Human Gene KCTD18 (uc002uvs.3) Description and Page Index
  Description: Homo sapiens potassium channel tetramerisation domain containing 18 (KCTD18), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:201,353,684-201,374,792 Size: 21,109 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr2:201,354,823-201,371,739 Size: 16,917 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:201,353,684-201,374,792)mRNA (may differ from genome)Protein (426 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=BTB/POZ domain-containing protein KCTD18;
SIMILARITY: Contains 1 BTB (POZ) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.05 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 318.07 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -262.61517-0.508 Picture PostScript Text
3' UTR -282.101139-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR003131 - T1-type_BTB

Pfam Domains:
PF02214 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q6PI47
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051260 protein homooligomerization

-  Descriptions from all associated GenBank mRNAs
  AK095137 - Homo sapiens cDNA FLJ37818 fis, clone BRSSN2003841.
BC059366 - Homo sapiens potassium channel tetramerisation domain containing 18, mRNA (cDNA clone IMAGE:5264059).
BC045189 - Homo sapiens potassium channel tetramerisation domain containing 18, mRNA (cDNA clone MGC:44387 IMAGE:5296647), complete cds.
BC067755 - Homo sapiens potassium channel tetramerisation domain containing 18, mRNA (cDNA clone MGC:87030 IMAGE:5299303), complete cds.
JD314202 - Sequence 295226 from Patent EP1572962.
JD195255 - Sequence 176279 from Patent EP1572962.
AK290867 - Homo sapiens cDNA FLJ76153 complete cds, highly similar to Homo sapiens potassium channel tetramerisation domain containing 18 (KCTD18), mRNA.
JD045096 - Sequence 26120 from Patent EP1572962.
JD241507 - Sequence 222531 from Patent EP1572962.
JD344872 - Sequence 325896 from Patent EP1572962.
AK055884 - Homo sapiens cDNA FLJ31322 fis, clone LIVER2000033, weakly similar to TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1, ENDOTHELIAL.
JD277265 - Sequence 258289 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KCD18_HUMAN, NM_152387, NP_689600, Q53T21, Q6NW26, Q6PCD8, Q6PI47, Q8N9B7, Q96N73
UCSC ID: uc002uvs.3
RefSeq Accession: NM_152387
Protein: Q6PI47 (aka KCD18_HUMAN)
CCDS: CCDS2330.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_152387.2
exon count: 7CDS single in 3' UTR: no RNA size: 2959
ORF size: 1281CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2412.00frame shift in genome: no % Coverage: 99.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.