Human Gene LRRC29 (uc002esf.3) Description and Page Index
Description: Homo sapiens leucine rich repeat containing 29 (LRRC29), transcript variant 2, mRNA. RefSeq Summary (NM_001004055): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 9 tandem leucine-rich repeats. Two transcript variants encoding the same protein have been found for this gene. Other variants may occur, but their full-length natures have not been characterized. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr16:67,241,042-67,260,901 Size: 19,860 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr16:67,241,508-67,244,091 Size: 2,584 Coding Exon Count: 4
ID:LRC29_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 29; AltName: Full=F-box and leucine-rich repeat protein 9; AltName: Full=F-box protein FBL9; AltName: Full=F-box/LRR-repeat protein 9; FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). TISSUE SPECIFICITY: Expressed in heart, kidney, liver, lung and pancreas. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 7 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=AAF03701.1; Type=Frameshift; Positions=13;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LRRC29 CDC HuGE Published Literature: LRRC29 Positive Disease Associations: Lipoproteins, HDL Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on Q8WV35
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.