Human Gene ARF1 (uc001hrr.3) Description and Page Index
Description: Homo sapiens ADP-ribosylation factor 1 (ARF1), transcript variant 3, mRNA. RefSeq Summary (NM_001024226): ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:228,270,361-228,286,913 Size: 16,553 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr1:228,284,816-228,285,714 Size: 899 Coding Exon Count: 4
ID:ARF1_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor 1; FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. SUBUNIT: Interacts with PRKCABP, GGA1 and PIP5K1B (By similarity). Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with ASAP2, HERC1 and ARHGAP21. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. This interaction at the plasma membrane requires a myristoylated NCS1/FREQ. Interacts with TMED2 and TMED10. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for the FAPP2-mediated glucosylceramide transfer activity. INTERACTION: Q99418:CYTH2; NbExp=4; IntAct=EBI-447171, EBI-448974; SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, perinuclear region. SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): ARF1 CDC HuGE Published Literature: ARF1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family PF00071 - Ras family PF01926 - 50S ribosome-binding GTPase PF04670 - Gtr1/RagA G protein conserved region PF08477 - Ras of Complex, Roc, domain of DAPkinase PF09439 - Signal recognition particle receptor beta subunit
ModBase Predicted Comparative 3D Structure on P84077
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002090 regulation of receptor internalization GO:0006661 phosphatidylinositol biosynthetic process GO:0006878 cellular copper ion homeostasis GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation GO:0035722 interleukin-12-mediated signaling pathway GO:0050690 regulation of defense response to virus by virus GO:0060292 long term synaptic depression GO:0097061 dendritic spine organization GO:0098586 cellular response to virus