Human Gene METTL21A (uc010fuk.1)
  Description: Homo sapiens methyltransferase like 21A (METTL21A), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:208,473,839-208,489,973 Size: 16,135 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:208,477,770-208,489,099 Size: 11,330 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:208,473,839-208,489,973)mRNA (may differ from genome)Protein (218 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MT21A_HUMAN
DESCRIPTION: RecName: Full=Methyltransferase-like protein 21A; EC=2.1.1.-; AltName: Full=Hepatocellular carcinoma-associated antigen 557b;
FUNCTION: Probable methyltransferase (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the methyltransferase superfamily. METTL21 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D001564 Benzo(a)pyrene
  • D019327 Copper Sulfate
  • D003993 Dibutyl Phthalate
  • D006861 Hydrogen Peroxide
  • D011794 Quercetin
  • C513635 S-2-pentyl-4-pentynoic hydroxamic acid
  • D012822 Silicon Dioxide
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.77 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 69.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -115.60217-0.533 Picture PostScript Text
3' UTR -1614.043931-0.411 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019410 - Nicotinamide_N-MeTfrase-like

Pfam Domains:
PF06325 - Ribosomal protein L11 methyltransferase (PrmA)
PF10294 - Lysine methyltransferase

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q8WXB1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0016740 transferase activity
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0051117 ATPase binding

Biological Process:
GO:0006479 protein methylation
GO:0018022 peptidyl-lysine methylation
GO:0032259 methylation
GO:0043462 regulation of ATPase activity

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  BC009462 - Homo sapiens family with sequence similarity 119, member A, mRNA (cDNA clone IMAGE:3542748), complete cds.
JD481435 - Sequence 462459 from Patent EP1572962.
DQ582565 - Homo sapiens piRNA piR-32677, complete sequence.
DQ577392 - Homo sapiens piRNA piR-45504, complete sequence.
JD476302 - Sequence 457326 from Patent EP1572962.
JD476303 - Sequence 457327 from Patent EP1572962.
JD413932 - Sequence 394956 from Patent EP1572962.
JD122242 - Sequence 103266 from Patent EP1572962.
JD163550 - Sequence 144574 from Patent EP1572962.
JD408871 - Sequence 389895 from Patent EP1572962.
JD069378 - Sequence 50402 from Patent EP1572962.
JD476297 - Sequence 457321 from Patent EP1572962.
JD476296 - Sequence 457320 from Patent EP1572962.
JD476294 - Sequence 457318 from Patent EP1572962.
JD111472 - Sequence 92496 from Patent EP1572962.
JD297596 - Sequence 278620 from Patent EP1572962.
JD500244 - Sequence 481268 from Patent EP1572962.
JD163552 - Sequence 144576 from Patent EP1572962.
JD425783 - Sequence 406807 from Patent EP1572962.
JD395733 - Sequence 376757 from Patent EP1572962.
JD086281 - Sequence 67305 from Patent EP1572962.
JD069377 - Sequence 50401 from Patent EP1572962.
JD476296 - Sequence 457320 from Patent EP1572962.
JD069378 - Sequence 50402 from Patent EP1572962.
JD476297 - Sequence 457321 from Patent EP1572962.
JD476294 - Sequence 457318 from Patent EP1572962.
JD476295 - Sequence 457319 from Patent EP1572962.
JD086281 - Sequence 67305 from Patent EP1572962.
JD069377 - Sequence 50401 from Patent EP1572962.
JD476296 - Sequence 457320 from Patent EP1572962.
JD476297 - Sequence 457321 from Patent EP1572962.
JD476294 - Sequence 457318 from Patent EP1572962.
JD476295 - Sequence 457319 from Patent EP1572962.
JD111472 - Sequence 92496 from Patent EP1572962.
JD297596 - Sequence 278620 from Patent EP1572962.
JD500244 - Sequence 481268 from Patent EP1572962.
JD163552 - Sequence 144576 from Patent EP1572962.
JD408871 - Sequence 389895 from Patent EP1572962.
DQ594303 - Homo sapiens piRNA piR-60415, complete sequence.
JD373845 - Sequence 354869 from Patent EP1572962.
JD067605 - Sequence 48629 from Patent EP1572962.
JD067606 - Sequence 48630 from Patent EP1572962.
JD306515 - Sequence 287539 from Patent EP1572962.
JD085749 - Sequence 66773 from Patent EP1572962.
JD527363 - Sequence 508387 from Patent EP1572962.
JD311394 - Sequence 292418 from Patent EP1572962.
JD311395 - Sequence 292419 from Patent EP1572962.
JD311393 - Sequence 292417 from Patent EP1572962.
DQ587652 - Homo sapiens piRNA piR-54764, complete sequence.
DQ587653 - Homo sapiens piRNA piR-54765, complete sequence.
DQ589647 - Homo sapiens piRNA piR-56759, complete sequence.
BC033720 - Homo sapiens family with sequence similarity 119, member A, mRNA (cDNA clone MGC:45373 IMAGE:4934087), complete cds.
AK093812 - Homo sapiens cDNA FLJ36493 fis, clone THYMU2018547.
AX748320 - Sequence 1845 from Patent EP1308459.
JD066613 - Sequence 47637 from Patent EP1572962.
JD138408 - Sequence 119432 from Patent EP1572962.
JD176409 - Sequence 157433 from Patent EP1572962.
JD249791 - Sequence 230815 from Patent EP1572962.
JD148269 - Sequence 129293 from Patent EP1572962.
JD463782 - Sequence 444806 from Patent EP1572962.
JD478540 - Sequence 459564 from Patent EP1572962.
JD543230 - Sequence 524254 from Patent EP1572962.
JD537271 - Sequence 518295 from Patent EP1572962.
JD463783 - Sequence 444807 from Patent EP1572962.
JD478541 - Sequence 459565 from Patent EP1572962.
JD543231 - Sequence 524255 from Patent EP1572962.
JD309527 - Sequence 290551 from Patent EP1572962.
JD550821 - Sequence 531845 from Patent EP1572962.
AF455817 - Homo sapiens hepatocellular carcinoma-associated antigen HCA557b mRNA, complete cds.
JD302475 - Sequence 283499 from Patent EP1572962.
JD359895 - Sequence 340919 from Patent EP1572962.
JD507231 - Sequence 488255 from Patent EP1572962.
JD330502 - Sequence 311526 from Patent EP1572962.
KJ900284 - Synthetic construct Homo sapiens clone ccsbBroadEn_09678 METTL21A gene, encodes complete protein.
KJ903879 - Synthetic construct Homo sapiens clone ccsbBroadEn_13273 METTL21A gene, encodes complete protein.
JD066110 - Sequence 47134 from Patent EP1572962.
JD078803 - Sequence 59827 from Patent EP1572962.
JD260307 - Sequence 241331 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WXB1 (Reactome details) participates in the following event(s):

R-HSA-8932221 METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8
R-HSA-8876725 Protein methylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: FAM119A, HCA557B, MT21A_HUMAN, NM_001127395, NP_660323, Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6
UCSC ID: uc010fuk.1
RefSeq Accession: NM_001127395
Protein: Q8WXB1 (aka MT21A_HUMAN)
CCDS: CCDS2376.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001127395.1
exon count: 4CDS single in 3' UTR: no RNA size: 4805
ORF size: 657CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1496.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.