Human Gene HIRIP3 (uc002dve.3) Description and Page Index
  Description: Homo sapiens HIRA interacting protein 3 (HIRIP3), transcript variant 1, mRNA.
RefSeq Summary (NM_003609): The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
Transcript (Including UTRs)
   Position: hg19 chr16:30,003,642-30,007,417 Size: 3,776 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr16:30,004,528-30,006,926 Size: 2,399 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:30,003,642-30,007,417)mRNA (may differ from genome)Protein (556 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=HIRA-interacting protein 3;
FUNCTION: May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
SUBUNIT: Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2.
SUBCELLULAR LOCATION: Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
TISSUE SPECIFICITY: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.
PTM: Phosphorylated by CK2.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): HIRIP3
CDC HuGE Published Literature: HIRIP3

-  MalaCards Disease Associations
  MalaCards Gene Search: HIRIP3
Diseases sorted by gene-association score: velocardiofacial syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.91 RPKM in Testis
Total median expression: 495.39 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -185.14491-0.377 Picture PostScript Text
3' UTR -300.11886-0.339 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019098 - Histone_chaperone_domain_CHZ

Pfam Domains:
PF09649 - Histone chaperone domain CHZ

ModBase Predicted Comparative 3D Structure on Q9BW71
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006333 chromatin assembly or disassembly

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus

-  Descriptions from all associated GenBank mRNAs
  JD324156 - Sequence 305180 from Patent EP1572962.
AJ223350 - Homo sapiens mRNA for HIRIP3 protein, clone pH4-17.
AJ223349 - Homo sapiens mRNA for HIRIP3 protein, clone pH4-31.
AJ223351 - Homo sapiens mRNA for HIRIP3 protein (clone pH4-31, pH4-17).
BC000588 - Homo sapiens HIRA interacting protein 3, mRNA (cDNA clone MGC:1814 IMAGE:3345739), complete cds.
AK075145 - Homo sapiens cDNA FLJ90664 fis, clone PLACE1005239, highly similar to HIRA-interacting protein 3.
JD025165 - Sequence 6189 from Patent EP1572962.
JD029983 - Sequence 11007 from Patent EP1572962.
JD034407 - Sequence 15431 from Patent EP1572962.
JD507974 - Sequence 488998 from Patent EP1572962.
JD373302 - Sequence 354326 from Patent EP1572962.
AK312504 - Homo sapiens cDNA, FLJ92868, highly similar to Homo sapiens HIRA interacting protein 3 (HIRIP3), mRNA.
JF432481 - Synthetic construct Homo sapiens clone IMAGE:100073702 HIRA interacting protein 3 (HIRIP3) gene, encodes complete protein.
KJ892541 - Synthetic construct Homo sapiens clone ccsbBroadEn_01935 HIRIP3 gene, encodes complete protein.
DQ576885 - Homo sapiens piRNA piR-44997, complete sequence.
JD187482 - Sequence 168506 from Patent EP1572962.
DQ585224 - Homo sapiens piRNA piR-52336, complete sequence.
DQ585175 - Homo sapiens piRNA piR-52287, complete sequence.
JD406591 - Sequence 387615 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: HIRP3_HUMAN, NM_003609, NP_003600, O75707, O75708, Q9BW71
UCSC ID: uc002dve.3
RefSeq Accession: NM_003609
Protein: Q9BW71 (aka HIRP3_HUMAN or HIR3_HUMAN)
CCDS: CCDS10664.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003609.4
exon count: 7CDS single in 3' UTR: no RNA size: 3065
ORF size: 1671CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3425.00frame shift in genome: no % Coverage: 99.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.