), complete cds.
BC112179 - Homo sapiens PPPDE peptidase domain containing 2, mRNA (cDNA clone MGC:138384 IMAGE:8327647), complete cds.
JD060097 - Sequence 41121 from Patent EP1572962.
BC171724 - Homo sapiens cDNA clone IMAGE:9051883.
JD380301 - Sequence 361325 from Patent EP1572962.
CU013008 - Homo sapiens dJ347H13.4, mRNA (cDNA clone IMAGE:100000171), complete cds, with stop codon, in Gateway system.
AB528118 - Synthetic construct DNA, clone: pF1KE0508, Homo sapiens FAM152B gene for PPPDE peptidase domain containing 2, without stop codon, in Flexi system.
CU013296 - Homo sapiens dJ347H13.4, mRNA (cDNA clone IMAGE:100000075), complete cds, without stop codon, in Gateway system.
LF337438 - JP 2014500723-A/144941: Polycomb-Associated Non-Coding RNAs.
JD144330 - Sequence 125354 from Patent EP1572962.
JD108748 - Sequence 89772 from Patent EP1572962.
JD478301 - Sequence 459325 from Patent EP1572962.
MA573011 - JP 2018138019-A/144937: Polycomb-Associated Non-Coding RNAs.
MA573012 - JP 2018138019-A/144938: Polycomb-Associated Non-Coding RNAs.
MA573013 - JP 2018138019-A/144939: Polycomb-Associated Non-Coding RNAs.
MA573015 - JP 2018138019-A/144941: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DESI1_HUMAN, FAM152B, NM_015704, NP_056519, PPPDE2, Q6ICB0
UCSC ID: uc003bam.2
RefSeq Accession: NM_015704
Protein: Q6ICB0 (aka DESI1_HUMAN)
CCDS: CCDS33652.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_015704.2
exon count: 6CDS single in 3' UTR: no RNA size: 3804
ORF size: 507CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1214.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.