Human Gene RPS27 (uc001fdv.3) Description and Page Index
Description: Homo sapiens ribosomal protein S27 (RPS27), mRNA. RefSeq Summary (NM_001030): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]. Transcript (Including UTRs) Position: hg19 chr1:153,963,239-153,964,631 Size: 1,393 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr1:153,963,273-153,964,569 Size: 1,297 Coding Exon Count: 4
ID:RS27_HUMAN DESCRIPTION: RecName: Full=40S ribosomal protein S27; AltName: Full=Metallopan-stimulin 1; Short=MPS-1; COFACTOR: Binds 1 zinc ion per subunit (Potential). INTERACTION: Q00987:MDM2; NbExp=5; IntAct=EBI-356336, EBI-389668; TISSUE SPECIFICITY: Expressed in a wide variety of actively proliferating cells and tumor tissues. SIMILARITY: Belongs to the ribosomal protein S27e family. CAUTION: Was originally (PubMed:8407955) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P42677
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.