Human Gene MED22 (uc004cdc.3) Description and Page Index
Description: Homo sapiens mediator complex subunit 22 (MED22), transcript variant b, mRNA. RefSeq Summary (NM_133640): This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr9:136,207,755-136,214,972 Size: 7,218 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr9:136,208,355-136,213,517 Size: 5,163 Coding Exon Count: 4
ID:MED22_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 22; AltName: Full=Mediator complex subunit 22; AltName: Full=Surfeit locus protein 5; Short=Surf-5; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. INTERACTION: Q9P086:MED11; NbExp=3; IntAct=EBI-394687, EBI-394704; Q9CQI9:Med30 (xeno); NbExp=4; IntAct=EBI-394687, EBI-309220; SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the Mediator complex subunit 22 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MED22 CDC HuGE Published Literature: MED22
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06179 - Surfeit locus protein 5 subunit 22 of Mediator complex
ModBase Predicted Comparative 3D Structure on Q15528
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.