Human Gene LIG3 (uc002hik.2) Description and Page Index
Description: Homo sapiens ligase III, DNA, ATP-dependent (LIG3), nuclear gene encoding mitochondrial protein, transcript variant alpha, mRNA. RefSeq Summary (NM_013975): This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:33,307,517-33,332,088 Size: 24,572 Total Exon Count: 20 Strand: + Coding Region Position: hg19 chr17:33,310,025-33,331,525 Size: 21,501 Coding Exon Count: 19
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00645 - Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PF01068 - ATP dependent DNA ligase domain PF04675 - DNA ligase N terminus PF04679 - ATP dependent DNA ligase C terminal region PF16589 - BRCT domain, a BRCA1 C-terminus domain PF16759 - DNA ligase 3 BRCT domain
ModBase Predicted Comparative 3D Structure on P49916
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-110376 Recruitment of LIG3:XRCC1 complex to the site of repair by POLB R-HSA-5649726 LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA R-HSA-5687673 MRN recruits LIG3:XRCC1 to MMEJ sites R-HSA-110380 Dissociation of LIG3:XRCC1 complex from the BER site R-HSA-5649724 LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site R-HSA-5687675 LIG3 ligates remaining SSBs in MMEJ R-HSA-73932 Resynthesis of excised residue by POLB R-HSA-73931 LIG3-mediated DNA ligation via the single-nucleotide replacement pathway R-HSA-5649734 LIG3 ligates NEIL1,NEIL2-generated single strand break R-HSA-5649705 PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) R-HSA-5649723 POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution R-HSA-5690997 Ligation of newly synthesized repair patch to incised DNA in GG-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5685939 HDR through MMEJ (alt-NHEJ) R-HSA-73933 Resolution of Abasic Sites (AP sites) R-HSA-5693538 Homology Directed Repair R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-73884 Base Excision Repair R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-73894 DNA Repair R-HSA-5696398 Nucleotide Excision Repair