Human Gene ZFP30 (uc002ogx.1) Description and Page Index
  Description: Homo sapiens ZFP30 zinc finger protein (ZFP30), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:38,123,389-38,146,313 Size: 22,925 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr19:38,125,882-38,138,723 Size: 12,842 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:38,123,389-38,146,313)mRNA (may differ from genome)Protein (519 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZFP30_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 30 homolog; Short=Zfp-30; AltName: Full=Zinc finger protein 745;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAA76805.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZFP30
CDC HuGE Published Literature: ZFP30

-  MalaCards Disease Associations
  MalaCards Gene Search: ZFP30
Diseases sorted by gene-association score: cerebral visual impairment (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.07 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 63.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -237.40558-0.425 Picture PostScript Text
3' UTR -884.792493-0.355 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9Y2G7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC041087 - Homo sapiens zinc finger protein 30 homolog (mouse), mRNA (cDNA clone MGC:45116 IMAGE:5579247), complete cds.
BC050542 - Homo sapiens zinc finger protein 30 homolog (mouse), mRNA (cDNA clone IMAGE:6052284).
AB023178 - Homo sapiens KIAA0961 mRNA for KIAA0961 protein.
LF384241 - JP 2014500723-A/191744: Polycomb-Associated Non-Coding RNAs.
GU388430 - Homo sapiens zinc finger protein 30 (ZFP30) mRNA, complete cds.
AK297301 - Homo sapiens cDNA FLJ60691 complete cds, moderately similar to Zinc finger protein 30.
MA619818 - JP 2018138019-A/191744: Polycomb-Associated Non-Coding RNAs.
JD312578 - Sequence 293602 from Patent EP1572962.
JD531975 - Sequence 512999 from Patent EP1572962.
JD364123 - Sequence 345147 from Patent EP1572962.
JD248174 - Sequence 229198 from Patent EP1572962.
JD120050 - Sequence 101074 from Patent EP1572962.
JD180965 - Sequence 161989 from Patent EP1572962.
JD196433 - Sequence 177457 from Patent EP1572962.
JD523083 - Sequence 504107 from Patent EP1572962.
JD166976 - Sequence 148000 from Patent EP1572962.
JD154446 - Sequence 135470 from Patent EP1572962.
JD198843 - Sequence 179867 from Patent EP1572962.
JD388957 - Sequence 369981 from Patent EP1572962.
JD293448 - Sequence 274472 from Patent EP1572962.
JD457527 - Sequence 438551 from Patent EP1572962.
JD457528 - Sequence 438552 from Patent EP1572962.
JD227648 - Sequence 208672 from Patent EP1572962.
JD523082 - Sequence 504106 from Patent EP1572962.
JD457526 - Sequence 438550 from Patent EP1572962.
JD405628 - Sequence 386652 from Patent EP1572962.
JD547670 - Sequence 528694 from Patent EP1572962.
JD547669 - Sequence 528693 from Patent EP1572962.
JD106632 - Sequence 87656 from Patent EP1572962.
JD047678 - Sequence 28702 from Patent EP1572962.
JD135838 - Sequence 116862 from Patent EP1572962.
JD354436 - Sequence 335460 from Patent EP1572962.
JD439278 - Sequence 420302 from Patent EP1572962.
JD112142 - Sequence 93166 from Patent EP1572962.
JD420280 - Sequence 401304 from Patent EP1572962.
JD112141 - Sequence 93165 from Patent EP1572962.
JD383844 - Sequence 364868 from Patent EP1572962.
JD420279 - Sequence 401303 from Patent EP1572962.
JD558269 - Sequence 539293 from Patent EP1572962.
JD564336 - Sequence 545360 from Patent EP1572962.
JD070835 - Sequence 51859 from Patent EP1572962.
JD319335 - Sequence 300359 from Patent EP1572962.
JD319334 - Sequence 300358 from Patent EP1572962.
JD179843 - Sequence 160867 from Patent EP1572962.
JD067978 - Sequence 49002 from Patent EP1572962.
JD481483 - Sequence 462507 from Patent EP1572962.
JD284146 - Sequence 265170 from Patent EP1572962.
JD433715 - Sequence 414739 from Patent EP1572962.
JD232304 - Sequence 213328 from Patent EP1572962.
JD504379 - Sequence 485403 from Patent EP1572962.
JD081687 - Sequence 62711 from Patent EP1572962.
JD501157 - Sequence 482181 from Patent EP1572962.
JD226016 - Sequence 207040 from Patent EP1572962.
JD566787 - Sequence 547811 from Patent EP1572962.
JD349225 - Sequence 330249 from Patent EP1572962.
AB384061 - Synthetic construct DNA, clone: pF1KSDA0961, Homo sapiens ZFP30 gene for zinc finger protein 30 homolog, complete cds, without stop codon, in Flexi system.
EU446777 - Synthetic construct Homo sapiens clone IMAGE:100069934; IMAGE:100011986; FLH257141.01L zinc finger protein 30 homolog (mouse) (ZFP30) gene, encodes complete protein.
JD032199 - Sequence 13223 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
JD246154 - Sequence 227178 from Patent EP1572962.
LF367307 - JP 2014500723-A/174810: Polycomb-Associated Non-Coding RNAs.
JD470608 - Sequence 451632 from Patent EP1572962.
JD223616 - Sequence 204640 from Patent EP1572962.
MA602884 - JP 2018138019-A/174810: Polycomb-Associated Non-Coding RNAs.
JD336239 - Sequence 317263 from Patent EP1572962.
JD537098 - Sequence 518122 from Patent EP1572962.
JD310417 - Sequence 291441 from Patent EP1572962.
JD220948 - Sequence 201972 from Patent EP1572962.
JD043869 - Sequence 24893 from Patent EP1572962.
JD459228 - Sequence 440252 from Patent EP1572962.
JD283251 - Sequence 264275 from Patent EP1572962.
JD156169 - Sequence 137193 from Patent EP1572962.
JD303905 - Sequence 284929 from Patent EP1572962.
JD045996 - Sequence 27020 from Patent EP1572962.
JD455663 - Sequence 436687 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2G7 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0961, NM_014898, NP_055713, Q58EY8, Q9Y2G7, ZFP30_HUMAN, ZNF745
UCSC ID: uc002ogx.1
RefSeq Accession: NM_014898
Protein: Q9Y2G7 (aka ZFP30_HUMAN)
CCDS: CCDS33005.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014898.2
exon count: 6CDS single in 3' UTR: no RNA size: 4611
ORF size: 1560CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3309.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.