Description: Homo sapiens nucleolar protein 8 (NOL8), transcript variant 1, mRNA. RefSeq Summary (NM_017948): NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr9:95,059,640-95,087,876 Size: 28,237 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr9:95,060,118-95,086,443 Size: 26,326 Coding Exon Count: 16
ID:NOL8_HUMAN DESCRIPTION: RecName: Full=Nucleolar protein 8; AltName: Full=Nucleolar protein Nop132; FUNCTION: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. SUBUNIT: Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA- dependent. Interacts with DDX47; the interaction is RNA-dependent. SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. TISSUE SPECIFICITY: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. INDUCTION: Up-regulated in diffuse-type gastric cancers. PTM: Phosphorylated (Probable). SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=BAA91356.1; Type=Frameshift; Positions=1136; Sequence=BAB14229.1; Type=Erroneous initiation; Sequence=BAB15003.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q76FK4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
