Human Gene GPR180 (uc001vly.3) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 180 (GPR180), mRNA.
RefSeq Summary (NM_180989): This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.224667.1, SRR1660805.140334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376958.5/ ENSP00000366157.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr13:95,254,104-95,286,899 Size: 32,796 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr13:95,254,182-95,279,425 Size: 25,244 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr13:95,254,104-95,286,899)mRNA (may differ from genome)Protein (440 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Integral membrane protein GPR180; AltName: Full=Intimal thickness-related receptor; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  MalaCards Disease Associations
  MalaCards Gene Search: GPR180
Diseases sorted by gene-association score: la crosse encephalitis (9), locked-in syndrome (8), contagious pustular dermatitis (8), meningeal melanocytoma (7), fungal meningitis (6), central nervous system melanocytic neoplasm (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.93 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 94.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.5078-0.545 Picture PostScript Text
3' UTR -1944.387474-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019336 - Rhodopsin-like_GPCR_TM_domain

Pfam Domains:
PF06814 - Lung seven transmembrane receptor
PF10192 - Rhodopsin-like GPCR transmembrane domain

ModBase Predicted Comparative 3D Structure on Q86V85
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0019236 response to pheromone

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK289850 - Homo sapiens cDNA FLJ75183 complete cds, highly similar to Homo sapiens G protein-coupled receptor 180, mRNA.
BC033906 - Homo sapiens G protein-coupled receptor 180, mRNA (cDNA clone IMAGE:5262994).
BC052243 - Homo sapiens G protein-coupled receptor 180, mRNA (cDNA clone MGC:59885 IMAGE:6083073), complete cds.
AK126794 - Homo sapiens cDNA FLJ44844 fis, clone BRACE3050504.
KJ903926 - Synthetic construct Homo sapiens clone ccsbBroadEn_13320 GPR180 gene, encodes complete protein.
AL832739 - Homo sapiens mRNA; cDNA DKFZp686I0613 (from clone DKFZp686I0613).
JD377842 - Sequence 358866 from Patent EP1572962.
JD314985 - Sequence 296009 from Patent EP1572962.
JD553254 - Sequence 534278 from Patent EP1572962.
JD037579 - Sequence 18603 from Patent EP1572962.
AK024059 - Homo sapiens cDNA FLJ13997 fis, clone Y79AA1002220.
JD357363 - Sequence 338387 from Patent EP1572962.
JD350603 - Sequence 331627 from Patent EP1572962.
JD273759 - Sequence 254783 from Patent EP1572962.
JD361020 - Sequence 342044 from Patent EP1572962.
JD039837 - Sequence 20861 from Patent EP1572962.
JD507085 - Sequence 488109 from Patent EP1572962.
JD386373 - Sequence 367397 from Patent EP1572962.
JD303430 - Sequence 284454 from Patent EP1572962.
JD502716 - Sequence 483740 from Patent EP1572962.
JD288078 - Sequence 269102 from Patent EP1572962.
JD347885 - Sequence 328909 from Patent EP1572962.
JD428581 - Sequence 409605 from Patent EP1572962.
JD550785 - Sequence 531809 from Patent EP1572962.
JD093520 - Sequence 74544 from Patent EP1572962.
AL832853 - Homo sapiens mRNA; cDNA DKFZp667K0825 (from clone DKFZp667K0825).
JD467854 - Sequence 448878 from Patent EP1572962.
JD464844 - Sequence 445868 from Patent EP1572962.
JD151346 - Sequence 132370 from Patent EP1572962.
JD514695 - Sequence 495719 from Patent EP1572962.
JD095602 - Sequence 76626 from Patent EP1572962.
JD115148 - Sequence 96172 from Patent EP1572962.
JD150214 - Sequence 131238 from Patent EP1572962.
JD182335 - Sequence 163359 from Patent EP1572962.
JD146533 - Sequence 127557 from Patent EP1572962.
JD538817 - Sequence 519841 from Patent EP1572962.
JD296405 - Sequence 277429 from Patent EP1572962.
JD566114 - Sequence 547138 from Patent EP1572962.
JD147282 - Sequence 128306 from Patent EP1572962.
JD412938 - Sequence 393962 from Patent EP1572962.
JD439325 - Sequence 420349 from Patent EP1572962.
JD309696 - Sequence 290720 from Patent EP1572962.
JD313090 - Sequence 294114 from Patent EP1572962.
AF339784 - Homo sapiens clone IMAGE:1895098, mRNA sequence.
JD078272 - Sequence 59296 from Patent EP1572962.
JD359912 - Sequence 340936 from Patent EP1572962.
JD524514 - Sequence 505538 from Patent EP1572962.
JD298177 - Sequence 279201 from Patent EP1572962.
JD049230 - Sequence 30254 from Patent EP1572962.
JD314733 - Sequence 295757 from Patent EP1572962.
JD508114 - Sequence 489138 from Patent EP1572962.
JD047081 - Sequence 28105 from Patent EP1572962.
JD326626 - Sequence 307650 from Patent EP1572962.
JD150346 - Sequence 131370 from Patent EP1572962.
JD446128 - Sequence 427152 from Patent EP1572962.
JD090256 - Sequence 71280 from Patent EP1572962.
JD300925 - Sequence 281949 from Patent EP1572962.
JD268600 - Sequence 249624 from Patent EP1572962.
AL049452 - Homo sapiens mRNA; cDNA DKFZp586C1322 (from clone DKFZp586C1322).

-  Other Names for This Gene
  Alternate Gene Symbols: A8K1D5, GP180_HUMAN, ITR, NM_180989, NP_851320, Q86V85
UCSC ID: uc001vly.3
RefSeq Accession: NM_180989
Protein: Q86V85 (aka GP180_HUMAN)
CCDS: CCDS9472.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_180989.5
exon count: 9CDS single in 3' UTR: no RNA size: 8895
ORF size: 1323CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2846.00frame shift in genome: no % Coverage: 99.78
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.