ID:COMD5_HUMAN DESCRIPTION: RecName: Full=COMM domain-containing protein 5; AltName: Full=Hypertension-related calcium-regulated gene protein; Short=HCaRG; FUNCTION: Down-regulates activation of NF-kappa-B. SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. SIMILARITY: Contains 1 COMM domain. SEQUENCE CAUTION: Sequence=AAF14877.1; Type=Frameshift; Positions=66, 84, 112, 136;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): COMMD5 CDC HuGE Published Literature: COMMD5 Positive Disease Associations: Kidney Diseases Related Studies:
Kidney Diseases Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZQ3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.