Human Gene CYTH1 (uc002jvw.3) Description and Page Index
  Description: Homo sapiens cytohesin 1 (CYTH1), transcript variant 2, mRNA.
RefSeq Summary (NM_017456): The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Transcript (Including UTRs)
   Position: hg19 chr17:76,670,130-76,778,376 Size: 108,247 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr17:76,672,173-76,778,305 Size: 106,133 Coding Exon Count: 13 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:76,670,130-76,778,376)mRNA (may differ from genome)Protein (397 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: CYTH1
Diseases sorted by gene-association score: heterotopia, periventricular (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 66.14 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 881.41 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.6071-0.642 Picture PostScript Text
3' UTR -878.512043-0.430 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00169 - PH domain
PF01369 - Sec7 domain

SCOP Domains:
48425 - Sec7 domain
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q15438-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 Protein SequenceProtein SequenceProtein Sequence  

-  Descriptions from all associated GenBank mRNAs
  BC038385 - Homo sapiens cytohesin 1, mRNA (cDNA clone MGC:21351 IMAGE:4755203), complete cds.
M85169 - Human homologue of yeast sec7 mRNA, complete cds.
BC050452 - Homo sapiens cytohesin 1, mRNA (cDNA clone MGC:54241 IMAGE:6043039), complete cds.
AK293894 - Homo sapiens cDNA FLJ54415 complete cds, highly similar to Cytohesin-1.
AK316277 - Homo sapiens cDNA, FLJ79176 complete cds, highly similar to Cytohesin-1.
AK316075 - Homo sapiens cDNA, FLJ78974 complete cds, highly similar to Cytohesin-1.
AK307917 - Homo sapiens cDNA, FLJ97865.
AK296914 - Homo sapiens cDNA FLJ59923 complete cds, highly similar to Cytohesin-1.
EU832306 - Synthetic construct Homo sapiens clone HAIB:100067335; DKFZo008C0927 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) protein (PSCD1) gene, encodes complete protein.
EU832390 - Synthetic construct Homo sapiens clone HAIB:100067419; DKFZo004C0928 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) protein (PSCD1) gene, encodes complete protein.
AB590939 - Synthetic construct DNA, clone: pFN21AE1139, Homo sapiens CYTH1 gene for cytohesin 1, without stop codon, in Flexi system.
AK123894 - Homo sapiens cDNA FLJ41900 fis, clone OCBBF3000483.
AF054997 - Homo sapiens clone 23796 mRNA sequence.
AK091369 - Homo sapiens cDNA FLJ34050 fis, clone FCBBF3000115.
AX746941 - Sequence 466 from Patent EP1308459.
AL832791 - Homo sapiens mRNA; cDNA DKFZp667F0323 (from clone DKFZp667F0323).
JD438334 - Sequence 419358 from Patent EP1572962.
JD527186 - Sequence 508210 from Patent EP1572962.
JD062300 - Sequence 43324 from Patent EP1572962.
JD280601 - Sequence 261625 from Patent EP1572962.
JD051648 - Sequence 32672 from Patent EP1572962.
JD347320 - Sequence 328344 from Patent EP1572962.
JD535883 - Sequence 516907 from Patent EP1572962.
JD372726 - Sequence 353750 from Patent EP1572962.
JD191221 - Sequence 172245 from Patent EP1572962.
JD384988 - Sequence 366012 from Patent EP1572962.
JD524865 - Sequence 505889 from Patent EP1572962.
JD129895 - Sequence 110919 from Patent EP1572962.
JD100346 - Sequence 81370 from Patent EP1572962.
JD462133 - Sequence 443157 from Patent EP1572962.
JD392648 - Sequence 373672 from Patent EP1572962.
JD253647 - Sequence 234671 from Patent EP1572962.
JD395824 - Sequence 376848 from Patent EP1572962.
JD261002 - Sequence 242026 from Patent EP1572962.
JD360064 - Sequence 341088 from Patent EP1572962.
JD334083 - Sequence 315107 from Patent EP1572962.
JD303996 - Sequence 285020 from Patent EP1572962.
JD205776 - Sequence 186800 from Patent EP1572962.
JD251442 - Sequence 232466 from Patent EP1572962.
JD203535 - Sequence 184559 from Patent EP1572962.
JD177949 - Sequence 158973 from Patent EP1572962.
JD464948 - Sequence 445972 from Patent EP1572962.
JD338204 - Sequence 319228 from Patent EP1572962.
JD462455 - Sequence 443479 from Patent EP1572962.
JD108588 - Sequence 89612 from Patent EP1572962.
JD164043 - Sequence 145067 from Patent EP1572962.
JD078069 - Sequence 59093 from Patent EP1572962.
JD562919 - Sequence 543943 from Patent EP1572962.
JD198709 - Sequence 179733 from Patent EP1572962.
JD423277 - Sequence 404301 from Patent EP1572962.
JD170809 - Sequence 151833 from Patent EP1572962.
AK311535 - Homo sapiens cDNA, FLJ18577.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_arapPathway - ADP-Ribosylation Factor

Reactome (by CSHL, EBI, and GO)

Protein Q15438 (Reactome details) participates in the following event(s):

R-HSA-8847880 CYTH proteins bind ARF1:GTP
R-HSA-8847883 CYTH proteins stimulate ARF1 GTPase activity
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: D17S811E, NM_017456, NP_059430, PSCD1, Q15438-2
UCSC ID: uc002jvw.3
RefSeq Accession: NM_017456
Protein: Q15438-2, splice isoform of Q15438 CCDS: CCDS32754.1, CCDS42392.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_017456.2
exon count: 13CDS single in 3' UTR: no RNA size: 3308
ORF size: 1194CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2588.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.