Description: Homo sapiens chromobox homolog 5 (CBX5), transcript variant 2, mRNA. RefSeq Summary (NM_001127321): This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:54,624,731-54,653,370 Size: 28,640 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr12:54,635,539-54,651,434 Size: 15,896 Coding Exon Count: 4
ID:CBX5_HUMAN DESCRIPTION: RecName: Full=Chromobox protein homolog 5; AltName: Full=Antigen p25; AltName: Full=Heterochromatin protein 1 homolog alpha; Short=HP1 alpha; FUNCTION: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. SUBUNIT: Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts with HP1BP3 (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys- 9'. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1. INTERACTION: Q9H2P0:ADNP; NbExp=2; IntAct=EBI-78219, EBI-1764854; Q8IXJ9:ASXL1; NbExp=2; IntAct=EBI-78219, EBI-1646500; P59598:Asxl1 (xeno); NbExp=5; IntAct=EBI-78219, EBI-5743705; Q13111:CHAF1A; NbExp=3; IntAct=EBI-78219, EBI-1020839; Q9NQS7:INCENP; NbExp=6; IntAct=EBI-78219, EBI-307907; Q14739:LBR; NbExp=4; IntAct=EBI-78219, EBI-1055147; Q9UIS9:MBD1; NbExp=5; IntAct=EBI-78219, EBI-867196; Q7Z3K3:POGZ; NbExp=5; IntAct=EBI-78219, EBI-1389308; O43463:SUV39H1; NbExp=3; IntAct=EBI-78219, EBI-349968; Q13263:TRIM28; NbExp=7; IntAct=EBI-78219, EBI-78139; SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. PTM: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper- phosphorylated during mitosis. PTM: Ubiquitinated. SIMILARITY: Contains 2 chromo domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P45973
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0007596 blood coagulation GO:0016032 viral process GO:0045892 negative regulation of transcription, DNA-templated GO:0070317 negative regulation of G0 to G1 transition
US Server
