Human Gene ZNF283 (uc002oxr.4) Description and Page Index
  Description: Homo sapiens zinc finger protein 283 (ZNF283), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:44,331,473-44,353,050 Size: 21,578 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr19:44,337,657-44,352,793 Size: 15,137 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:44,331,473-44,353,050)mRNA (may differ from genome)Protein (679 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 283; AltName: Full=Zinc finger protein HZF19;
FUNCTION: May be involved in transcriptional regulation.
TISSUE SPECIFICITY: Detected in prostate, testis, and pancreas.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 15 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence lacks 6 bp for unexplained reasons;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.90 RPKM in Brain - Cerebellum
Total median expression: 43.99 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.90268-0.328 Picture PostScript Text
3' UTR -46.22257-0.180 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q8N7M2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK294852 - Homo sapiens cDNA FLJ59323 complete cds, highly similar to Zinc finger protein 283.
AK098175 - Homo sapiens cDNA FLJ40856 fis, clone TRACH2016498, moderately similar to ZINC FINGER PROTEIN 184.
JD300040 - Sequence 281064 from Patent EP1572962.
JD046110 - Sequence 27134 from Patent EP1572962.
BC045755 - Homo sapiens zinc finger protein 283, mRNA (cDNA clone IMAGE:4798568), complete cds.
JD339436 - Sequence 320460 from Patent EP1572962.
BC167809 - Synthetic construct Homo sapiens clone IMAGE:100068199, MGC:195816 zinc finger protein 283 (ZNF283) mRNA, encodes complete protein.
AY166784 - Homo sapiens zinc finger protein LOC163140 mRNA, partial cds.
JD245531 - Sequence 226555 from Patent EP1572962.
AY500359 - Homo sapiens zinc finger protein 19 (HZF19) mRNA, partial cds.
AY500364 - Homo sapiens zinc finger protein 41 (HZF41) mRNA, partial cds.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
JD032199 - Sequence 13223 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DGZ5, B7WP04, NM_181845, NP_862828, Q6RFR9, Q86WM6, Q8N7M2, ZN283_HUMAN
UCSC ID: uc002oxr.4
RefSeq Accession: NM_181845
Protein: Q8N7M2 (aka ZN283_HUMAN or Z283_HUMAN)
CCDS: CCDS46097.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_181845.1
exon count: 7CDS single in 3' UTR: no RNA size: 2565
ORF size: 2040CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3997.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.