Human Gene DESI1 (uc003bam.2) Description and Page Index
Description: Homo sapiens desumoylating isopeptidase 1 (DESI1), mRNA.
Transcript (Including UTRs)
Position: hg19 chr22:41,994,032-42,017,061 Size: 23,030 Total Exon Count: 6 Strand: -
Position: hg19 chr22:41,997,101-42,016,843 Size: 19,743 Coding Exon Count: 6
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Desumoylating isopeptidase 1; Short=DeSI-1; EC=3.4.-.-; AltName: Full=PPPDE peptidase domain-containing protein 2; AltName: Full=Protein FAM152B;
FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the DeSI family. SIMILARITY: Contains 1 PPPDE peptidase domain.
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR008580 - DUF862_euk
Pfam Domains: PF05903 - PPPDE putative peptidase domain
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q6ICB0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC039554 - Homo sapiens cDNA clone IMAGE:3878236, partial cds. BC008357 - Homo sapiens, clone IMAGE:3605655, mRNA. AK090725 - Homo sapiens cDNA FLJ33406 fis, clone BRACE2010477. JD019149 - Sequence 173 from Patent EP1572962. JD034516 - Sequence 15540 from Patent EP1572962. JD030442 - Sequence 11466 from Patent EP1572962. JD533681 - Sequence 514705 from Patent EP1572962. JD421882 - Sequence 402906 from Patent EP1572962. JD421881 - Sequence 402905 from Patent EP1572962. JD254742 - Sequence 235766 from Patent EP1572962. JD285592 - Sequence 266616 from Patent EP1572962. JD072378 - Sequence 53402 from Patent EP1572962. JD072377 - Sequence 53401 from Patent EP1572962. JD225391 - Sequence 206415 from Patent EP1572962. JD345718 - Sequence 326742 from Patent EP1572962. JD068506 - Sequence 49530 from Patent EP1572962. JD187702 - Sequence 168726 from Patent EP1572962. JD489242 - Sequence 470266 from Patent EP1572962. JD409308 - Sequence 390332 from Patent EP1572962. JD228833 - Sequence 209857 from Patent EP1572962. JD207106 - Sequence 188130 from Patent EP1572962. JD175126 - Sequence 156150 from Patent EP1572962. LF337434 - JP 2014500723-A/144937: Polycomb-Associated Non-Coding RNAs. JD269335 - Sequence 250359 from Patent EP1572962. JD333033 - Sequence 314057 from Patent EP1572962. JD040152 - Sequence 21176 from Patent EP1572962. LF337435 - JP 2014500723-A/144938: Polycomb-Associated Non-Coding RNAs. JD413259 - Sequence 394283 from Patent EP1572962. JD529956 - Sequence 510980 from Patent EP1572962. JD362849 - Sequence 343873 from Patent EP1572962. AF038183 - Homo sapiens clone 23674 mRNA sequence. CR456458 - Homo sapiens dJ347H13.4 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ347H13.4). JD306076 - Sequence 287100 from Patent EP1572962. JD301314 - Sequence 282338 from Patent EP1572962. JD433491 - Sequence 414515 from Patent EP1572962. LF337436 - JP 2014500723-A/144939: Polycomb-Associated Non-Coding RNAs. BC093956 - Homo sapiens PPPDE peptidase domain containing 2, mRNA (cDNA clone MGC:120991 IMAGE:7939801), complete cds. BC112179 - Homo sapiens PPPDE peptidase domain containing 2, mRNA (cDNA clone MGC:138384 IMAGE:8327647), complete cds. JD060097 - Sequence 41121 from Patent EP1572962. BC171724 - Homo sapiens cDNA clone IMAGE:9051883. JD380301 - Sequence 361325 from Patent EP1572962. CU013008 - Homo sapiens dJ347H13.4, mRNA (cDNA clone IMAGE:100000171), complete cds, with stop codon, in Gateway system. AB528118 - Synthetic construct DNA, clone: pF1KE0508, Homo sapiens FAM152B gene for PPPDE peptidase domain containing 2, without stop codon, in Flexi system. CU013296 - Homo sapiens dJ347H13.4, mRNA (cDNA clone IMAGE:100000075), complete cds, without stop codon, in Gateway system. LF337438 - JP 2014500723-A/144941: Polycomb-Associated Non-Coding RNAs. JD144330 - Sequence 125354 from Patent EP1572962. JD108748 - Sequence 89772 from Patent EP1572962. JD478301 - Sequence 459325 from Patent EP1572962. MA573011 - JP 2018138019-A/144937: Polycomb-Associated Non-Coding RNAs. MA573012 - JP 2018138019-A/144938: Polycomb-Associated Non-Coding RNAs. MA573013 - JP 2018138019-A/144939: Polycomb-Associated Non-Coding RNAs. MA573015 - JP 2018138019-A/144941: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: DESI1_HUMAN, FAM152B, NM_015704, NP_056519, PPPDE2, Q6ICB0 UCSC ID: uc003bam.2 RefSeq Accession: NM_015704
(aka DESI1_HUMAN) Q6ICB0
Gene Model Information
6 CDS single in 3' UTR:
507 CDS single in intron:
Alignment % ID:
1214.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.