Human Gene HIRIP3 (uc002dve.3) Description and Page Index
Description: Homo sapiens HIRA interacting protein 3 (HIRIP3), transcript variant 1, mRNA. RefSeq Summary (NM_003609): The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr16:30,003,642-30,007,417 Size: 3,776 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr16:30,004,528-30,006,926 Size: 2,399 Coding Exon Count: 7
ID:HIRP3_HUMAN DESCRIPTION: RecName: Full=HIRA-interacting protein 3; FUNCTION: May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. SUBUNIT: Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2. SUBCELLULAR LOCATION: Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis. TISSUE SPECIFICITY: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart. PTM: Phosphorylated by CK2.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): HIRIP3 CDC HuGE Published Literature: HIRIP3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BW71
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.