Human Gene PARP11 (uc001qml.2) Description and Page Index
  Description: Homo sapiens poly (ADP-ribose) polymerase family, member 11 (PARP11), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:3,918,027-3,982,608 Size: 64,582 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr12:3,921,289-3,982,395 Size: 61,107 Coding Exon Count: 8 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:3,918,027-3,982,608)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PARP11
CDC HuGE Published Literature: PARP11

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.55 RPKM in Testis
Total median expression: 80.35 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.70213-0.407 Picture PostScript Text
3' UTR -809.253262-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00644 - Poly(ADP-ribose) polymerase catalytic domain
PF02825 - WWE domain

SCOP Domains:
56399 - ADP-ribosylation

ModBase Predicted Comparative 3D Structure on Q9NR21-4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  BC031073 - Homo sapiens poly (ADP-ribose) polymerase family, member 11, mRNA (cDNA clone MGC:33714 IMAGE:5284275), complete cds.
KJ902935 - Synthetic construct Homo sapiens clone ccsbBroadEn_12329 PARP11 gene, encodes complete protein.
CR749294 - Homo sapiens mRNA; cDNA DKFZp779H0122 (from clone DKFZp779H0122).
BX647487 - Homo sapiens mRNA; cDNA DKFZp686C13128 (from clone DKFZp686C13128).
BX640960 - Homo sapiens mRNA; cDNA DKFZp686D19169 (from clone DKFZp686D19169).
AK299372 - Homo sapiens cDNA FLJ52860 complete cds, highly similar to Homo sapiens poly (ADP-ribose) polymerase family, member 11 (PARP11), mRNA.
BC017569 - Homo sapiens poly (ADP-ribose) polymerase family, member 11, mRNA (cDNA clone MGC:22721 IMAGE:4077842), complete cds.
AF263540 - Homo sapiens MIB006 (C12orf6) mRNA, complete cds.
AK314916 - Homo sapiens cDNA, FLJ95824.
CU676008 - Synthetic construct Homo sapiens gateway clone IMAGE:100017035 5' read PARP11 mRNA.
HQ448712 - Synthetic construct Homo sapiens clone IMAGE:100072156; CCSB007564_02 poly (ADP-ribose) polymerase family, member 11 (PARP11) gene, encodes complete protein.
KJ902934 - Synthetic construct Homo sapiens clone ccsbBroadEn_12328 PARP11 gene, encodes complete protein.
AB529076 - Synthetic construct DNA, clone: pF1KB4080, Homo sapiens PARP11 gene for poly (ADP-ribose) polymerase family, member 11, without stop codon, in Flexi system.
AK096373 - Homo sapiens cDNA FLJ39054 fis, clone NT2RP7012516.
JD506190 - Sequence 487214 from Patent EP1572962.
JD490318 - Sequence 471342 from Patent EP1572962.
JD045002 - Sequence 26026 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C12orf6, NM_020367, NP_065100, Q9NR21-4
UCSC ID: uc001qml.2
RefSeq Accession: NM_020367
Protein: Q9NR21-4, splice isoform of Q9NR21 CCDS: CCDS8523.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020367.4
exon count: 8CDS single in 3' UTR: no RNA size: 4492
ORF size: 1017CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2234.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.