Human Gene CDC37 (uc002mof.1) Description and Page Index
Description: Homo sapiens cell division cycle 37 (CDC37), mRNA. RefSeq Summary (NM_007065): The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1159146.1, SRR3476690.452014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222005.7/ ENSP00000222005.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr19:10,501,809-10,514,271 Size: 12,463 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr19:10,502,227-10,514,155 Size: 11,929 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16543
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006457 protein folding GO:0006605 protein targeting GO:0010608 posttranscriptional regulation of gene expression GO:0018108 peptidyl-tyrosine phosphorylation GO:0038128 ERBB2 signaling pathway GO:0045859 regulation of protein kinase activity GO:0050821 protein stabilization GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0098779 mitophagy in response to mitochondrial depolarization
R-HSA-1218833 Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 R-HSA-1247999 EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. R-HSA-1963589 ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 R-HSA-1918092 CHIP (STUB1) mediates ubiquitination of ERBB2 R-HSA-1918095 CUL5 mediates ubiquitination of ERBB2 R-HSA-1248002 Ligand-independent dimerization of EGFRvIII mutant R-HSA-1220613 EGF-induced dimerization of ligand-responsive EGFR mutants R-HSA-1220612 Binding of EGF to ligand-responsive EGFR mutants R-HSA-1220614 Spontaneous dimerization of ligand-responsive EGFR mutants R-HSA-1248655 Trans-autophosphorylation of EGFRvIII mutant dimers R-HSA-5637764 Binding of GRB2:GAB1:PIK3R1 complex to p-EGFRvIII mutant R-HSA-5637766 Binding of SHC1 to p-5Y-EGFRvIII R-HSA-5637770 Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII R-HSA-5637792 PLC-gamma 1 binds to p-EGFRvIII mutant R-HSA-5637800 Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant R-HSA-1220611 Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors R-HSA-1220610 Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants R-HSA-5637765 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFRvIII R-HSA-5637795 Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant R-HSA-5637796 Phosphorylation of SHC1 by p-5Y-EGFRvIII R-HSA-5637798 Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex R-HSA-1169421 Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers R-HSA-5637806 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) R-HSA-1225947 Binding of SHC1 to p-6Y-EGFR mutants R-HSA-1225949 Binding of CBL to ligand-responsive p-6Y-EGFR mutants R-HSA-1225950 Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants R-HSA-1226016 Binding of GRB2:GAB1:PIK3R1 complex to ligand-responsive p-6Y-EGFR mutants R-HSA-1247841 PLCG1 binds to ligand-responsive p-6Y-EGFR mutants R-HSA-1247842 Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants R-HSA-5637801 Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) R-HSA-1225961 Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex R-HSA-1225952 Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants R-HSA-1225960 Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants R-HSA-1226012 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and ligand-responsive p-6Y-EGFR mutants R-HSA-1247844 Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants R-HSA-1225951 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) R-HSA-1226014 Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-1227986 Signaling by ERBB2 R-HSA-8863795 Downregulation of ERBB2 signaling R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637812 Signaling by EGFRvIII in Cancer R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-1643713 Signaling by EGFR in Cancer R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease