Human Gene ZNHIT3 (uc002hms.1) Description and Page Index
  Description: Homo sapiens zinc finger, HIT-type containing 3 (ZNHIT3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:34,842,473-34,851,662 Size: 9,190 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr17:34,842,544-34,851,248 Size: 8,705 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:34,842,473-34,851,662)mRNA (may differ from genome)Protein (155 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger HIT domain-containing protein 3; AltName: Full=HNF-4a coactivator; AltName: Full=Thyroid hormone receptor interactor 3; AltName: Full=Thyroid receptor-interacting protein 3; Short=TR-interacting protein 3; Short=TRIP-3;
SUBUNIT: Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
SIMILARITY: Contains 1 HIT-type zinc finger.

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNHIT3
Diseases sorted by gene-association score: peho syndrome* (1250), chromosome 17q12 deletion syndrome (7)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.9071-0.407 Picture PostScript Text
3' UTR -120.09414-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007529 - Znf_HIT

Pfam Domains:
PF04438 - HIT zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help


ModBase Predicted Comparative 3D Structure on Q15649
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046966 thyroid hormone receptor binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  LF384782 - JP 2014500723-A/192285: Polycomb-Associated Non-Coding RNAs.
AF400652 - Homo sapiens thyroid hormone receptor interacting protein 3 mRNA, complete cds.
BC105608 - Homo sapiens cDNA clone IMAGE:6715876.
BC017931 - Homo sapiens zinc finger, HIT type 3, mRNA (cDNA clone MGC:23962 IMAGE:4669658), complete cds.
AK290858 - Homo sapiens cDNA FLJ76553 complete cds, highly similar to Homo sapiens thyroid hormone receptor interactor 3 (TRIP3), mRNA.
JD040301 - Sequence 21325 from Patent EP1572962.
AK096494 - Homo sapiens cDNA FLJ39175 fis, clone OCBBF2003593.
AK310022 - Homo sapiens cDNA, FLJ17064.
KJ892746 - Synthetic construct Homo sapiens clone ccsbBroadEn_02140 ZNHIT3 gene, encodes complete protein.
AB464422 - Synthetic construct DNA, clone: pF1KB7527, Homo sapiens ZNHIT3 gene for zinc finger, HIT protein type 3, without stop codon, in Flexi system.
AK308583 - Homo sapiens cDNA, FLJ98624.
L40410 - Homo sapiens thyroid receptor interactor (TRIP3) mRNA, 3' end of cds.
DQ571862 - Homo sapiens piRNA piR-31974, complete sequence.
AB209193 - Homo sapiens mRNA for thyroid hormone receptor interactor 3 variant protein.
LF327066 - JP 2014500723-A/134569: Polycomb-Associated Non-Coding RNAs.
DQ592775 - Homo sapiens piRNA piR-59887, complete sequence.
JD183449 - Sequence 164473 from Patent EP1572962.
JD231425 - Sequence 212449 from Patent EP1572962.
JD424726 - Sequence 405750 from Patent EP1572962.
JD539187 - Sequence 520211 from Patent EP1572962.
JD416658 - Sequence 397682 from Patent EP1572962.
JD337353 - Sequence 318377 from Patent EP1572962.
JD484022 - Sequence 465046 from Patent EP1572962.
JD302112 - Sequence 283136 from Patent EP1572962.
JD103544 - Sequence 84568 from Patent EP1572962.
JD109931 - Sequence 90955 from Patent EP1572962.
MA620359 - JP 2018138019-A/192285: Polycomb-Associated Non-Coding RNAs.
MA562643 - JP 2018138019-A/134569: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K493, NM_004773, NP_004764, Q15649, Q8WVJ3, TRIP3, ZNHI3_HUMAN
UCSC ID: uc002hms.1
RefSeq Accession: NM_004773
Protein: Q15649 (aka ZNHI3_HUMAN)
CCDS: CCDS11312.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_004773.2
exon count: 5CDS single in 3' UTR: no RNA size: 983
ORF size: 468CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1136.00frame shift in genome: no % Coverage: 96.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.