ID:GBLP_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1; AltName: Full=Cell proliferation-inducing gene 21 protein; AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3; AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7; AltName: Full=Receptor for activated C kinase; AltName: Full=Receptor of activated protein kinase C 1; Short=RACK1; FUNCTION: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA. SUBUNIT: Component of the small (40S) ribosomal subunit (By similarity). Exists as a monomer and also forms oligomers. Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of GNB2L1/RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with TBXA2R isoform 2. Interacts with HRAS. Interacts with Y.pseudotuberculosis yopK. Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nef increases Nef phosphorylation by PKC. INTERACTION: P22303:ACHE; NbExp=2; IntAct=EBI-296739, EBI-1637793; O43521:BCL2L11; NbExp=2; IntAct=EBI-296739, EBI-526406; O54918-1:Bcl2l11 (xeno); NbExp=2; IntAct=EBI-296739, EBI-526076; P63167:DYNLL1; NbExp=6; IntAct=EBI-296739, EBI-349105; P48551:IFNAR2; NbExp=4; IntAct=EBI-296739, EBI-958408; Q9Y561:LRP12; NbExp=2; IntAct=EBI-296739, EBI-296693; P40337:VHL; NbExp=9; IntAct=EBI-296739, EBI-301246; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon (By similarity). Cell projection, dendrite (By similarity). Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis. TISSUE SPECIFICITY: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. PTM: Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC. SIMILARITY: Belongs to the WD repeat G protein beta family. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=AAO21313.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAR24619.1; Type=Frameshift; Positions=94; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GNB2L1ID43285ch5q35.html";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GNB2L1 CDC HuGE Published Literature: GNB2L1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P63244
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0006412 translation GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007049 cell cycle GO:0007275 multicellular organism development GO:0007369 gastrulation GO:0010629 negative regulation of gene expression GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0016032 viral process GO:0016567 protein ubiquitination GO:0017148 negative regulation of translation GO:0030178 negative regulation of Wnt signaling pathway GO:0030308 negative regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030822 positive regulation of cAMP catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032464 positive regulation of protein homooligomerization GO:0032880 regulation of protein localization GO:0033137 negative regulation of peptidyl-serine phosphorylation GO:0040008 regulation of growth GO:0042998 positive regulation of Golgi to plasma membrane protein transport GO:0043065 positive regulation of apoptotic process GO:0043473 pigmentation GO:0043547 positive regulation of GTPase activity GO:0048511 rhythmic process GO:0050765 negative regulation of phagocytosis GO:0051302 regulation of cell division GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051726 regulation of cell cycle GO:0051898 negative regulation of protein kinase B signaling GO:0051901 positive regulation of mitochondrial depolarization GO:0061099 negative regulation of protein tyrosine kinase activity GO:0071333 cellular response to glucose stimulus GO:0071363 cellular response to growth factor stimulus GO:0072344 rescue of stalled ribosome GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response GO:1903208 negative regulation of hydrogen peroxide-induced neuron death GO:2000114 regulation of establishment of cell polarity GO:2000304 positive regulation of ceramide biosynthetic process GO:2000543 positive regulation of gastrulation GO:2001244 positive regulation of intrinsic apoptotic signaling pathway