Human Gene ZNF501 (uc003cnu.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 501 (ZNF501), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:44,771,098-44,778,575 Size: 7,478 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:44,775,914-44,776,729 Size: 816 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:44,771,098-44,778,575)mRNA (may differ from genome)Protein (271 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 501; AltName: Full=Zinc finger protein 52;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF501
Diseases sorted by gene-association score: split hand-foot malformation 1 (2)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.06 RPKM in Testis
Total median expression: 50.43 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -161.60427-0.378 Picture PostScript Text
3' UTR -517.941846-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q96CX3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK316574 - Homo sapiens cDNA, FLJ93986, highly similar to Homo sapiens zinc finger protein 501 (ZNF501), mRNA.
AK054613 - Homo sapiens cDNA FLJ30051 fis, clone ADRGL1000065, moderately similar to ZINC FINGER PROTEIN 135.
AK297216 - Homo sapiens cDNA FLJ56990 complete cds, highly similar to Zinc finger protein 501.
BC013762 - Homo sapiens zinc finger protein 501, mRNA (cDNA clone MGC:21738 IMAGE:4521303), complete cds.
JD112815 - Sequence 93839 from Patent EP1572962.
JD246042 - Sequence 227066 from Patent EP1572962.
JD261755 - Sequence 242779 from Patent EP1572962.
JD207027 - Sequence 188051 from Patent EP1572962.
AB464764 - Synthetic construct DNA, clone: pF1KB8781, Homo sapiens ZNF501 gene for zinc finger protein 501, without stop codon, in Flexi system.
CU680674 - Synthetic construct Homo sapiens gateway clone IMAGE:100018661 5' read ZNF501 mRNA.
KJ903656 - Synthetic construct Homo sapiens clone ccsbBroadEn_13050 ZNF501 gene, encodes complete protein.
JD314871 - Sequence 295895 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD146046 - Sequence 127070 from Patent EP1572962.
JD043330 - Sequence 24354 from Patent EP1572962.
JD300544 - Sequence 281568 from Patent EP1572962.
JD498174 - Sequence 479198 from Patent EP1572962.
JD046744 - Sequence 27768 from Patent EP1572962.
JD449157 - Sequence 430181 from Patent EP1572962.
JD379906 - Sequence 360930 from Patent EP1572962.
JD344557 - Sequence 325581 from Patent EP1572962.
JD177743 - Sequence 158767 from Patent EP1572962.
JD339579 - Sequence 320603 from Patent EP1572962.
JD482317 - Sequence 463341 from Patent EP1572962.
JD449523 - Sequence 430547 from Patent EP1572962.
JD199812 - Sequence 180836 from Patent EP1572962.
JD478685 - Sequence 459709 from Patent EP1572962.
JD302074 - Sequence 283098 from Patent EP1572962.
JD062361 - Sequence 43385 from Patent EP1572962.
JD183248 - Sequence 164272 from Patent EP1572962.
JD344286 - Sequence 325310 from Patent EP1572962.
JD312161 - Sequence 293185 from Patent EP1572962.
JD346643 - Sequence 327667 from Patent EP1572962.
JD346644 - Sequence 327668 from Patent EP1572962.
JD488555 - Sequence 469579 from Patent EP1572962.
JD494768 - Sequence 475792 from Patent EP1572962.
JD282907 - Sequence 263931 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DLY7, NM_145044, NP_659481, Q96CX3, Q96NU9, uc003cnu.1, ZN501_HUMAN, ZNF52
UCSC ID: uc003cnu.2
RefSeq Accession: NM_145044
Protein: Q96CX3 (aka ZN501_HUMAN or Z501_HUMAN)
CCDS: CCDS2720.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_145044.3
exon count: 3CDS single in 3' UTR: no RNA size: 3107
ORF size: 816CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1615.50frame shift in genome: no % Coverage: 99.42
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.