Human Gene GNB2L1 (uc003mni.1) Description and Page Index
  Description: Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:180,663,928-180,670,906 Size: 6,979 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr5:180,663,977-180,670,800 Size: 6,824 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:180,663,928-180,670,906)mRNA (may differ from genome)Protein (317 aa)
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Wikipedia

-  Comments and Description Text from UniProtKB
  ID: GBLP_HUMAN
DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1; AltName: Full=Cell proliferation-inducing gene 21 protein; AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3; AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7; AltName: Full=Receptor for activated C kinase; AltName: Full=Receptor of activated protein kinase C 1; Short=RACK1;
FUNCTION: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.
SUBUNIT: Component of the small (40S) ribosomal subunit (By similarity). Exists as a monomer and also forms oligomers. Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of GNB2L1/RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with TBXA2R isoform 2. Interacts with HRAS. Interacts with Y.pseudotuberculosis yopK. Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nef increases Nef phosphorylation by PKC.
INTERACTION: P22303:ACHE; NbExp=2; IntAct=EBI-296739, EBI-1637793; O43521:BCL2L11; NbExp=2; IntAct=EBI-296739, EBI-526406; O54918-1:Bcl2l11 (xeno); NbExp=2; IntAct=EBI-296739, EBI-526076; P63167:DYNLL1; NbExp=6; IntAct=EBI-296739, EBI-349105; P48551:IFNAR2; NbExp=4; IntAct=EBI-296739, EBI-958408; Q9Y561:LRP12; NbExp=2; IntAct=EBI-296739, EBI-296693; P40337:VHL; NbExp=9; IntAct=EBI-296739, EBI-301246;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon (By similarity). Cell projection, dendrite (By similarity). Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis.
TISSUE SPECIFICITY: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.
PTM: Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC.
SIMILARITY: Belongs to the WD repeat G protein beta family.
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=AAO21313.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAR24619.1; Type=Frameshift; Positions=94;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GNB2L1ID43285ch5q35.html";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GNB2L1
CDC HuGE Published Literature: GNB2L1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 394.14 RPKM in Ovary
Total median expression: 7556.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.60106-0.430 Picture PostScript Text
3' UTR -4.4549-0.091 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

4AOW
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P63244
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005080 protein kinase C binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008200 ion channel inhibitor activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030292 protein tyrosine kinase inhibitor activity
GO:0030332 cyclin binding
GO:0030971 receptor tyrosine kinase binding
GO:0032947 protein complex scaffold
GO:0035591 signaling adaptor activity
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0043022 ribosome binding
GO:0045296 cadherin binding

Biological Process:
GO:0001934 positive regulation of protein phosphorylation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049 cell cycle
GO:0007275 multicellular organism development
GO:0007369 gastrulation
GO:0010629 negative regulation of gene expression
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0017148 negative regulation of translation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030822 positive regulation of cAMP catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464 positive regulation of protein homooligomerization
GO:0032880 regulation of protein localization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0040008 regulation of growth
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
GO:0043065 positive regulation of apoptotic process
GO:0043473 pigmentation
GO:0043547 positive regulation of GTPase activity
GO:0048511 rhythmic process
GO:0050765 negative regulation of phagocytosis
GO:0051302 regulation of cell division
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0071333 cellular response to glucose stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0072344 rescue of stalled ribosome
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:2000114 regulation of establishment of cell polarity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000543 positive regulation of gastrulation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Cellular Component:
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0030425 dendrite
GO:0030496 midbody
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:1990630 IRE1-RACK1-PP2A complex


