Human Gene ELOF1 (uc002mse.1) Description and Page Index
  Description: Homo sapiens elongation factor 1 homolog (S. cerevisiae) (ELOF1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:11,663,858-11,670,051 Size: 6,194 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr19:11,664,561-11,665,162 Size: 602 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:11,663,858-11,670,051)mRNA (may differ from genome)Protein (83 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transcription elongation factor 1 homolog;
FUNCTION: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the ELOF1 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ELOF1
CDC HuGE Published Literature: ELOF1
Positive Disease Associations: Multiple Sclerosis
Related Studies:
  1. Multiple Sclerosis
    Sergio E Baranzini et al. Human molecular genetics 2009, Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis., Human molecular genetics. [PubMed 19010793]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.62 RPKM in Testis
Total median expression: 466.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.8064-0.325 Picture PostScript Text
3' UTR -299.34703-0.426 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007808 - DUF701_Zn-bd

Pfam Domains:
PF05129 - Transcription elongation factor Elf1 like

ModBase Predicted Comparative 3D Structure on P60002
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000993 RNA polymerase II core binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0048096 chromatin-mediated maintenance of transcription

Cellular Component:
GO:0005634 nucleus
GO:0008023 transcription elongation factor complex

-  Descriptions from all associated GenBank mRNAs
  AK097850 - Homo sapiens cDNA FLJ40531 fis, clone TESTI2047792.
LF384528 - JP 2014500723-A/192031: Polycomb-Associated Non-Coding RNAs.
AK001171 - Homo sapiens cDNA FLJ10309 fis, clone NT2RM2000287.
MA620105 - JP 2018138019-A/192031: Polycomb-Associated Non-Coding RNAs.
HQ447926 - Synthetic construct Homo sapiens clone IMAGE:100071285; CCSB004754_01 elongation factor 1 homolog (S. cerevisiae) (ELOF1) gene, encodes complete protein.
KJ894991 - Synthetic construct Homo sapiens clone ccsbBroadEn_04385 ELOF1 gene, encodes complete protein.
BC007516 - Homo sapiens elongation factor 1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4549 IMAGE:3028469), complete cds.
LF375847 - JP 2014500723-A/183350: Polycomb-Associated Non-Coding RNAs.
JD408783 - Sequence 389807 from Patent EP1572962.
JD146504 - Sequence 127528 from Patent EP1572962.
JD151427 - Sequence 132451 from Patent EP1572962.
JD204242 - Sequence 185266 from Patent EP1572962.
LF211108 - JP 2014500723-A/18611: Polycomb-Associated Non-Coding RNAs.
JD412980 - Sequence 394004 from Patent EP1572962.
JD283157 - Sequence 264181 from Patent EP1572962.
JD347595 - Sequence 328619 from Patent EP1572962.
LF375848 - JP 2014500723-A/183351: Polycomb-Associated Non-Coding RNAs.
JD078136 - Sequence 59160 from Patent EP1572962.
JD109126 - Sequence 90150 from Patent EP1572962.
LF344021 - JP 2014500723-A/151524: Polycomb-Associated Non-Coding RNAs.
JD104544 - Sequence 85568 from Patent EP1572962.
EU832623 - Synthetic construct Homo sapiens clone HAIB:100067652; DKFZo008B1131 elongation factor 1 homolog (S. cerevisiae) protein (ELOF1) gene, encodes complete protein.
EU832696 - Synthetic construct Homo sapiens clone HAIB:100067725; DKFZo004B1132 elongation factor 1 homolog (S. cerevisiae) protein (ELOF1) gene, encodes complete protein.
MA579598 - JP 2018138019-A/151524: Polycomb-Associated Non-Coding RNAs.
MA611424 - JP 2018138019-A/183350: Polycomb-Associated Non-Coding RNAs.
MA446685 - JP 2018138019-A/18611: Polycomb-Associated Non-Coding RNAs.
MA611425 - JP 2018138019-A/183351: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ELOF1_HUMAN, NM_032377, NP_115753, P60002, Q8R1J7, Q96II4
UCSC ID: uc002mse.1
RefSeq Accession: NM_032377
Protein: P60002 (aka ELOF1_HUMAN)
CCDS: CCDS12264.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032377.3
exon count: 4CDS single in 3' UTR: no RNA size: 1029
ORF size: 252CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 704.00frame shift in genome: no % Coverage: 99.03
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.