Human Gene GPATCH2 (uc001hlf.1) Description and Page Index
  Description: Homo sapiens G patch domain containing 2 (GPATCH2), mRNA.
RefSeq Summary (NM_018040): The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
Transcript (Including UTRs)
   Position: hg19 chr1:217,603,834-217,804,409 Size: 200,576 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr1:217,604,487-217,804,313 Size: 199,827 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:217,603,834-217,804,409)mRNA (may differ from genome)Protein (528 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=G patch domain-containing protein 2;
SIMILARITY: Contains 1 G-patch domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GPATCH2
CDC HuGE Published Literature: GPATCH2
Positive Disease Associations: Heart Failure
Related Studies:
  1. Heart Failure
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.33 RPKM in Testis
Total median expression: 76.75 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.4096-0.285 Picture PostScript Text
3' UTR -137.80653-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000467 - G_patch_dom
IPR026291 - Gpatch2

Pfam Domains:
PF01585 - G-patch domain
PF12656 - G-patch domain

ModBase Predicted Comparative 3D Structure on Q9NW75
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Biological Process:
GO:0010923 negative regulation of phosphatase activity

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016607 nuclear speck

-  Descriptions from all associated GenBank mRNAs
  AK001114 - Homo sapiens cDNA FLJ10252 fis, clone HEMBB1000807.
AK024701 - Homo sapiens cDNA: FLJ21048 fis, clone CAS00319.
JD225858 - Sequence 206882 from Patent EP1572962.
JD438040 - Sequence 419064 from Patent EP1572962.
JD532993 - Sequence 514017 from Patent EP1572962.
JD086098 - Sequence 67122 from Patent EP1572962.
JD410182 - Sequence 391206 from Patent EP1572962.
JD363361 - Sequence 344385 from Patent EP1572962.
JD288335 - Sequence 269359 from Patent EP1572962.
JD255089 - Sequence 236113 from Patent EP1572962.
AK310304 - Homo sapiens cDNA, FLJ17346.
BC042193 - Homo sapiens G patch domain containing 2, mRNA (cDNA clone MGC:47636 IMAGE:5532608), complete cds.
BC063474 - Homo sapiens G patch domain containing 2, mRNA (cDNA clone MGC:74998 IMAGE:5206348), complete cds.
AK291238 - Homo sapiens cDNA FLJ77283 complete cds, highly similar to Homo sapiens G patch domain containing 2, mRNA.
KJ902763 - Synthetic construct Homo sapiens clone ccsbBroadEn_12157 GPATCH2 gene, encodes complete protein.
AB527654 - Synthetic construct DNA, clone: pF1KB9140, Homo sapiens GPATCH2 gene for G patch domain containing 2, without stop codon, in Flexi system.
CU687736 - Synthetic construct Homo sapiens gateway clone IMAGE:100021724 5' read GPATC2 mRNA.
BC027719 - Homo sapiens G patch domain containing 2, mRNA (cDNA clone IMAGE:4589911), partial cds.
JD549645 - Sequence 530669 from Patent EP1572962.
JD559933 - Sequence 540957 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: GPATC2, GPTC2_HUMAN, NM_018040, NP_060510, Q5VYK7, Q5VYK8, Q86YE7, Q9NW75
UCSC ID: uc001hlf.1
RefSeq Accession: NM_018040
Protein: Q9NW75 (aka GPTC2_HUMAN or GPT2_HUMAN)
CCDS: CCDS1518.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_018040.2
exon count: 10CDS single in 3' UTR: no RNA size: 2336
ORF size: 1587CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3122.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.