Human Gene METTL21A (uc010fuk.1)
Description: Homo sapiens methyltransferase like 21A (METTL21A), transcript variant 2, mRNA.
Transcript (Including UTRs)
Position: hg19 chr2:208,473,839-208,489,973 Size: 16,135 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr2:208,477,770-208,489,099 Size: 11,330 Coding Exon Count: 3
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MT21A_HUMAN
DESCRIPTION: RecName: Full=Methyltransferase-like protein 21A; EC=2.1.1.-; AltName: Full=Hepatocellular carcinoma-associated antigen 557b;
FUNCTION: Probable methyltransferase (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).SIMILARITY: Belongs to the methyltransferase superfamily. METTL21 family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR019410 - Nicotinamide_N-MeTfrase-like
Pfam Domains: PF06325 - Ribosomal protein L11 methyltransferase (PrmA)
PF10294 - Lysine methyltransferase
SCOP Domains: 53335 - S-adenosyl-L-methionine-dependent methyltransferases
ModBase Predicted Comparative 3D Structure on Q8WXB1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC009462 - Homo sapiens family with sequence similarity 119, member A, mRNA (cDNA clone IMAGE:3542748), complete cds.JD481435 - Sequence 462459 from Patent EP1572962.DQ582565 - Homo sapiens piRNA piR-32677, complete sequence.DQ577392 - Homo sapiens piRNA piR-45504, complete sequence.JD476302 - Sequence 457326 from Patent EP1572962.JD476303 - Sequence 457327 from Patent EP1572962.JD413932 - Sequence 394956 from Patent EP1572962.JD122242 - Sequence 103266 from Patent EP1572962.JD163550 - Sequence 144574 from Patent EP1572962.JD408871 - Sequence 389895 from Patent EP1572962.JD069378 - Sequence 50402 from Patent EP1572962.JD476297 - Sequence 457321 from Patent EP1572962.JD476296 - Sequence 457320 from Patent EP1572962.JD476294 - Sequence 457318 from Patent EP1572962.JD111472 - Sequence 92496 from Patent EP1572962.JD297596 - Sequence 278620 from Patent EP1572962.JD500244 - Sequence 481268 from Patent EP1572962.JD163552 - Sequence 144576 from Patent EP1572962.JD425783 - Sequence 406807 from Patent EP1572962.JD395733 - Sequence 376757 from Patent EP1572962.JD086281 - Sequence 67305 from Patent EP1572962.JD069377 - Sequence 50401 from Patent EP1572962.JD476296 - Sequence 457320 from Patent EP1572962.JD069378 - Sequence 50402 from Patent EP1572962.JD476297 - Sequence 457321 from Patent EP1572962.JD476294 - Sequence 457318 from Patent EP1572962.JD476295 - Sequence 457319 from Patent EP1572962.JD086281 - Sequence 67305 from Patent EP1572962.JD069377 - Sequence 50401 from Patent EP1572962.JD476296 - Sequence 457320 from Patent EP1572962.JD476297 - Sequence 457321 from Patent EP1572962.JD476294 - Sequence 457318 from Patent EP1572962.JD476295 - Sequence 457319 from Patent EP1572962.JD111472 - Sequence 92496 from Patent EP1572962.JD297596 - Sequence 278620 from Patent EP1572962.JD500244 - Sequence 481268 from Patent EP1572962.JD163552 - Sequence 144576 from Patent EP1572962.JD408871 - Sequence 389895 from Patent EP1572962.DQ594303 - Homo sapiens piRNA piR-60415, complete sequence.JD373845 - Sequence 354869 from Patent EP1572962.JD067605 - Sequence 48629 from Patent EP1572962.JD067606 - Sequence 48630 from Patent EP1572962.JD306515 - Sequence 287539 from Patent EP1572962.JD085749 - Sequence 66773 from Patent EP1572962.JD527363 - Sequence 508387 from Patent EP1572962.JD311394 - Sequence 292418 from Patent EP1572962.JD311395 - Sequence 292419 from Patent EP1572962.JD311393 - Sequence 292417 from Patent EP1572962.DQ587652 - Homo sapiens piRNA piR-54764, complete sequence.DQ587653 - Homo sapiens piRNA piR-54765, complete sequence.DQ589647 - Homo sapiens piRNA piR-56759, complete sequence.BC033720 - Homo sapiens family with sequence similarity 119, member A, mRNA (cDNA clone MGC:45373 IMAGE:4934087), complete cds.AK093812 - Homo sapiens cDNA FLJ36493 fis, clone THYMU2018547.AX748320 - Sequence 1845 from Patent EP1308459.JD066613 - Sequence 47637 from Patent EP1572962.JD138408 - Sequence 119432 from Patent EP1572962.JD176409 - Sequence 157433 from Patent EP1572962.JD249791 - Sequence 230815 from Patent EP1572962.JD148269 - Sequence 129293 from Patent EP1572962.JD463782 - Sequence 444806 from Patent EP1572962.JD478540 - Sequence 459564 from Patent EP1572962.JD543230 - Sequence 524254 from Patent EP1572962.JD537271 - Sequence 518295 from Patent EP1572962.JD463783 - Sequence 444807 from Patent EP1572962.JD478541 - Sequence 459565 from Patent EP1572962.JD543231 - Sequence 524255 from Patent EP1572962.JD309527 - Sequence 290551 from Patent EP1572962.JD550821 - Sequence 531845 from Patent EP1572962.AF455817 - Homo sapiens hepatocellular carcinoma-associated antigen HCA557b mRNA, complete cds.JD302475 - Sequence 283499 from Patent EP1572962.JD359895 - Sequence 340919 from Patent EP1572962.JD507231 - Sequence 488255 from Patent EP1572962.JD330502 - Sequence 311526 from Patent EP1572962.KJ900284 - Synthetic construct Homo sapiens clone ccsbBroadEn_09678 METTL21A gene, encodes complete protein.KJ903879 - Synthetic construct Homo sapiens clone ccsbBroadEn_13273 METTL21A gene, encodes complete protein.JD066110 - Sequence 47134 from Patent EP1572962.JD078803 - Sequence 59827 from Patent EP1572962.JD260307 - Sequence 241331 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: FAM119A, HCA557B, MT21A_HUMAN, NM_001127395, NP_660323, Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6UCSC ID: uc010fuk.1RefSeq Accession: NM_001127395
Protein: Q8WXB1
(aka MT21A_HUMAN)
CCDS: CCDS2376.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001127395.1
exon count:
4 CDS single in 3' UTR:
no
RNA size:
4805
ORF size:
657 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
1496.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.