Human Gene NANP (uc002wuy.3) Description and Page Index
  Description: Homo sapiens N-acetylneuraminic acid phosphatase (NANP), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr20:25,593,573-25,604,648 Size: 11,076 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr20:25,596,561-25,604,584 Size: 8,024 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:25,593,573-25,604,648)mRNA (may differ from genome)Protein (248 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=N-acylneuraminate-9-phosphatase; EC=; AltName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 4; AltName: Full=Neu5Ac-9-Pase;
CATALYTIC ACTIVITY: N-acylneuraminate 9-phosphate + H(2)O = N- acylneuraminate + phosphate.
COFACTOR: Magnesium.
ENZYME REGULATION: Inhibited by vanadate and calcium.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P; KM=19.2 mM for fructose 1,6-P2; KM=2.7 mM for 6-P-gluconate; KM=5.9 mM for N-acetylglucosamine 6-P; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate; Vmax=0.001 umol/min/mg enzyme with ATP as substrate;
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate biosynthesis.
SIMILARITY: Belongs to the HAD-like hydrolase superfamily. NANP family.
SEQUENCE CAUTION: Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA;

-  MalaCards Disease Associations
  MalaCards Gene Search: NANP
Diseases sorted by gene-association score: parasitic protozoa infectious disease (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.34 RPKM in Adrenal Gland
Total median expression: 68.78 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.2064-0.488 Picture PostScript Text
3' UTR -813.932988-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023214 - HAD-like_dom
IPR011950 - HAD-SF_hydro_IA_CTE7
IPR006439 - HAD-SF_hydro_IA_v1
IPR005833 - Haloacid_DH/epoxide_hydro

Pfam Domains:
PF00702 - haloacid dehalogenase-like hydrolase
PF13242 - HAD-hyrolase-like
PF13419 - Haloacid dehalogenase-like hydrolase

SCOP Domains:
56784 - HAD-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q8TBE9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016787 hydrolase activity
GO:0050124 N-acylneuraminate-9-phosphatase activity

Biological Process:
GO:0005975 carbohydrate metabolic process
GO:0006045 N-acetylglucosamine biosynthetic process
GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0046380 N-acetylneuraminate biosynthetic process

Cellular Component:
GO:0005575 cellular_component
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AL833116 - Homo sapiens mRNA; cDNA DKFZp313O1829 (from clone DKFZp313O1829).
BC003415 - Homo sapiens N-acetylneuraminic acid phosphatase, mRNA (cDNA clone IMAGE:3451161), with apparent retained intron.
BC022552 - Homo sapiens N-acetylneuraminic acid phosphatase, mRNA (cDNA clone MGC:26833 IMAGE:4819016), complete cds.
AK055472 - Homo sapiens cDNA FLJ30910 fis, clone FEBRA2006270, highly similar to N-acylneuraminate-9-phosphatase (EC
JD376974 - Sequence 357998 from Patent EP1572962.
JD150096 - Sequence 131120 from Patent EP1572962.
JD342332 - Sequence 323356 from Patent EP1572962.
JD293483 - Sequence 274507 from Patent EP1572962.
JD504467 - Sequence 485491 from Patent EP1572962.
JD362233 - Sequence 343257 from Patent EP1572962.
JD121074 - Sequence 102098 from Patent EP1572962.
JD321556 - Sequence 302580 from Patent EP1572962.
JD161673 - Sequence 142697 from Patent EP1572962.
JD444110 - Sequence 425134 from Patent EP1572962.
JD097307 - Sequence 78331 from Patent EP1572962.
JD551365 - Sequence 532389 from Patent EP1572962.
JD486546 - Sequence 467570 from Patent EP1572962.
JD355513 - Sequence 336537 from Patent EP1572962.
HQ447360 - Synthetic construct Homo sapiens clone IMAGE:100070681; CCSB001201_02 N-acetylneuraminic acid phosphatase (NANP) gene, encodes complete protein.
KJ895557 - Synthetic construct Homo sapiens clone ccsbBroadEn_04951 NANP gene, encodes complete protein.
EU831914 - Synthetic construct Homo sapiens clone HAIB:100066943; DKFZo008B0223 N-acetylneuraminic acid phosphatase protein (NANP) gene, encodes complete protein.
EU832008 - Synthetic construct Homo sapiens clone HAIB:100067037; DKFZo004B0224 N-acetylneuraminic acid phosphatase protein (NANP) gene, encodes complete protein.
AK074335 - Homo sapiens cDNA FLJ23755 fis, clone HEP17336.
JD140330 - Sequence 121354 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00520 - Amino sugar and nucleotide sugar metabolism
hsa01100 - Metabolic pathways

Reactome (by CSHL, EBI, and GO)

Protein Q8TBE9 (Reactome details) participates in the following event(s):

R-HSA-4084989 NANP dephosphorylates Neu5Ac-9-P to Neu5Ac
R-HSA-4085001 Sialic acid metabolism
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B3KP12, C20orf147, HDHD4, NANP_HUMAN, NM_152667, NP_689880, Q5JYN8, Q8TBE9, Q8TE97, Q9Y3N0
UCSC ID: uc002wuy.3
RefSeq Accession: NM_152667
Protein: Q8TBE9 (aka NANP_HUMAN)
CCDS: CCDS13173.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_152667.2
exon count: 2CDS single in 3' UTR: no RNA size: 3806
ORF size: 747CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1669.00frame shift in genome: no % Coverage: 99.82
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.