Human Gene ZNF696 (uc003yxy.4) Description and Page Index
  Description: Homo sapiens zinc finger protein 696 (ZNF696), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:144,373,559-144,382,120 Size: 8,562 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr8:144,375,172-144,378,970 Size: 3,799 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:144,373,559-144,382,120)mRNA (may differ from genome)Protein (374 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 696;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.82 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 82.07 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -199.10409-0.487 Picture PostScript Text
3' UTR -1233.483150-0.392 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9H7X3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK024191 - Homo sapiens cDNA FLJ14129 fis, clone MAMMA1002617, weakly similar to ZINC FINGER PROTEIN 135.
BC126317 - Homo sapiens zinc finger protein 696, mRNA (cDNA clone MGC:161595 IMAGE:8992033), complete cds.
JD183624 - Sequence 164648 from Patent EP1572962.
JD465258 - Sequence 446282 from Patent EP1572962.
JD196553 - Sequence 177577 from Patent EP1572962.
JD461920 - Sequence 442944 from Patent EP1572962.
JD107372 - Sequence 88396 from Patent EP1572962.
JD117584 - Sequence 98608 from Patent EP1572962.
HQ258401 - Synthetic construct Homo sapiens clone IMAGE:100072830 Unknown protein gene, encodes complete protein.
JD067375 - Sequence 48399 from Patent EP1572962.
JD554571 - Sequence 535595 from Patent EP1572962.
JD076547 - Sequence 57571 from Patent EP1572962.
JD396101 - Sequence 377125 from Patent EP1572962.
JD220333 - Sequence 201357 from Patent EP1572962.
JD222253 - Sequence 203277 from Patent EP1572962.
JD538372 - Sequence 519396 from Patent EP1572962.
JD089541 - Sequence 70565 from Patent EP1572962.
JD051405 - Sequence 32429 from Patent EP1572962.
JD100855 - Sequence 81879 from Patent EP1572962.
JD158794 - Sequence 139818 from Patent EP1572962.
JD275654 - Sequence 256678 from Patent EP1572962.
JD208637 - Sequence 189661 from Patent EP1572962.
JD294454 - Sequence 275478 from Patent EP1572962.
JD278352 - Sequence 259376 from Patent EP1572962.
JD144620 - Sequence 125644 from Patent EP1572962.
JD196488 - Sequence 177512 from Patent EP1572962.
JD144160 - Sequence 125184 from Patent EP1572962.
JD135973 - Sequence 116997 from Patent EP1572962.
JD048124 - Sequence 29148 from Patent EP1572962.
JD506593 - Sequence 487617 from Patent EP1572962.
JD561263 - Sequence 542287 from Patent EP1572962.
JD277193 - Sequence 258217 from Patent EP1572962.
JD215940 - Sequence 196964 from Patent EP1572962.
JD401710 - Sequence 382734 from Patent EP1572962.
JD448780 - Sequence 429804 from Patent EP1572962.
JD526999 - Sequence 508023 from Patent EP1572962.
JD425499 - Sequence 406523 from Patent EP1572962.
JD483097 - Sequence 464121 from Patent EP1572962.
JD116147 - Sequence 97171 from Patent EP1572962.
JD232695 - Sequence 213719 from Patent EP1572962.
JD072571 - Sequence 53595 from Patent EP1572962.
JD223731 - Sequence 204755 from Patent EP1572962.
JD050280 - Sequence 31304 from Patent EP1572962.
JD078561 - Sequence 59585 from Patent EP1572962.
JD556281 - Sequence 537305 from Patent EP1572962.
JD437105 - Sequence 418129 from Patent EP1572962.
JD063123 - Sequence 44147 from Patent EP1572962.
JD517424 - Sequence 498448 from Patent EP1572962.
JD340804 - Sequence 321828 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H7X3 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVE2, NM_030895, NP_112157, Q9H7X3, ZN696_HUMAN
UCSC ID: uc003yxy.4
RefSeq Accession: NM_030895
Protein: Q9H7X3 (aka ZN696_HUMAN)
CCDS: CCDS6399.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_030895.2
exon count: 3CDS single in 3' UTR: no RNA size: 4686
ORF size: 1125CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2402.00frame shift in genome: no % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.