ID:NANP_HUMAN DESCRIPTION: RecName: Full=N-acylneuraminate-9-phosphatase; EC=18.104.22.168; AltName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 4; AltName: Full=Neu5Ac-9-Pase; CATALYTIC ACTIVITY: N-acylneuraminate 9-phosphate + H(2)O = N- acylneuraminate + phosphate. COFACTOR: Magnesium. ENZYME REGULATION: Inhibited by vanadate and calcium. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P; KM=19.2 mM for fructose 1,6-P2; KM=2.7 mM for 6-P-gluconate; KM=5.9 mM for N-acetylglucosamine 6-P; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate; Vmax=0.001 umol/min/mg enzyme with ATP as substrate; PATHWAY: Amino-sugar metabolism; N-acetylneuraminate biosynthesis. SIMILARITY: Belongs to the HAD-like hydrolase superfamily. NANP family. SEQUENCE CAUTION: Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TBE9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.