-  Descriptions from all associated GenBank mRNAs
  BC021993 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:24470 IMAGE:4083071), complete cds.
BC029996 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone IMAGE:4519568).
AK095666 - Homo sapiens cDNA FLJ38347 fis, clone FCBBF4000173, highly similar to Guanine nucleotide-binding protein subunit beta 2-like 1.
AK301468 - Homo sapiens cDNA FLJ52787 complete cds, highly similar to Guanine nucleotide-binding protein subunitbeta 2-like 1.
BC019093 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:29656 IMAGE:4893346), complete cds.
BC032006 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:21438 IMAGE:4750184), complete cds.
AY159316 - Homo sapiens lung cancer oncogene 7 mRNA, complete cds.
BC019362 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:3561 IMAGE:2823761), complete cds.
BC000672 - Homo sapiens cDNA clone IMAGE:3350045, **** WARNING: chimeric clone ****.
BC014582 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone IMAGE:3996513), **** WARNING: chimeric clone ****.
M24194 - Human MHC protein homologous to chicken B complex protein mRNA, complete cds.
BC017287 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:29695 IMAGE:4892271), complete cds.
BC014256 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:20686 IMAGE:4765908), complete cds.
BC010119 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:19788 IMAGE:3835636), complete cds.
BC000366 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:8325 IMAGE:2819249), complete cds.
BC000214 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:2416 IMAGE:2959178), complete cds.
BC014788 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:9338 IMAGE:3455986), complete cds.
BC035460 - Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone IMAGE:4705256).
AK222488 - Homo sapiens mRNA for guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 variant, clone: adKA02454.
AK124177 - Homo sapiens cDNA FLJ42183 fis, clone THYMU2031890.
AY336089 - Homo sapiens proliferation-inducing gene 21 mRNA, complete cds.
GU727632 - Homo sapiens epididymis tissue sperm binding protein Li 3a mRNA, complete cds.
DQ891422 - Synthetic construct clone IMAGE:100004052; FLH176787.01X; RZPDo839H04122D guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1) gene, encodes complete protein.
KJ898203 - Synthetic construct Homo sapiens clone ccsbBroadEn_07597 GNB2L1 gene, encodes complete protein.
KJ906040 - Synthetic construct Homo sapiens clone ccsbBroadEn_15710 GNB2L1 gene, encodes complete protein.
DQ894596 - Synthetic construct Homo sapiens clone IMAGE:100009056; FLH176783.01L; RZPDo839H04121D guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1) gene, encodes complete protein.
CR541909 - Homo sapiens full open reading frame cDNA clone RZPDo834H0433D for gene GNB2L1, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; complete cds, without stopcodon.
AM393661 - Synthetic construct Homo sapiens clone IMAGE:100002008 for hypothetical protein (GNB2L1 gene).
AB463707 - Synthetic construct DNA, clone: pF1KB8255, Homo sapiens GNB2L1 gene for guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, without stop codon, in Flexi system.
CR456978 - Homo sapiens full open reading frame cDNA clone RZPDo834C085D for gene GNB2L1, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; complete cds, incl. stopcodon.
CU689260 - Synthetic construct Homo sapiens gateway clone IMAGE:100018874 5' read GNB2L1 mRNA.
AK301029 - Homo sapiens cDNA FLJ60170 complete cds, highly similar to Guanine nucleotide-binding protein subunit beta 2-like 1.
AK310916 - Homo sapiens cDNA, FLJ17958.
JD025729 - Sequence 6753 from Patent EP1572962.
JD035520 - Sequence 16544 from Patent EP1572962.
JD020462 - Sequence 1486 from Patent EP1572962.
AK303316 - Homo sapiens cDNA FLJ56705 complete cds, highly similar to Guanine nucleotide-binding protein subunit beta 2-like 1.
JN104586 - Homo sapiens guanine nucleotide binding protein beta polypeptide 2-like 1 (GNB2L1) mRNA, partial cds.
JD024275 - Sequence 5299 from Patent EP1572962.
JD029730 - Sequence 10754 from Patent EP1572962.
D28398 - Homo sapiens mRNA for G protein beta subunit-like protein 12.3, 5'UTR region.
JD462644 - Sequence 443668 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P63244 (Reactome details) participates in the following event(s):

R-HSA-5626962 GNB2L1 binds IKKA:IKKB:NEMO
R-HSA-5626982 TNF-alpha:TNFR1:NSMAF binds GNB2L1
R-HSA-5626981 TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5626978 TNFR1-mediated ceramide production
R-HSA-75893 TNF signaling
R-HSA-73887 Death Receptor Signalling
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B3KTJ0, D3DWS0, GBLP_HUMAN, HLC7, NM_006098, NP_006089, P25388, P63244, P99049, PIG21, Q53HU2, Q5J8M6, Q5VLR4, Q6FH47
UCSC ID: uc003mni.1
RefSeq Accession: NM_006098
Protein: P63244 (aka GBLP_HUMAN)
CCDS: CCDS34324.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006098.4
exon count: 8CDS single in 3' UTR: no RNA size: 1125
ORF size: 954CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2108.00frame shift in genome: no % Coverage: 98.58
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.