Human Gene PTDSS2 (uc001lpj.3) Description and Page Index
Description: Homo sapiens phosphatidylserine synthase 2 (PTDSS2), mRNA. RefSeq Summary (NM_030783): The protein encoded by this gene catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine, a structural membrane phospholipid that functions in cell signaling, blood coagulation, and apoptosis. The encoded enzyme also has a high affinity for docosahexaenoic acid (DHA) and can use it to make DHA-containing phosphatidylserine. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr11:450,280-491,387 Size: 41,108 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr11:450,456-490,582 Size: 40,127 Coding Exon Count: 12
ID:PTSS2_HUMAN DESCRIPTION: RecName: Full=Phosphatidylserine synthase 2; Short=PSS-2; Short=PtdSer synthase 2; EC=22.214.171.124; AltName: Full=Serine-exchange enzyme II; FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine. CATALYTIC ACTIVITY: L-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine. ENZYME REGULATION: Inhibited in both the MAM and the ER per se by ethanolamine. Requires calcium ions. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=120 uM for serine (in the presence of 1 mM PE); Vmax=0.57 mmol/h/mg enzyme; pH dependence: Optimum pH is around 7.5; PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Highly enriched in the mitochondria-associated membrane (MAM) (By similarity). SIMILARITY: Belongs to the phosphatidyl serine synthase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BVG9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.