Human Gene MLLT10 (uc021pny.1) Description and Page Index
  Description: Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (MLLT10), transcript variant 3, mRNA.
RefSeq Summary (NM_001195626): This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
Transcript (Including UTRs)
   Position: hg19 chr10:21,823,574-22,032,559 Size: 208,986 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg19 chr10:21,823,574-22,030,912 Size: 207,339 Coding Exon Count: 22 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:21,823,574-22,032,559)mRNA (may differ from genome)Protein (1068 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MLLT10
CDC HuGE Published Literature: MLLT10
Positive Disease Associations: Meningioma
Related Studies:
  1. Meningioma
    Sara E Dobbins et al. Nature genetics 2011, Common variation at 10p12.31 near MLLT10 influences meningioma risk., Nature genetics. [PubMed 21804547]

-  MalaCards Disease Associations
  MalaCards Gene Search: MLLT10
Diseases sorted by gene-association score: leukemia, acute myeloid* (116), precursor t-cell acute lymphoblastic leukemia* (101), acute monocytic leukemia (16), acute biphenotypic leukemia (13), myeloid/lymphoid or mixed lineage leukemia (12), neonatal leukemia (7), hematologic cancer (6), b-cell adult acute lymphocytic leukemia (6), acute leukemia (5), leukemia, acute lymphoblastic (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.70 RPKM in Testis
Total median expression: 382.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -425.861647-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019786 - Zinc_finger_PHD-type_CS
IPR011011 - Znf_FYVE_PHD
IPR001965 - Znf_PHD
IPR019787 - Znf_PHD-finger
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00628 - PHD-finger
PF13771 - PHD-like zinc-binding domain
PF13831 - PHD-finger
PF13832 - PHD-zinc-finger like domain

SCOP Domains:
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q5VX90
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Descriptions from all associated GenBank mRNAs
  U13948 - Human zinc finger/leucine zipper protein (AF10) mRNA, complete cds.
AB209755 - Homo sapiens mRNA for myeloid/lymphoid or mixed-lineage leukemia translocated to, 10 isoform a variant protein.
BC129946 - Homo sapiens cDNA clone IMAGE:40124317.
BC156206 - Synthetic construct Homo sapiens clone IMAGE:100061540, MGC:190017 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (MLLT10) mRNA, encodes complete protein.
BC156949 - Synthetic construct Homo sapiens clone IMAGE:100063630, MGC:190815 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (MLLT10) mRNA, encodes complete protein.
AY598745 - Homo sapiens AF10 (AF10) mRNA, complete cds.
LF383675 - JP 2014500723-A/191178: Polycomb-Associated Non-Coding RNAs.
BX648210 - Homo sapiens mRNA; cDNA DKFZp779J0967 (from clone DKFZp779J0967).
BX640774 - Homo sapiens mRNA; cDNA DKFZp686E10210 (from clone DKFZp686E10210).
MA619252 - JP 2018138019-A/191178: Polycomb-Associated Non-Coding RNAs.
AY187923 - Homo sapiens MLL/AF10 fusion protein UPN9610I (MLL/AF10 fusion) mRNA, partial cds.
BC032532 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, mRNA (cDNA clone IMAGE:5526778), with apparent retained intron.
BC065376 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, mRNA (cDNA clone IMAGE:6671384).
BC080577 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, mRNA (cDNA clone IMAGE:6597328), complete cds.
BC052798 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, mRNA (cDNA clone IMAGE:5808940), with apparent retained intron.
BC094844 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, mRNA (cDNA clone IMAGE:6574007), with apparent retained intron.
CU687346 - Synthetic construct Homo sapiens gateway clone IMAGE:100023068 5' read MLLT10 mRNA.
KJ892460 - Synthetic construct Homo sapiens clone ccsbBroadEn_01854 MLLT10 gene, encodes complete protein.
AF060927 - Homo sapiens type I AF10/CALM fusion protein (AF10/CALM) mRNA, partial cds.
AF060929 - Homo sapiens type III AF10/CALM fusion protein (AF10/CALM) mRNA, partial cds.
AF060934 - Homo sapiens type I AF10 protein (AF10) mRNA, partial cds.
AF060935 - Homo sapiens type II AF10 protein (AF10) mRNA, partial cds.
AF060936 - Homo sapiens type III AF10 protein (AF10) mRNA, partial cds.
AF060937 - Homo sapiens type IV AF10 protein (AF10) mRNA, partial cds.
AF060938 - Homo sapiens type V AF10 protein (AF10) mRNA, partial cds.
AF060932 - Homo sapiens type II CALM/AF10 fusion protein (CALM/AF10) mRNA, partial cds.
AF272383 - Homo sapiens clone 1568-1 MLL/AF-10 fusion protein mRNA, partial cds.
AF272385 - Homo sapiens clone 1552r2 MLL/AF-10 fusion protein mRNA, partial cds.
AF272376 - Homo sapiens clone 1370-50 aberrant MLL/AF-10 fusion protein transcript, partial sequence.
KF778381 - Homo sapiens MLL-MLLT10 fusion protein mRNA, partial cds.
AK301213 - Homo sapiens cDNA FLJ61176 complete cds, highly similar to Protein AF-10.
AK310803 - Homo sapiens cDNA, FLJ17845.
AK128264 - Homo sapiens cDNA FLJ46400 fis, clone THYMU3005050, weakly similar to AF-10 protein.
JD049486 - Sequence 30510 from Patent EP1572962.
JD360040 - Sequence 341064 from Patent EP1572962.
JD073614 - Sequence 54638 from Patent EP1572962.
JD358699 - Sequence 339723 from Patent EP1572962.
AL137295 - Homo sapiens mRNA; cDNA DKFZp434M2216 (from clone DKFZp434M2216).

-  Other Names for This Gene
  Alternate Gene Symbols: AF10, NM_001195626, NP_001182555, Q5VX90, Q5VX90_HUMAN, RP11-399C16.2-002
UCSC ID: uc021pny.1
RefSeq Accession: NM_001195626
Protein: Q5VX90 CCDS: CCDS55708.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001195626.1
exon count: 22CDS single in 3' UTR: no RNA size: 4864
ORF size: 3207CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6477.00frame shift in genome: no % Coverage: 99.79
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.