Human Gene ZDHHC6 (uc001kzv.3) Description and Page Index
  Description: Homo sapiens zinc finger, DHHC-type containing 6 (ZDHHC6), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:114,190,058-114,206,672 Size: 16,615 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr10:114,190,562-114,205,194 Size: 14,633 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:114,190,058-114,206,672)mRNA (may differ from genome)Protein (413 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZDHC6_HUMAN
DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC6; EC=2.3.1.-; AltName: Full=Transmembrane protein H4; AltName: Full=Zinc finger DHHC domain-containing protein 6; Short=DHHC-6; AltName: Full=Zinc finger protein 376;
FUNCTION: Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.
SEQUENCE CAUTION: Sequence=BAB15462.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZDHHC6
CDC HuGE Published Literature: ZDHHC6

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.13 RPKM in Kidney - Cortex
Total median expression: 740.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.34424-0.350 Picture PostScript Text
3' UTR -93.17504-0.185 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011511 - SH3_2
IPR001452 - SH3_domain
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase
PF07653 - Variant SH3 domain

ModBase Predicted Comparative 3D Structure on Q9H6R6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0018345 protein palmitoylation

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK026369 - Homo sapiens cDNA: FLJ22716 fis, clone HSI13733.
BX647270 - Homo sapiens mRNA; cDNA DKFZp686F2193 (from clone DKFZp686F2193).
AK025605 - Homo sapiens cDNA: FLJ21952 fis, clone HEP04970.
LF211106 - JP 2014500723-A/18609: Polycomb-Associated Non-Coding RNAs.
AK223086 - Homo sapiens mRNA for zinc finger, DHHC domain containing 6 variant, clone: KAT03928.
LF344017 - JP 2014500723-A/151520: Polycomb-Associated Non-Coding RNAs.
JD260782 - Sequence 241806 from Patent EP1572962.
JD059668 - Sequence 40692 from Patent EP1572962.
JD298750 - Sequence 279774 from Patent EP1572962.
JD285734 - Sequence 266758 from Patent EP1572962.
JD402878 - Sequence 383902 from Patent EP1572962.
AF267740 - Homo sapiens transmembrane protein H4 mRNA, complete cds.
JD088991 - Sequence 70015 from Patent EP1572962.
BC007213 - Homo sapiens zinc finger, DHHC-type containing 6, mRNA (cDNA clone MGC:14922 IMAGE:2960984), complete cds.
BC017434 - Homo sapiens zinc finger, DHHC-type containing 6, mRNA (cDNA clone MGC:2790 IMAGE:2960984), complete cds.
JD351392 - Sequence 332416 from Patent EP1572962.
JF432132 - Synthetic construct Homo sapiens clone IMAGE:100073272 zinc finger, DHHC-type containing 6 (ZDHHC6) gene, encodes complete protein.
KJ903079 - Synthetic construct Homo sapiens clone ccsbBroadEn_12473 ZDHHC6 gene, encodes complete protein.
AK308026 - Homo sapiens cDNA, FLJ97974.
LF344016 - JP 2014500723-A/151519: Polycomb-Associated Non-Coding RNAs.
LF344015 - JP 2014500723-A/151518: Polycomb-Associated Non-Coding RNAs.
AK054991 - Homo sapiens cDNA FLJ30429 fis, clone BRACE2008948.
CU675563 - Synthetic construct Homo sapiens gateway clone IMAGE:100019272 5' read ZDHHC6 mRNA.
JD345762 - Sequence 326786 from Patent EP1572962.
JD447338 - Sequence 428362 from Patent EP1572962.
JD470293 - Sequence 451317 from Patent EP1572962.
JD165956 - Sequence 146980 from Patent EP1572962.
JD259597 - Sequence 240621 from Patent EP1572962.
JD128400 - Sequence 109424 from Patent EP1572962.
JD078653 - Sequence 59677 from Patent EP1572962.
JD280632 - Sequence 261656 from Patent EP1572962.
JD295491 - Sequence 276515 from Patent EP1572962.
MA579594 - JP 2018138019-A/151520: Polycomb-Associated Non-Coding RNAs.
MA579593 - JP 2018138019-A/151519: Polycomb-Associated Non-Coding RNAs.
MA579592 - JP 2018138019-A/151518: Polycomb-Associated Non-Coding RNAs.
MA446683 - JP 2018138019-A/18609: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DRB6, NM_022494, NP_071939, Q53G45, Q96IV7, Q9H605, Q9H6R6, ZDHC6_HUMAN, ZNF376
UCSC ID: uc001kzv.3
RefSeq Accession: NM_022494
Protein: Q9H6R6 (aka ZDHC6_HUMAN or ZDH6_HUMAN)
CCDS: CCDS7574.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022494.1
exon count: 11CDS single in 3' UTR: no RNA size: 2187
ORF size: 1242CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 2438.00frame shift in genome: no % Coverage: 99.22
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.